DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment par-1 and prkaa2

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001135554.1	Gene:	prkaa2 / 100216099	XenbaseID:	XB-GENE-5994580	Length:	551	Species:	Xenopus tropicalis

Alignment Length:	320	Identity:	139/320 - (43%)
Similarity:	203/320 - (63%)	Gaps:	13/320 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 IGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQL-NPGSLQKLFREVRIMKMLDHPNIV 313
            ||.|.|..|:|.|.|.|||:.:|..||.:||:||:::.:: |...:.|:.||::.:|:..||:|:
Frog    13 IGHYILGDTLGVGTFGKVKMGEHQLTGHKVAVKILNRQKIRNLDVVGKIKREIQNLKLFRHPHII 77

  Fly   314 KLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKA 378
            ||:|||.|....:::|||.||||:|||:..|||::|.|||..|:||:|||.|||:..::|||||.
Frog    78 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEAEARRLFQQIISAVDYCHRHMVVHRDLKP 142

  Fly   379 ENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 443
            ||:|||:.:|.||||||.||..:.|..|.|.||||.|||||:..|:.|.|||||:||.|||||.|
Frog   143 ENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYAL 207

  Fly   444 VSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGF 508
            :.|:||||...:..|.:::..|.:.||.|::.....||...|.::|.|||:::.|...:|    |
Frog   208 LCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSAATLLMHMLQVDPLKRATIKDIREHEW----F 268

  Fly   509 EEDELKPYIEPK-----ADLADPKRI-EALVAMGYNRSEIEASL-SQVRYDDVFATYLLL 561
            ::| |..|:.|:     |::.|.:.: |.........||:..|| |....|.:...|.|:
Frog   269 KQD-LPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLI 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	120/252 (48%)
		S_TKc	253..504	CDD:214567	120/251 (48%)
		UBA_MARK_Par1	525..563	CDD:270522	10/39 (26%)
		MARK1-3_C	839..936	CDD:213381
prkaa2	NP_001135554.1	STKc_AMPK_alpha	13..268	CDD:270981	123/258 (48%)
		UBA_AID_AAPK2	285..349	CDD:270587	11/43 (26%)
		AMPKA2_C	395..549	CDD:213385
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000