DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and sik3

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_004916140.2	Gene:	sik3 / 100492939	XenbaseID:	XB-GENE-6042192	Length:	1284	Species:	Xenopus tropicalis

Alignment Length:	985	Identity:	318/985 - (32%)
Similarity:	466/985 - (47%)	Gaps:	170/985 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 SSAKGSPNMQM--RSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKT 287
            ::..|.|..|:  ..:||.|       ||.|::.:||||||||.||||.|:.|..:|||||||||
Frog     3 ATVPGGPGTQLPPHRAAPAR-------IGYYEIDRTIGKGNFAVVKLATHIVTRAKVAIKIIDKT 60

  Fly   288 QLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEA 352
            :|:..:|:|:||||:|||||.||:|::|:||:|||:.:||:.|||||||:||:||.||||.||||
Frog    61 KLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEA 125

  Fly   353 RVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAA 417
            |.||:|||:||.:||.:.|:||||||||||||:.||||||||||||.||||..|.|:||||||||
Frog   126 RKKFKQIVAAVHFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNRFTPGQLLKTWCGSPPYAA 190

  Fly   418 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLR 482
            ||||:||:||||:||:|||||:||.||.|:||||||||:.||.|||.||:||||:|||:||:|:|
Frog   191 PELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIR 255

  Fly   483 KFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYI--------EPKADLADPKRIEALVAMGYNR 539
            ..|||.|:||.|:|.|...|||..|.::.|.:..|        |.:.|..:.:.:..:|.||.:|
Frog   256 HMLVLEPSKRLSMEQICKHKWMCQGEQDLEFERLIAECQHVKLERQRDPLNEQVLLTMVEMGLDR 320

  Fly   540 SEIEASLSQVRYDDVFATYLLLG---------RKSTDPESDGSRSGSSLSLR-NISGNDAGANAG 594
            .....||....||...|.|.||.         |..|.|.:..:.|.|:.|:: :.:.|....|..
Frog   321 ERTLQSLRTDAYDHYSAIYSLLCDRLKRHKTLRLPTQPSAPRTVSYSTPSVQADAASNTVSINVP 385

  Fly   595 SASVQSPTHR-----GVHRSISASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYNAAG 654
            ...:.:|.::     |.....|..:.:||        |...|..::.....||.   .:.:|.:|
Frog   386 QVQLINPENQIVETNGTMTLDSDEAEEPS--------PEALARYLSMRRHTVGV---PDTHNESG 439

  Fly   655 SAADRASVGSNFKR-QNTIDSATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKY 718
            : .:...:...|.| ...|....:.:||..|......|.||   .|...:.:|..|...:.....
Frog   440 T-DELQKIFPGFPRVTQQIPFLPVTQNTNVLHTLLPMPPSA---HLEYKEQSLLQPPTLQLLNGM 500

  Fly   719 DPTNGNRTVSGTSGI---------IPRRSTTLYEKTSSTEKTNVIPAETNLFD------RLRMAS 768
            .|. |.|...|.:.|         .||..:.|.  |.:|..|.|.|.:....|      .::...
Frog   501 GPL-GRRASDGGANIQMHAQLLLKRPRGPSPLV--TMATTVTAVTPVDEESSDGEPDQEAVQRYL 562

  Fly   769 AVKSSRHF------PRNVPSRSTFHSGQTRARNNTAL------EYSGTSGASGDSSH-PGRMSFF 820
            |.::.||.      ...:|.......||.:|..|.|.      :...:.....::.| |
Frog   563 ANRTKRHTLAMTSPTAEIPPELQRQLGQQQAFRNRAWPPHLAPDLHRSMYKDSNTLHLP------ 621

  Fly   821 SKLSSRFSKRPTIADEAAKPRVLRFTWSMKTTSPLMPDQIMQKIREV-------LDQNNCDYEQR 878
               :.|||.....:|.||..:..:..............|:.|:..::       :|:...::.|:
Frog   622 ---AERFSPVRRFSDGAATIQAFKAHLEKMGNQNSSIKQLQQECEQLQKMYGVHMDERTLEHTQQ 683

  Fly   879 ERFVLWCVHGDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIGFKNIASRIAFDL-KLXLNQ 942
            :..:....|    ...|:|.:|:.|..|......::...::..|   :|..:.:...| :|.:..
Frog   684 QHVMYQHEH----QHHLLQQQIQDCIRPAQPSPPLQSSSMTPAS---ENQPALLTHQLQRLRIQP 741

  Fly   943 TNNEGNAAAT------ASRPTDPTDTM-----TTTNCRRPSNDSTSRLSELS---------LLCR 987
            ::...|.|:.      .|.|...:..|     .|::.:.|...:.|.:.:.|         .|.|
Frog   742 SSPPPNPASNHLFRQPNSSPPPSSSAMLQTHGATSSSQYPGMPTHSSIYQPSSTGSPPPSMALPR 806

  Fly   988 SLTSQQGSQRRKKSRLS---------TGGSE-----------DQKKSNSLLSAFQMYS--PFSSK 1030
            ....||.||::...:::         .|.|.           ..::..||:|:...||  |. ||
Frog   807 MSIQQQQSQQQSPQQVTIQVQEASDLPGASRGMPIIPCANHIQMQQRASLMSSMGNYSHRPL-SK 870

  Fly  1031 ENMQSSEEVEDLHVIDTQPGHSVDVP-----LFADFSPINPIMEEDAEGVEGGKTSEAKVISGGS 1090
            :....:.||..|::....|..:.|..     :||: .|..|               .|...|.||
Frog   871 QLSADNAEVHSLNMAHFSPSTNYDQTHLHPHVFAE-QPRPP---------------PAVYTSTGS 919

  Fly  1091 GQKVKGDGGG 1100
            |.   |..||
Frog   920 GY---GPSGG 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	173/251 (69%)
		S_TKc	253..504	CDD:214567	173/250 (69%)
		UBA_MARK_Par1	525..563	CDD:270522	12/46 (26%)
		MARK1-3_C	839..936	CDD:213381	12/103 (12%)
sik3	XP_004916140.2	STKc_SIK	25..277	CDD:270973	173/251 (69%)
sik3	XP_004916140.2	UBA_SIK3	306..350	CDD:270593	12/43 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910