Protein Alignment par-1 and MAP3K2

DIOPT Version :9

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: NP_001358839.1
• Gene: MAP3K2 / 10746
• HGNCID: 6854
• Length: 619
• Species: Homo sapiens
• Alignment Length: 495
• Identity: 119/495 - (24%)
• Similarity: 194/495 - (39%)
• Gaps: 112/495 - (22%)

  Fly     7 TTLQSVPEALPADSVSNGTASNVAAPAAPVSSATNAVPPLAAVSSTTATYATNSISTSSHSVKDQ 71
            |.|:.:|.....|:...|............:|...:.||...:.......|.|...||.:|..:.
Human   128 TNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEF 192

  Fly    72 QQQQQQQQHDSANANIVSLPPTTTPVANTNTMMPIVTSSNSATSNSTAATPTPASGAAATGGVGS 136
            ..:...|..|              |::        ::|..::.|.|..:..:|..|.:.
Human   193 IPESMDQMLD--------------PLS--------LSSPENSGSGSCPSLDSPLDGESY------ 229

  Fly   137 VSQGPATVSASAANTNHSHQ---------------------HSHQHHHHVANNMTTDG------A 174
                |.:....|.:...:||                     ..|..:||...|   ||      |
Human   230 ----PKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYN---DGRKTFPRA 287

  Fly   175 RLSSNNS--AVVASSAINHHHHHTPGSGV-APTVNKNVLSTHSA---HPSAIKQRTSSAKGSPNM 233
            |.:...|  :.|:.|..:|....:.||.: .|..:.:.:....:   :|:......|....||.
Human   288 RRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPR- 351

  Fly   234 QMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGS----- 293
                 ||..||          |.|.:|:|.|.:|.|...:.||:|:|:|   :.|.:|.|
Human   352 -----APTNWR----------LGKLLGQGAFGRVYLCYDVDTGRELAVK---QVQFDPDSPETSK 398

  Fly   294 -LQKLFREVRIMKMLDHPNIVKLFQVIE--TEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVK 355
             :..|..|::::|.|.|..||:.:..:.  .||||.:.|||..||.:.|.|..:|.:.|...|..
Human   399 EVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKY 463

  Fly   356 FRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFC---------- 410
            .|||:..|.|.|...|:|||:|..|:|.||..|:|:.|||.|      .:|.|.|
Human   464 TRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGAS------KRLQTICLSGTGMKSVT 522

  Fly   411 GSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 450
            |:|.:.:||:..|:.| |.:.|:||:...:..:::...|:
Human   523 GTPYWMSPEVISGEGY-GRKADIWSVACTVVEMLTEKPPW 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	71/217 (33%)
		S_TKc	253..504	CDD:214567	71/216 (33%)
		UBA_MARK_Par1	525..563	CDD:270522
		MARK1-3_C	839..936	CDD:213381
MAP3K2	NP_001358839.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..45
		PB1_Mekk2_3	44..122	CDD:99726
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..173		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..248		11/78 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	289..355		13/71 (18%)
		STKc_MEKK2	353..616	CDD:270818	74/229 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000