DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and mark1

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001107948.1	Gene:	mark1 / 100003170	ZFINID:	ZDB-GENE-070626-2	Length:	772	Species:	Danio rerio

Alignment Length:	805	Identity:	433/805 - (53%)
Similarity:	510/805 - (63%)	Gaps:	109/805 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 PTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEE--HIGKYKLIKTIGKGNFA 265
            ||||:.....|::.........:..|.|....:..|.......|:|  |:|.|:|:|||||||||
Zfish     8 PTVNERDAENHTSVDGYTDTPAAPTKSSSRQSLPRSRNSVASITDEQPHVGNYRLLKTIGKGNFA 72

  Fly   266 KVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIME 330
            |||||:|:.||:|||:||||||||||.|||||||||||||:|:||||||||:|||||||||||||
Zfish    73 KVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLIME 137

  Fly   331 YASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFG 395
            ||||||||||||.||||||||||.|||||||||||||||||:||||||||||||:::||||||||
Zfish   138 YASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFG 202

  Fly   396 FSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRE 460
            ||||||.||||||||||||||||||||||||||||||||||||||||||||||||||..|:||||
Zfish   203 FSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRE 267

  Fly   461 RVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLAD 525
            |||||||||||||||||||||:|.|||||.||.|||.||.|.|:|:|.||:|||||.||:.|.:|
Zfish   268 RVLRGKYRIPFYMSTDCENLLKKLLVLNPGKRGSLEQIMKDHWINVGHEEEELKPYTEPEPDFSD 332

  Fly   526 PKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAG 590
            .||||.::.||:.:.||..:|...:||:|.|||||||||  .||.:||.|.|:.:|...|...:.
Zfish   333 TKRIELMITMGFPKDEITEALVGQKYDEVMATYLLLGRK--PPEFEGSDSLSTTNLCQRSRPSSD 395

  Fly   591 ANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPT--------------------------- 628
            .|  ::|.|||.|..|.|||||  |:..||.|..|.|:
Zfish   396 LN--NSSSQSPAHSKVQRSISA--TQKQRRFSDHVAPSIPPAVSYTKRSQANSVEGEKKEEWDAS 456

  Fly   629 -----------NAAATVAA--------ATG--AVGAVNPSNNYNAAGSAADRASVGSNFKRQNTI 672
                       .||:.:||        |:|  |.|.:...|.|....|:.||.|...|.|..:..
Zfish   457 RKLPSSSSKGDMAASPLAAQERRKSSTASGNSAAGGMTRRNTYVCERSSTDRYSAIPNGKDSSLT 521

  Fly   673 DSATIKENTARL-----AAQNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSG 732
            :.:|....|:.:     |..:.||...  |.::.:.....||        ..|...|....|:..
Zfish   522 EMSTSGSGTSSVSPGASALSSTRPRHV--KSMSASGHPNKSP--------LPPIEDNTEFKGSGS 576

  Fly   733 IIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTRARNNT 797
            ..|..|.:.:..:|.|.            ||.|          |||...||||||..|.|.|.:.
Zfish   577 RAPSTSPSAHSISSMTP------------DRTR----------FPRGTSSRSTFHGAQLRDRRSA 619

  Fly   798 ALEYSG---------TSGASGDSSHPGRMSFFSKLSSRFSKR-----PTIADEAAKPRVLRFTWS 848
            .  |:|         .:||...:.......|.|||:|:|.:|     |......:|||.||||||
Zfish   620 T--YNGPPASPTLSHDTGALAQARRGTSSGFISKLTSKFVRRSGSGEPKEDGRDSKPRSLRFTWS 682

  Fly   849 MKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQWEIEVCKLPRLSLNGV 913
            |||||.|.|..:|::||:|||.|||||||||||:|:|||||...|||||||:|||||||||||||
Zfish   683 MKTTSSLEPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDARHDSLVQWEMEVCKLPRLSLNGV 747

  Fly   914 RFKRISGTSIGFKNIASRIAFDLKL 938
            ||||||||||.||||||:||.:|||
Zfish   748 RFKRISGTSIAFKNIASKIANELKL 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	222/251 (88%)
		S_TKc	253..504	CDD:214567	222/250 (89%)
		UBA_MARK_Par1	525..563	CDD:270522	19/37 (51%)
		MARK1-3_C	839..936	CDD:213381	77/96 (80%)
mark1	NP_001107948.1	STKc_MARK	59..311	CDD:270974	222/251 (88%)
		S_TKc	60..311	CDD:214567	222/250 (89%)
		UBA_MARK1	331..371	CDD:270588	20/39 (51%)
		MARK1-3_C	673..770	CDD:213381	77/96 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8588
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	743	1.000	Inparanoid score	I569
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	1	1.000	-	-		otm25828
orthoMCL	1	0.900	-	-		OOG6_101232
Panther	1	1.100	-	-	LDO	PTHR24346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.960