DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mute and Gon4l

DIOPT Version :9

Sequence 1:	NP_001097352.1	Gene:	mute / 2768848	FlyBaseID:	FBgn0085444	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	XP_036019277.1	Gene:	Gon4l / 76022	MGIID:	1917579	Length:	2261	Species:	Mus musculus

Alignment Length:	2283	Identity:	436/2283 - (19%)
Similarity:	715/2283 - (31%)	Gaps:	855/2283 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AKKSDSAKSNSSTPRRPRKRKRVDRQSL--DSQVDEDAKEIDRRLRKVAKKNSISAEDMQKVVRK 67
            :::||..|......:|.|..|..::.::  |.::|:   .:||.|...||:::::|.:::.::.:
Mouse   237 SEESDKKKKTKKGTKRKRDGKGPEQGTMVYDPKLDD---MLDRTLEDGAKQHNLTAVNVRNILHE 298

  Fly    68 VVRNDHVLALVTLKAEDELAREKLESAEQQKRGAIIIT-DTPSV-PKLTRAKARELNCTPGISLP 130
            |:.|:||:|::                    :.||..| |.|.. ||:||:|.:|: ...|:.:|
Mouse   299 VITNEHVVAMM--------------------KAAISETEDMPLFEPKMTRSKLKEV-VEKGVVIP 342

  Fly   131 QLN--------ETSTDNNGIEALIREDLHSDEEDEEYTFKEEDFHSDDDPNTTASDFDSNPCTPQ 187
            ..|        |.......::..:.||   |..||||:..||:.....:.:...||.:|...:|:
Mouse   343 TWNISPIKKASEIKQPPQFVDIHLEED---DSSDEEYSPDEEEEDETAEESLLESDVESTASSPR 404

  Fly   188 ------------------------------TPLTANEESPI-----------KFSDDGCFKVPLD 211
                                          ||...:..:.:           |.|.|..|...||
Mouse   405 GVKRSRLRLSSEVAETDEESGMLSEVEKAATPALRHISAEVVPMGPPPPPKPKQSRDSVFMEKLD 469

  Fly   212 R-------------NFQDKEDLRIATRTRSKFCLQQTTIEDLQSEFVPPDVEPSDVVENEMTAND 263
            .             :||..||..||.|||||..|:...:..|::|...||:.|.....|  ||:|
Mouse   470 AVDEELASSPVCMDSFQPMEDSLIAFRTRSKMPLKDVPLGQLEAELQAPDITPDMYDPN--TADD 532

  Fly   264 ADWMQFL----NDFTKPLNNTVQGDDDDPINDPEYVAADHL-ESEYENAEELRDVNISKKELTDL 323
            .||.|:|    ||   .:.|..:.||||   ||||...:.| |.:.|:....|.|.|:|||:..|
Mouse   533 EDWKQWLGGLIND---DVENEDEADDDD---DPEYNFLEDLDEPDTEDFRTDRAVRITKKEVNGL 591

  Fly   324 VSELFAGLLEEGVSLESIELETPQKFVESANVSMIPIDQVSRNIDFDGQQINANQQELSVFQPNL 388
            :.|||          |:::...|.||.:....|         |::.||.:   .::..:..:|:.
Mouse   592 MEELF----------ETVQSVVPSKFQDEMGFS---------NMEDDGPE---EEERATESRPSF 634

  Fly   389 MPPPCEGNEMGMGVPVPVAVLQEETGGSACNVVNIPSEALTVPPELIAVPIPGQPNCFQIAKVVG 453
                          ..|.|:..||.      :.|:.:|......||:
Mouse   635 --------------NTPQALRFEEP------LANLLNERHRTVKELL------------------ 661

  Fly   454 NDSTVGLPLTEETLQNFSSLHPMEPPVVAASNGDRYKKPFDTNFTWEYISVRKHIYSEYEEKFES 518
                       |.|                    :.|||          |||:      :.:.|.
Mouse   662 -----------EQL--------------------KMKKP----------SVRQ------QPEVEK 679

  Fly   519 LRNVEPVNLNHLARSRGFTQSQHDMLQQQLRIHTQLLSQSYLQTYSHPTLYPMAKKPREMLEELH 583
            |:..|......|.    ...:|...||||::.|.|||:|.||.|.|:|.|...|...|..|:||.
Mouse   680 LKPQEEAAHQTLV----LDPAQRSRLQQQMQQHVQLLTQIYLLTTSNPNLSSEASTTRIFLKELG 740

  Fly   584 KMATK--------DPSFN-----CWNLQEAVQLVRKWEHDLSSDEFKEENEKMMDFINKETDLTD 635
            ..|..        :|.|.     | |...|::|:.                   ||.....|.:.
Mouse   741 TFAENSIALHQQFNPRFQTLFQPC-NWMGAMRLIE-------------------DFTQVSIDCSP 785

  Fly   636 GHT-----RQVPRLAPRIMDLMLDSRVFMYPQYLP---RMAFQPKLTQTTAYAPSEYQLIAIGLE 692
            ..|     .:.|.|..::..::..::|||||:.||   ..|..|:  ..|.:..:|..|:|:||
Mouse   786 HKTAKKTASEFPCLPKQVAWILATNKVFMYPELLPICSLKANNPR--DKTIFTKAEDNLLALGL- 847

  Fly   693 KHLALMVKAKRQLRKGAD-PIRVACKRMIKDTICGKTARRIFLKIAELRNSKQYNPVKYFFE--- 753
            ||.           :|.: |..:..|.::   .| |||.::.::|..|..::..|.|..|::
Mouse   848 KHF-----------EGTEFPKPLISKYLV---TC-KTAHQLTVRIKNLNLNRAPNNVIKFYKKTK 897

  Fly   754 --------------HRRAPP-----------------------ANAILWGFAGGLVRTPRE---- 777
                          |:..||                       .|.......||.|.|..|
Mouse   898 QLPVLVRCCEEIQPHQWKPPFEKEEHRLPFWLKASLQSIQDELRNISEGATEGGSVTTATESSTD 962

  Fly   778 RHME-----------------------LPSGWQYYIEKTWDQKR--------------TRRNFKA 805
            :|::                       |..|.:.:..|.|.|||              .:..|..
Mouse   963 QHLQKASPALGDEPQYPLLLPKGVVLKLKPGSKRFSRKAWRQKRPLVQKPLLIQPSPSVQPVFNP 1027

  Fly   806 SKASS-------------------VASASYLE----FVREAV-GED-----LLLPETFGQAAVPN 841
            .|.::                   :..|:.|:    |....| |||     ..||      |:|.
Mouse  1028 GKMATWPTQSEVPPSNTVVQIPHLIQPAAVLQTLPGFPSVGVRGEDGFESPTALP------AMPC 1086

  Fly   842 GSAA---------GSEPPKESKPK-----------------KRPAQR---------RPRPAENP- 870
            ||.|         .|.||..|.||                 ::|.:|         :|.|..:|
Mouse  1087 GSEARTTFPLSETQSAPPSCSAPKLMLPSLAPSKFRKPYVRRKPTRRKGAKVSPCVKPAPIIHPT 1151

  Fly   871 ------PQLTINVNYVFGG-----NTSAG------------------------NIPGVSGVSVPL 900
                  |..|:.|..:.||     ..||.                        |.|.|:....||
Mouse  1152 PVIFTVPATTVKVVSIGGGCNMIQPVSAAVAPSPQTIPITTLLVNPTTFPCSLNQPLVASSISPL 1216

  Fly   901 VAGGN--------LAENVLNIN-----------------------------------RSLYTAAE 922
            :...|        :.|:...:.                                   :|.:::|:
Mouse  1217 IVSSNPLTLPVTSIPEDKAQVKLDVAEGKNAPQNPESKLKPQELTPLCTTVFSKEEPKSWHSSAD 1281

  Fly   923 CSSLLALPP-----------------------------------APPPLDENAPPAINFTVDKFT 952
            ..|..|...                                   |..||.:|...:::.:.....
Mouse  1282 TGSQEAFSESSACSWAVVKTESQEGSSEKSACGWTVVKTEDGGHAVEPLPQNLQDSLSSSSKDLL 1346

  Fly   953 NTL----QICELEESSKAVQPDL-------------------------------------LPAQD 976
            |.:    |.|.:|.||...:.|:                                     :.|..
Mouse  1347 NMVKMEAQDCMVEISSNFPKQDIGEEVKEECSMELDSESPQEKPSSASEMSKQTVLQREDMQAAK 1411

  Fly   977 TPSVP------GRNAKRARYQIFKPKV-----------------QSANKSRKG-STPTRSRYHIL 1017
            :||||      ||.:..|...:.|..:                 .|||...:. .||........
Mouse  1412 SPSVPQDAAAEGRTSSHASRGLPKSTLSSMGQGGGLSGPPGKLEDSANADGQSVGTPAGPDTGGE 1476

  Fly  1018 RERLRHKLSQRCHSLITTYESYLRHHIEKYKDCELVQVVHNRFFALELYTQLLVDLRMFCSNTNS 1082
            ::....:..:....|....|..|....|     |.|..|......:|..|.|..:.||.....:.
Mouse  1477 KDGPEEEEEEDFDDLTQDEEDELSSASE-----ESVLSVPELQETMEKLTWLASERRMSQEGESE 1536

  Fly  1083 KTAAQPKRS----RSDDEAAKLRRANRQEEMLRQ------------MLQPDTTEE---------- 1121
            :..:|.:.|    ..::||..:....:::|:..:            :..|.|..|
Mouse  1537 EENSQEENSEPEEEEEEEAEGMETLQKEDEVNDEAVGDAAKKPPSTLASPQTAPEIETSIAPAGE 1601

  Fly  1122 ---------------------------------------------RNRKDAIFAMNFYEKVEEAL 1141
                                                         |.:||..||..:..:|.|||
Mouse  1602 SIKAAGKGRSSHRARNKRGSRARASKDTSKLLLLYDEDILDRDPLREQKDLAFAQAYLTRVREAL 1666

  Fly  1142 L-SANRLDDCKKFNSILQNFDPRQEKVSSLYL-KVEEILLPTHPELAEVFLNFLLPAEAAEMGKF 1204
            . :..:.:|   |..|:..|:...:..|::.| |..:.||...|:|.:.|..||||.:|...|.|
Mouse  1667 QHTPGKYED---FLQIIYEFESSTQMHSAVDLFKSLQTLLQDWPQLLKDFAAFLLPEQALSCGLF 1728

  Fly  1205 FEHFMICNATNFINKLNIYFSKQPAQIRKIYACLNELAEMPNVSMKKVENKIMPLLKGNQFLIDW 1269
            .|......:..|:.:|.|.|::.|:..:||...|...|:.....:.:::.::..||:|:..|.|.
Mouse  1729 EEQQAFEKSRKFLRQLEICFAENPSHHQKIIKVLQGCADCLPQDIAELKTQMWQLLRGHDHLQDE 1793

  Fly  1270 FVQQFPQGKPPKRILSPVETINLHDVQNNTTGEYTETIQEFTDVPTPSKPGCHLKYINGRIFYGA 1334
            |...|...:|....:...|.||..:.:......:.|.|  ..||....:|              |
Mouse  1794 FSIFFDHLRPAASRMGDFEEINWTEEKEYEFDGFEEVI--LPDVEEDEEP--------------A 1842

  Fly  1335 KILLPAKLSFMAASIYNEQSHDV--PPVSSD-SINCAHG-------------------------- 1370
            |:...:|...........|..|.  |..:.| |.:|..|
Mouse  1843 KVSTASKSKRRKEIGVQHQDKDTEWPEAAKDCSCSCHEGGPESKLKKSKRRNCHCSSKVCDSKPY 1907

  Fly  1371 -------IRAQG--EKLLSMASNTDSDDGADRSEED--------DASRALIIDTTSDEQ------ 1412
                   :...|  .:..::..:.::..|.|..||:        :.:::....||...:
Mouse  1908 KSKEPPELVGSGPLHEASTVPGSKEAGQGKDMLEEEILEEQENMEVTQSKTARTTRKGEAPAPAG 1972

  Fly  1413 NSCSSIEMCDETGLRAHAIRLNPGLYTNSSFNNAATSTPNLGNSHQSHHPHAKKTAINFGEISPR 1477
            ::..|..:|.........:...|.|        .:..||.|     .....|...::...:..|.
Mouse  1973 STIGSTLLCPAEVTPMELLLEGPAL--------CSAETPRL-----PPQTGAVVCSVRRNQAGPE 2024

  Fly  1478 KQSAFNNSGLSPLSAAPNSSPQVDKRKSPTKKIRSPLNQTQSRQRANNQPMVVIHESQPSSSPAI 1542
            ..|..:.|.|.|....       |:|.:...:..:|..:....:|.   |..|.| |.|..||..
Mouse  2025 VVSCLSTSSLPPEEGE-------DQRAAANSETIAPHREASETERL---PETVEH-SAPLPSPVS 2078

  Fly  1543 E----------CAK--RLRTLIDQESVRDAADTKAGIRIIAQAKQQPPNQCSSEAITKV--EVVS 1593
            .          |.|  ....||:..:..:||      .:.|...::.....:|||..|.  ||::
Mouse  2079 TRTRDTGRRHICGKAGSQSWLIESRAEAEAA------HVAAPICEKSSGARASEAAPKTAREVLA 2137

  Fly  1594 LDESAENMPFCTNLKMDTDQSEEELEPLQLSAGNTPQHVITTQFDSDEDCKLDVVATLANCTTTE 1658
            .|...:.|.                     ..|..|:
Mouse  2138 EDSGTQGMG---------------------PEGALPK---------------------------- 2153

  Fly  1659 DRSESAAALPATTSHSESGSSHSAPWTREEDKVIL-IEMKIGARDREQLIRRMRAKLKNRSIEEL 1722
               .|.|.:.|..|...|.......||||.|:||| :..:.||:.....:  :..:|.|::..|:
Mouse  2154 ---ASEATVCANNSKVSSTGEKVVLWTREADRVILTMCQEQGAQPHTFSV--ISQQLGNKTPVEV 2213

  Fly  1723 RSRHQFLM 1730
            ..|.:.||
Mouse  2214 SHRFRELM 2221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mute	NP_001097352.1	None
Gon4l	XP_036019277.1	PHA03247	<992..1258	CDD:223021	47/271 (17%)
		PAH	1672..1717	CDD:396992	12/47 (26%)
		PAH	<1772..1798	CDD:396992	6/25 (24%)
		CASP8AP2	2163..2228	CDD:213401	18/61 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KMH
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	215	1.000	Inparanoid score	I3613
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto92293
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16088
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4922
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	7.040