Protein Alignment par-1 and sik2

DIOPT Version :10

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: XP_002932962.2
• Gene: sik2 / 100125196
• XenbaseID: XB-GENE-950070
• Length: 899
• Species: Xenopus tropicalis
• Alignment Length: 907
• Identity: 282/907 - (31%)
• Similarity: 416/907 - (45%)
• Gaps: 218/907 - (24%)

  Fly   250 IGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVK 314
            :|.|.:.:|:||||||.||||:|..|..|||||||||:||:..:|:|::|||:||||||||:|:|
 Frog    17 VGFYDIERTLGKGNFAVVKLARHRITKTEVAIKIIDKSQLDSVNLEKIYREVQIMKMLDHPHIIK 81

  Fly   315 LFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAE 379
            |:||:||:..|||:.|||..||:||||..|||:.|.|||.||.||:|||:|||.:.|:|||||||
 Frog    82 LYQVMETKNMLYLVTEYAKNGEIFDYLANHGRLNEPEARRKFWQILSAVEYCHGRNIVHRDLKAE 146

  Fly   380 NLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLV 444
            |||||:.:|||||||||.|.:..|..|.|:||||||||||:|:|::|:||::|:||:||:||.||
 Frog   147 NLLLDNHMNIKIADFGFGNFYKNGEPLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLV 211

  Fly   445 SGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFE 509
            .|:|||||.||..||:|||.|::|||::||.:||:|:|:.|||.|:||.|:..|...|||..  |
 Frog   212 CGALPFDGPTLPILRQRVLEGRFRIPYFMSEECEHLIRRMLVLEPSKRLSIAQIKEHKWMMA--E 274

  Fly   510 EDELKPYI-----EPKADLAD--PKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTD 567
            ....:|.:     :..|.:.:  .:.:..:.::|.::.:...||....|:...|.|.||..:
 Frog   275 VPVHRPVLYSQTQDKAASIGEYNEQVLRLMHSLGIDQQKTIESLQNRSYNHFAAIYYLLVER--- 336

  Fly   568 PESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRG---VHRSISASSTKPSRRASSGVGPTN 629
                                            ..:||.   |...|.|...:||         |.
 Frog   337 --------------------------------LKSHRSSFPVESRIDARQRRPS---------TV 360

  Fly   630 AAATVAAATGAVGAVN--PSN------------------NYNAAGSAADRASVGSNFKRQNTIDS 674
            |..||..|:..|..||  |.|                  :|....|.|:     |.|..:.::::
 Frog   361 AEQTVTKASTIVPPVNLLPQNMRLLRAPILPEASPAETFSYPQISSQAE-----STFLEEESVNT 420

  Fly   675 -------------ATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRT 726
                         .||::....|......  ::..:.:.|.|.|...||:...|.:     |.|
 Frog   421 PPVNGCLLDPLPPVTIRKGCQSLPCNMME--TSIDEGIETEDDTEEDPAQAFAACQ-----GRR- 477

  Fly   727 VSGTSGIIPRRSTTLYEKTSSTEKTNVIPA-----ETNLFDRLRMASAVKSSRHFPRNVPSRSTF 786
                ||   :|..||.|.|:   :..::|:     |..||
 Frog   478 ----SG---QRRHTLSEVTN---QMVMLPSGGPDMEGKLF------------------------- 507

  Fly   787 HSGQTRARNNTALEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPTIADEA-AKPRVLRFT---W 847
                 ...||.:|       .|.||.: ...|..|.||  |....|:.:.. |...|.|.|   .
 Frog   508 -----TIGNNPSL-------GSVDSEY-DMGSIQSDLS--FQDDGTMNEVVMANQSVTRLTPPFI 557

  Fly   848 SMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGDPN-TDSLVQWEIEVCKLPR---- 907
            .::.|:..||....|| ||..:::...:.:..|      ..|.: |..:|.:...:..|.|
 Frog   558 GLRPTNLAMPTLPSQK-REAHNRSPVSFREGRR------ASDTSLTQGIVAFRQHLQNLARTKGI 615

  Fly   908 LSLNGVR-FKRISGTSIGFKNIASRIAFDLKLXLNQTNNEGN-----AAATASRPTDPTDTMTTT 966
            |.||.:: |....|.. ..:|:.|        ..||..:..:     :|..::..|.|.......
 Frog   616 LELNKIQMFYEQMGPD-EEQNVTS--------VPNQLQDHNHHPLDMSAQLSNVSTFPNGIHPHL 671

  Fly   967 NCRRPSNDS---TSRLSELSLLC--------------RSLTSQQGSQRRKKSRLSTGGSEDQKKS 1014
            ..||.|.::   ..||.:.:||.              |||..|....|..:.||..      :|.
 Frog   672 LSRRQSLETQYLQHRLQKANLLAKAQNSCQLYCKETPRSLEQQLQEHRLHQKRLFL------QKQ 730

  Fly  1015 NSLLSAFQMYSPFSSKENMQSSEEVEDLHVIDTQPGHSVDVPLFADFSPINPIMEEDAEGVE 1076
            ..|.:.|:......:...|| ::::...|....||..      |....|::|:||..::.::
 Frog   731 PQLQAYFKQMQIAETSYPMQ-TQQLPLSHQETVQPAQ------FGLSQPLSPVMEPASDEMQ 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	156/251 (62%)
		UBA_MARK_Par1	525..563	CDD:270522	8/39 (21%)
		MARK1-3_C	839..936	CDD:213381	23/105 (22%)
sik2	XP_002932962.2	STKc_SIK	19..271	CDD:270973	156/251 (62%)
		UBA_SIK2	297..341	CDD:270592	8/78 (10%)