DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and LOC100911229

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_038951080.1	Gene:	LOC100911229 / 100911229	RGDID:	6494469	Length:	654	Species:	Rattus norvegicus

Alignment Length:	672	Identity:	191/672 - (28%)
Similarity:	306/672 - (45%)	Gaps:	135/672 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 SAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVR 302
            |:|.:..|..:|   |:::.::|:|.|.:||||.||.|..:||||::.|:..|    ..|..|:.
  Rat    12 SSPFQEDALTDH---YRILASLGQGGFGEVKLASHLLTQTKVAIKVLPKSNKN----LLLKSEIE 69

  Fly   303 IMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCH 367
            |||.||||:|:||..:|:|.:.:::::|:|.|||:...:...|.:.|:|....|||:|.|:||||
  Rat    70 IMKSLDHPHIIKLLHIIDTNENIFIVLEHAVGGELLTRIEDFGYLPEEECNRLFRQMVLALQYCH 134

  Fly   368 QKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVD 432
            |:.|||||:|.||:|||.:.|:|::|||.|.:...|.||.|.||:.||.|||||....|||..:|
  Rat   135 QRGIIHRDIKPENILLDHKGNVKLSDFGLSTKIVMGQKLTTLCGTLPYCAPELFNLNGYDGQAID 199

  Fly   433 VWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLET 497
            ||||||:||.:.:|.|||.|.|.:.:::::|.|:|.:.|.:|.|..:::.|.|.:||.:|..:..
  Rat   200 VWSLGVVLYYMATGCLPFQGFTYQAIKQKILSGRYSVNFRLSPDLWDVIAKLLTVNPRERPRVHE 264

  Fly   498 IMGDKWMNMGFEEDELKPYIEPKADLA-------DPKRIEALVAMGYNRSEIEASLSQVRYDDVF 555
            |:...|:.   .|:|:.|     :.|.       ||..:..:..|||.:.:|..||.:.::|.|.
  Rat   265 ILRFNWLK---NENEVSP-----SSLGGNTDSHPDPTILVMMGDMGYEQGQIRESLRERKFDQVM 321

  Fly   556 ATYLLLGRKSTDPE----------------SDGS--------RSGSSL----------------- 579
            ||||:|..|:...:                |.||        |.||||
  Rat   322 ATYLMLREKACSEDKSIKTPHPTQCAQTLKSTGSTTEKQTTLRRGSSLPTLTTFYLPSKLESLNK 386

  Fly   580 ----SLR-------NISGNDAGANAGSASVQSPT--------------HRG----VHRSISASST 615
                ::|       |........|.|..::.|.|              ::|    |..::....|
  Rat   387 EKRTTMRHTMPPNLNCFNKSESLNKGRRTIVSHTISPTLNCFNKPESLNKGKRTIVRHTMPPKKT 451

  Fly   616 KPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTIDSATIKEN 680
            .|.||....:..:....:.:..:....:.:||....::.|.......||.:.::.......:..:
  Rat   452 SPVRRICPRLHKSFGMGSASEDSSKRNSSDPSLTIFSSQSFMSAFKYGSTYSKRKAFLQCILHYH 516

  Fly   681 TARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKT 745
            .::...|.:.....:.|        ||:...|.:..:..||.....|. |:|.:..|:  |.||:
  Rat   517 ASQEEDQYKTTIIPSGK--------LNTTVPPNSLQEDQPTGHLHNVL-TAGAVDNRN--LQEKS 570

  Fly   746 ---SSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGA 807
               |:|......||       ::...::.||...||.          |.|.|:.|
  Rat   571 PPFSTTATKGEGPA-------IKERESIPSSPRAPRE----------QFRGRSQT---------- 608

  Fly   808 SGDSSHPGRMSFFSKLSSRFSK 829
              ....|.|...:..|.|.|.|
  Rat   609 --PPRAPFRRRVWKTLKSGFLK 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	109/251 (43%)
		S_TKc	253..504	CDD:214567	109/250 (44%)
		UBA_MARK_Par1	525..563	CDD:270522	15/37 (41%)
		MARK1-3_C	839..936	CDD:213381
LOC100911229	XP_038951080.1	STKc_AMPK-like	23..270	CDD:270905	110/253 (43%)
LOC100911229	XP_038951080.1	UBA_MARK_Par1	290..329	CDD:270522	15/38 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910