Protein Alignment par-1 and SIK1B

DIOPT Version :9

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: NP_001307572.1
• Gene: SIK1B / 102724428
• -ID: -
• Length: 783
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 208/564 - (36%)
• Similarity: 309/564 - (54%)
• Gaps: 84/564 - (14%)

  Fly   209 VLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHL 273
            ::|..||.|:          |....|.:   |:|       :|.|.:.:|:||||||.||||:|.
Human     3 IMSEFSADPA----------GQGQGQQK---PLR-------VGFYDIERTLGKGNFAVVKLARHR 47

  Fly   274 PTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVF 338
            .|..:|||||||||:|:..:|:|::|||::||:|:||:|:||:||:||:..||::.|:|..||:|
Human    48 VTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMF 112

  Fly   339 DYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPG 403
            |||..:|.:.|.|||.||.||:|||:|||...|:|||||.||||||..::||:|||||.|.:..|
Human   113 DYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSG 177

  Fly   404 SKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYR 468
            ..|.|:||||||||||:|:||:|:||::|:|||||:||.||.|||||||..|..||:|||.|::|
Human   178 EPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFR 242

  Fly   469 IPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLA--------- 524
            |||:||.|||:|:|:.||::||:|.::..|...:||       ..:|.:...|..|
Human   243 IPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWM-------RAEPCLPGPACPAFSAHSYTSN 300

  Fly   525 ----DPKRIEALVAMGYNRSEIEASLSQVRYDDVFAT-YLLLGRKSTDPESDGSRSGSSLSLRNI 584
                |.:.:..:..:|.:|.....||....|:...|. ||||.|......:..:|.|.:...|..
Human   301 LGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPR 365

  Fly   585 SGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAATV--------------- 634
            |.:.:|.......:               ||.|.|.|.....|.....:|
Human   366 SSDLSGLEVPQEGL---------------STDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQW 415

  Fly   635 -------AAATGAV--GAVNPSNNYNAAGSAADRASVGSNFKR--QNTIDSATIKENTARLAAQN 688
                   |:.:|..  ..|:||:..:.|.|...|...|...::  |.::.|:|.:.:|  ||..:
Human   416 PLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHT--LAEVS 478

  Fly   689 QRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSG 732
            .|.:..|...:..:.:|..|||:..::......:.:::.:|.||
Human   479 TRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSG 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	146/251 (58%)
		S_TKc	253..504	CDD:214567	146/250 (58%)
		UBA_MARK_Par1	525..563	CDD:270522	11/38 (29%)
		MARK1-3_C	839..936	CDD:213381
SIK1B	NP_001307572.1	STKc_SIK	26..278	CDD:270973	146/251 (58%)
		UBA_SIK1	300..349	CDD:270591	12/48 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..377		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..477		8/29 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810