Protein Alignment par-1 and mark2b

DIOPT Version :9

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: XP_009301419.1
• Gene: mark2b / 100005996
• ZFINID: ZDB-GENE-080215-4
• Length: 790
• Species: Danio rerio
• Alignment Length: 852
• Identity: 419/852 - (49%)
• Similarity: 527/852 - (61%)
• Gaps: 173/852 - (20%)

  Fly   196 TPGSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWR---ATEE---HIGKYK 254
            |...|||...|.:            .|..|.|||.    :||||| |.|   ||.|   |||.|:
Zfish     3 TRPQGVAVIENSS------------SQTHSDAKGG----VRSSAP-RCRNAVATAEEYPHIGNYR 50

  Fly   255 LIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVI 319
            |:||||||||||||||:|:.|.||||:|||||||||..||||:||||||||:|:||||||||:||
Zfish    51 LLKTIGKGNFAKVKLARHVLTSKEVAVKIIDKTQLNSSSLQKVFREVRIMKLLNHPNIVKLFEVI 115

  Fly   320 ETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLD 384
            ||:|||||:||||||||||||||.||||||||||.|||||||||||||||.|:||||||||||||
Zfish   116 ETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLD 180

  Fly   385 SELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLP 449
            :::||||||||||||||.|:|||||||||||||||||||||||||||||||||||||||||||||
Zfish   181 ADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLP 245

  Fly   450 FDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLE-TIMGDKWMNMGFEEDEL 513
            |||..|:|||||||||||||||||||||||||:|||:|||.||.||| .||.|:|||:|:|:|:|
Zfish   246 FDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPTKRGSLEQQIMKDRWMNVGYEDDDL 310

  Fly   514 KPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSS 578
            ||||||:.|..||:|.:.::.||:::.|||.||.:.:|::|.||||||..::::.:     .|.:
Zfish   311 KPYIEPQPDYKDPRRTDIMLQMGFSQEEIEDSLVKQKYNEVMATYLLLDYRNSELD-----EGVN 370

  Fly   579 LSLRNISGND-AGANAGSASVQSPTHRGVHRSISASSTKPSRRAS-------------------S 623
            |||::..|:| ..:||     .||.|: |.||:| |:.||:||::                   |
Zfish   371 LSLKSRPGSDLTNSNA-----PSPPHK-VQRSVS-STQKPARRSTDQGSYSKRPQGENKHGVEDS 428

  Fly   624 GVGPTNAAATV--------------AAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTIDS 674
            |...::::..|              ..:|.::.:...|.:.|:  ..::||::|.    ||..||
Zfish   429 GRKGSSSSTKVPPSPVISSERKKSSTPSTNSILSTGTSRSRNS--PISERATLGV----QNGKDS 487

  Fly   675 ATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTAT--KYDPTNGNRTVSGTSGIIPRR 737
            .:...:.|..|:.....:|::....|....:|::.|.|..|.  .:.|::..:...|.|     .
Zfish   488 LSTPGSRASTASAGPVLSSSSSSSRTRHHKSLSTSAHPSPADLHSHRPSDPPQRAPGAS-----P 547

  Fly   738 STTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTR-ARNNTALEY 801
            |.......:.|::||                       |||.||:|:|||.||.| ||:.....|
Zfish   548 SAHNISSAAGTDRTN-----------------------FPRGVPTRNTFHLGQQRGARDQQGSPY 589

  Fly   802 SGTSGASGDSSH-------PGRMSFFSKLSSRFSKR----------------------------- 830
            .| :.||...||       |.....|||.:|:|.:|
Zfish   590 HG-APASPSLSHGNSQQRRPAASGIFSKFTSKFVRRNLSFRFPRRSPYEGEGQEEGSRSMLSSAE 653

  Fly   831 ------------------------PTIA-----DEAAKPRVLRFTWSMKTTSPLMPDQIMQKIRE 866
                                    |..|     .:.:|||.|||||||||||.:.|.::|::||:
Zfish   654 KSEKTSVGPEDENKDPSSSPGGGTPPAAPVSSLKDQSKPRSLRFTWSMKTTSSMEPSEMMKEIRK 718

  Fly   867 VLDQNNCDYEQRERFVLWCVHGDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIGFKNIASR 931
            |||.|:|:||.|||::|.|:.|:|..|..||||:|||||||||||||||||||||||.||||||:
Zfish   719 VLDANSCEYELRERYMLLCMAGNPARDDFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASK 783

  Fly   932 IAFDLKL 938
            ||.:|||
Zfish   784 IANELKL 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	216/252 (86%)
		S_TKc	253..504	CDD:214567	216/251 (86%)
		UBA_MARK_Par1	525..563	CDD:270522	18/37 (49%)
		MARK1-3_C	839..936	CDD:213381	68/96 (71%)
mark2b	XP_009301419.1	STKc_MARK	48..301	CDD:270974	216/252 (86%)
		S_TKc	49..301	CDD:214567	216/251 (86%)
		UBA_MARK2	319..360	CDD:270589	19/40 (48%)
		AMPKA_C_like	691..789	CDD:302605	68/97 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	459	1.000	Domainoid score	I467
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	743	1.000	Inparanoid score	I569
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	1	1.000	-	-		otm25828
orthoMCL	1	0.900	-	-		OOG6_101232
Panther	1	1.100	-	-	O	PTHR24346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.860