DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mute and gon4la

DIOPT Version :9

Sequence 1:	NP_001097352.1	Gene:	mute / 2768848	FlyBaseID:	FBgn0085444	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	XP_003200651.2	Gene:	gon4la / 560418	ZFINID:	ZDB-GENE-060503-728	Length:	1602	Species:	Danio rerio

Alignment Length:	1812	Identity:	355/1812 - (19%)
Similarity:	591/1812 - (32%)	Gaps:	635/1812 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RRPRKRKRVDR----QSLDSQVDEDA-------KEIDRRLRKVAKKNSISAEDMQKVVRKVVRND 72
            ||...|::.|.    ::..::|:::.       :|:||.|...::::::::.:::.::.:|:.|:
Zfish    95 RRKGLRRKKDAINEVEAQQNEVEDEIQPEVEIDRELDRELENKSRQHNLTSANVRSIIHEVITNE 159

  Fly    73 HVLALVTLKAEDELAREKLESAEQQKRGAIIITDTPSV--PKLTRAKARELNCTPGISLPQLN-- 133
            ||:|::                    :.||..|:...|  ||:||:|.:|: ...|:.:|..|
Zfish   160 HVVAMM--------------------KAAISETEPIPVFEPKMTRSKLKEV-VEKGVVIPTWNIS 203

  Fly   134 ------ETSTDNNGIEALIREDLHSDEEDEEYTFKEEDFHSDDDPNTTASDFDSNPCTPQTPLTA 192
                  |.......::..:.|:   |..||||...||:.....:.....||.:::..:|:.....
Zfish   204 PIKKPTEAKKGPQFVDIPLEEE---DSSDEEYRPDEEEEDETAEETLLESDLENSSSSPRVSRVQ 265

  Fly   193 NEESPIKFSDDGC----------------------------FKVPLDRNFQDK------------ 217
            ...|.   |:||.                            .:.|.:.:|.:|
Zfish   266 RSHSE---SEDGASRSRLNLCRSRHLTVAATPMGPPPPPDTSRAPPECSFLEKLHAVDEELAFGT 327

  Fly   218 --------------EDLRIATRTRSKFCLQQTTIEDLQSEFVPPDVEPSDVVENEMTANDADWMQ 268
                          |:..|:.|||||..|:...:..|::|...||:.| |:.|......|.:|.|
Zfish   328 DCMDSYQSLGGASGEESLISFRTRSKRPLRDVPLGRLEAELRAPDITP-DMYEFGSAPEDREWTQ 391

  Fly   269 FLND-FTKPLNNTVQGDDDDPINDPEY-VAADHLESEYENAEELRDVNISKKELTDLVSELFAGL 331
            :|.. ....::|..:|||:|   |||| ..||..|.:.|:....:.|.|:|||:.||:.|||...
Zfish   392 WLQGLMISDMDNDEEGDDED---DPEYNFLADIDEPDVEDYRNDKAVRITKKEVNDLMEELFDAF 453

  Fly   332 LEE--GVSLESIELETPQKFVESANVSMIPIDQ---VSRNIDFDGQQINANQQELSVFQPNLMPP 391
            .:|  |...|..|.|..::..||      |:.:   :..||.::....:..:|.....:..|
Zfish   454 QDELGGQDDEGHEEEEEKEEEES------PLQEPPGILENIQYEDPLADVLKQRYRTVREQL--- 509

  Fly   392 PCEGNEMGMGVPVPVAVLQEETGGSACNVVNIPSEALTVPPELIAVPIPGQPNCFQIAKVVGNDS 456
                          .||.:.:        ..:.|:.::|||   |.|                 .
Zfish   510 --------------AAVRKRK--------ALLESKGVSVPP---ACP-----------------Q 532

  Fly   457 TVGLPLTEETLQNFSSLHPMEPPVVAASNGDRYKKPFDTNFTWEYISVRKHIYSEYEEKFESLRN 521
            ....|:|..||
Zfish   533 RSSSPITSMTL------------------------------------------------------ 543

  Fly   522 VEPVNLNHLARSRGFTQSQHDMLQQQLRIHTQLLSQSYLQTYSHPTLYPMAKKPREMLEELHKMA 586
                           ..:|...||||::.|.|||:|..:.:.:...|...|...|:.|.||....
Zfish   544 ---------------NAAQRLQLQQQIQQHVQLLTQVNMLSSTVKGLETEASTSRQFLLELQMFG 593

  Fly   587 TKDPS-------------FNCWNLQEAVQLVRKWEHDLSSDEFKEENEKMMDFINKETDLTDGHT 638
            .:...             ||..|||.||.|:.:.:..|..|
Zfish   594 QRGEHNCGRAEHGFFTSIFNACNLQGAVSLLEELDQSLKGD------------------------ 634

  Fly   639 RQVPRLAPRIMD--------------LMLDSRVFMYPQYLPRMAFQPKLTQTTAYAPSEYQLIAI 689
                   |.::.              ||....||:||:.||.:..:|...: ..:..:|..|:.:
Zfish   635 -------PAVLSPCLPGCQFPASLAWLMATRSVFLYPELLPTIQLRPSKFK-GPFTSAEDCLVVL 691

  Fly   690 GLEKHLALMVKAKRQLRKGADPIRVACKRMIKDTICGKTARRIFLKI-AELRNSKQY---NPVKY 750
            | .||          ||....|:::.|:.::        |.|.|:.: :.:|::.|.   :.:|.
Zfish   692 G-HKH----------LRGTLHPLQMTCRYLL--------ATRSFISVKSHIRDACQKPFPSVIKT 737

  Fly   751 FF----------EHRRAPPANAILWGFAGGLVRTPRERHMELPSGWQ-------YYIEKTWDQKR 798
            :|          ..:|..|.:.          |.|.||...|...|.       |...:|::|
Zfish   738 YFMAGKCPSMPLASKRVSPCDQ----------RPPVEREQSLMPDWLSKNLKCIYKHVRTYNQ-- 790

  Fly   799 TRRNFKASKASSVASASYLEFVREAVGEDLLLPETFGQAAVPNGSAAGSEPPKESKPKKRPAQRR 863
            ...|.:.::|:..|...........:...|.|||...|..  ..||..:...|:.|..|.....:
Zfish   791 ASGNPQTTEATDPAGPGPHFCFPPGMRYPLSLPEDLAQTL--EASALSAFKKKKDKTDKSAKPLK 853

  Fly   864 PRPAENPPQLTIN----------------VNYVFGGNTS------AGNIPGV------------- 893
            |.|:....:|.:|                .|....||.:      ...:|.|
Zfish   854 PPPSAEKLELVLNQLPAILPKTLSLSRPQPNPCLPGNRAITGPFILSRVPPVGSKQARAIATSPN 918

  Fly   894 --------SGVSVPLVAGGNLAENVLNINRSLYTAAECSSLLALPPAPPPLDENAP--------- 941
                    |..|.|:   .|..|..:.|:.|   ||:...::.||.|..|..::.|
Zfish   919 ISTTFKPSSSTSAPV---KNAVETPMGISCS---AAQRDIIITLPAAVTPELKSYPSGHITVNQT 977

  Fly   942 ---------PA--------INFTVDKFTNTLQICELEESSKAVQ-------------PDLLP--- 973
                     ||        |:|...:..||. ||.....:..||             |.|||
Zfish   978 QIVTSNVVEPAVPRASNLIISFQPPQVANTF-ICPTPIINTNVQMPQNHISQRCGTLPKLLPKVS 1041

  Fly   974 ---AQDTPSVPGRNAKRARYQIFKPKVQSANKS----RKGSTPTRSRYHILR----ERLRHKLSQ 1027
               ||..|....|........:|      ||.|    |.|...|..:...|:    :.:|.:.||
Zfish  1042 GGLAQVCPKPVNRFVLLPSGNVF------ANSSFGHQRAGQEQTLKQSSALKCKHVKLMRQQTSQ 1100

  Fly  1028 -RCHSL---------------------------------------ITTYESYLRHHIEKY----- 1047
             ..||.                                       |...|...|..|:..
Zfish  1101 DSLHSADRLKGDQSQMSFIQETPNDGFEETAEAELNDDDDDDDGGIVENEEEERGKIDSIEMSLT 1165

  Fly  1048 --------------KDCEL-----------VQVVHNRFF------------ALELYTQLLVDLRM 1075
                          :|.|:           .|...||.|            .:.|..:|...:..
Zfish  1166 LSESSGSPMPSIDGEDAEMEMEKPEEQKEKEQEGCNRLFGDEETGGADNVSGVRLVPELQETMEK 1230

  Fly  1076 FCSNTNSKTAAQPKRSRSDDEAAKLRRANRQEEMLRQ-MLQPDTTEE---RNRKDAIFAMNFYEK 1136
            |. :..:||.:: |..||:.::......:...:..|: :|..|.::.   |:.||..||..:.||
Zfish  1231 FL-HLATKTVSE-KEGRSNIKSKHQPSGSYWTQTERKTVLHNDASDHDPYRDAKDIAFAQAYLEK 1293

  Fly  1137 VEEALLSA-NRLDDCKKFNSILQNFDPRQEKVSSLYLKVE-EILLPTHPELAEVFLNFLLPAEAA 1199
            |.|.|... .::|:   |..||.:|....|..:||.|.:. :.:|...|||.:.|..||.|.:|.
Zfish  1294 VYEVLHQVPGKVDE---FLCILSDFVKNPESHTSLQLLMRLKPILEDWPELLQDFAAFLHPDQAR 1355

  Fly  1200 EMGKFFEHFMICNATNFINKLNIYFSKQPAQIRKIYACLNELAEMPNVSMKKVENKIMPLLKGNQ 1264
            |.|...|......:..|:.:|...|.:|....||:...|..........:|:::.::..||:.:.
Zfish  1356 ECGLLAEQQAFERSRGFLRQLESTFGEQSYLYRKVVHILQGDQSQGLADLKEIKAEMALLLRDHT 1420

  Fly  1265 FLIDWFVQQFPQGKPPKRILSPVETINLHDVQNNTTGEYTETIQEFTDVPTPSKPGCHLKYINGR 1329
            .|::.|.:.|.|..|              .||.|.  |..:.::|    ..||:|        .|
Zfish  1421 DLLEEFWEYFKQIYP--------------QVQENV--ETNQVLEE----KQPSQP--------SR 1457

  Fly  1330 IFYGAKILLPAKLSF-----------MAASIYNEQSHDVPPVSSDSINCAHGIRAQGEKLLSMAS 1383
            .....|.|...|.|.           ||....|:..:....:..||      ..:.|:...|:.:
Zfish  1458 NMLADKKLETDKTSIKHRRKTNKHAQMAEMRRNKVKNSSAMLDKDS------EASLGDSQQSLFN 1516

  Fly  1384 NTDSDDGADRSEEDDASRALIIDTTSDEQNSCSSIEMCDETGLRA---HAIRLNPGLYTNSSFNN 1445
            .|.|...|.......|.:.:::.|...::   ..:..|.:.|.:.   |||
Zfish  1517 ATGSSVCAKNISHTSAGKKVVLWTREADR---VILTTCQQRGAKQTTFHAI-------------- 1564

  Fly  1446 AATSTPNLGNSHQSHHPHAKKTAINFGEISPRKQ---SAFNNSGLSPLSAAPNSSPQ 1499
                ...|||          |||   .|:|.|.|   ..|:.|  |.|...|::..|
Zfish  1565 ----AAQLGN----------KTA---SEVSERFQDLIKLFHKS--SKLHHTPDNWTQ 1602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mute	NP_001097352.1	None
gon4la	XP_003200651.2	PAH	1304..1349	CDD:280780	14/47 (30%)
		PAH	1387..1430	CDD:280780	8/42 (19%)
		CASP8AP2	1526..1590	CDD:213401	18/97 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	209	1.000	Inparanoid score	I3656
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D32744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26359
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16088
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4922
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.190