DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and chek1

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_002937561.2	Gene:	chek1 / 100038224	XenbaseID:	XB-GENE-491846	Length:	474	Species:	Xenopus tropicalis

Alignment Length:	547	Identity:	138/547 - (25%)
Similarity:	229/547 - (41%)	Gaps:	124/547 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 YKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLN--PGSLQKLFREVRIMKMLDHPNIVKL 315
            :.|::|:|:|.:.:|:||.:..|.:.||:||:|.|:..  |.:::|   |:.|.:||:|.|||:.
Frog     9 WDLVQTLGEGAYGEVQLAVNRKTEEAVAVKIVDMTRAADCPENIKK---EICINRMLNHTNIVRF 70

  Fly   316 FQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAEN 380
            :.........||.:||..|||:||.:.....|.|::|:..|:|:::.|:|.|...|.|||:|.||
Frog    71 YGHRREGNIQYLFLEYCRGGELFDRIEPDVGMPEQDAQKFFQQLIAGVEYLHSIGITHRDIKPEN 135

  Fly   381 LLLDSELNIKIADFGFSNEFTPGSK---LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYT 442
            ||||...::||:|||.:..|...:|   |:..||:.||.||||.:.:.::...|||||.|::|..
Frog   136 LLLDDRDHLKISDFGLATVFRHNAKERLLNKMCGTLPYVAPELIKSRAFNAEPVDVWSCGIVLTA 200

  Fly   443 LVSGSLPFDGST--LRELRERVLRGKYRIPF-YMSTDCENLLRKFLVLNPAKRASLETIMGDKWM 504
            :::|.||:|..|  .:|..:...:..|..|: .:......||.|.|..||..|.::..|..|:|
Frog   201 MLAGELPWDQPTEACQEYCDWKEKNHYLTPWKKIGATPLALLCKMLTENPQSRITIPDIKKDRW- 264

  Fly   505 NMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPE 569
               |.|                     |:..|..||
Frog   265 ---FTE---------------------LIKKGIKRS----------------------------- 276

  Fly   570 SDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAATV 634
                        |..||..:.::.....::|    .:..||.:.|.:.:..:|:...|..|.||
Frog   277 ------------RAFSGGTSDSSGLCKQIRS----DMEISIISHSEEKNAYSSTQPEPRTALAT- 324

  Fly   635 AAATGAVGAVNPSNNYNAAGSAADR--ASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQK 697
                           :::.||..|.  ...|.:|.:....::..:..........:|.......|
Frog   325 ---------------WDSNGSHIDNLVQGKGISFSQPACPENMLLSSQLIGTPGSSQNVWQRLVK 374

  Fly   698 MLTTADTTLNSPAKPRTATKYDPTNGNRTVSGT---SGIIPRRSTTLYEKTSSTE--------KT 751
            .:|            |..||.|..:....:..|   .|.:.::|.......|:|:        |.
Frog   375 RMT------------RFFTKVDAESSYSNLMDTCEKMGYVLKKSCANQVTLSTTDRRNNKLIFKV 427

  Fly   752 NVIPAETN-LFD-RLRMASAVKSSRHF 776
            |::..|.. |.| ||.....::..|||
Frog   428 NLVEMEDRILLDFRLSKGDGLEFKRHF 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	92/258 (36%)
		S_TKc	253..504	CDD:214567	92/258 (36%)
		UBA_MARK_Par1	525..563	CDD:270522	4/37 (11%)
		MARK1-3_C	839..936	CDD:213381
chek1	XP_002937561.2	STKc_Chk1	7..265	CDD:270971	93/262 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D698464at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010