DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mute and gon4lb

DIOPT Version :9

Sequence 1:	NP_001097352.1	Gene:	mute / 2768848	FlyBaseID:	FBgn0085444	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	NP_001188464.1	Gene:	gon4lb / 555764	ZFINID:	ZDB-GENE-070117-2447	Length:	2055	Species:	Danio rerio

Alignment Length:	2240	Identity:	422/2240 - (18%)
Similarity:	673/2240 - (30%)	Gaps:	949/2240 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 NSSTPRRPRK-----RKRVDRQSLDSQVDEDAKEIDRRLRKVAKKNSISAEDMQKVVRKVVRNDH 73
            |.:....|:|     .|.:::.|.:.:.:|:.:::||.|...:||.::|:.:::.::.:||.|:|
Zfish   128 NQTEGEIPQKEDGDVEKTMEQLSEEDENEEELRKLDRDLTLKSKKLNLSSINVRNIIHEVVTNEH 192

  Fly    74 VLALVTLKAEDELAREKLESAEQQKRGAIIITDTPSV-PKLTRAKAREL----------NCTP-- 125
            |:|::           |....|.|        |.|.. ||:||:|.:|.          |.:|
Zfish   193 VVAMM-----------KAAIKETQ--------DMPMFEPKMTRSKLKEAVEKGVGMGNWNISPIK 238

  Fly   126 ---GISLPQL-------NETSTDNNGIEALIREDLHSDEEDE--EYTFKEEDFHSDDD------- 171
               .|..||.       .|.|:|    |....::   |||||  |.||.|.|..|...
Zfish   239 KANDIKPPQFVDIPLQEEEDSSD----EEYCPDE---DEEDETAEETFLESDVESTSSSPRGIRR 296

  Fly   172 -PNTTASDFDSNPCTPQ---------------------TPLTANEESPIKFSDDGCFKV-PLDRN 213
             |:.|....|....:|:                     .|.:......:|..|....|: .:|:.
Zfish   297 FPSQTPPHCDDASNSPRLKPRLARHLRVEAVPMGPPAPPPQSCGLSRSLKTLDPFIEKLHAVDKE 361

  Fly   214 FQ------------------DKEDLRIATRTRSKFCLQQTTIEDLQSEFVPPDVEPSDVVENEMT 260
            .:                  :.:|..:|.|||||..|:...::.|::|...||:.| |:.:|..|
Zfish   362 LELSPLCMEPYQALSSGGAGEPDDSLVACRTRSKRPLRDVPLDQLEAELRAPDITP-DMYDNVST 425

  Fly   261 ANDADWMQFLND-FTKPLNNTVQGDDDDPINDPEYVAADHL-ESEYENAEELRDVNISKKELTDL 323
            ..|.:|.|:|.. .|..|:|..:.|:||   ||||...|.| |.:.|:....|.|.|:|||:.:|
Zfish   426 PEDREWTQWLQGLMTSHLDNDEEADEDD---DPEYNFLDDLDEPDLEDYRNDRAVRITKKEVNEL 487

  Fly   324 VSELFAGLLEEGVSLESIE--LETPQKFVESANVSMIPIDQVSRNIDFD--------------GQ 372
            :.|||....:|..:.|..:  .:..::..|.||.:  |...|.:.|.|:              .:
Zfish   488 MEELFETFHDELAANEPDDEGHDEDEEREEEANDT--PQFNVPQAIRFEEPLAHMLTACRRTVRE 550

  Fly   373 QINANQQELSVFQPNLMPPPCEGNEMGMGVPVPVAVLQEETGGSACNVVNIPSEALTVPPELIAV 437
            |::|.||.             ..|:        |...|..:|                 |.::.|
Zfish   551 QLDALQQR-------------RENQ--------VRTTQHASG-----------------PGMVFV 577

  Fly   438 PIPGQPNCFQIAKVVGNDSTVGLPLTEETLQNFSSLHPMEPPVVAASNGDRYKKPFDTNFTWEYI 502
                ||:|                                 |:|.
Zfish   578 ----QPSC---------------------------------PLVV-------------------- 585

  Fly   503 SVRKHIYSEYEEKFESLRNVEPVNLNHLARSRGFTQSQHDMLQQQLRIHTQLLSQSYLQTYSHPT 567
                                              |.:|...||||::.|.|||:|..:.......
Zfish   586 ----------------------------------TPAQRIQLQQQIQQHVQLLTQVSMLCDPVGA 616

  Fly   568 LYPMAKKPREMLEELHKMATKDPS------------FNCWNLQEAVQLVRKWEHDLSSDEFKEEN 620
            |...|:..:..|.||...|.:...            |...||..::.|:              |.
Zfish   617 LQTEAQTTKHFLGELLSFAERAEEERSAVNLGFKSVFRVCNLLSSINLL--------------EE 667

  Fly   621 EKMMDFINKETDLTDGH--TRQVPRLAPRIMDLMLDSRVFMYPQYLPRMAFQPKLTQTTA---YA 680
            .|....::......:.|  ....|.|...:..|.....||:||:.||..:..|.|..:.:   |:
Zfish   668 VKQSPSLSCLPPKPNRHHSVHSYPLLPAGLAWLFATRSVFLYPELLPHCSLDPALHPSRSKHYYS 732

  Fly   681 PSEYQLIAIGLEKHLA-----------LMVKAKRQLRKGADPIRVACKRMIKDTICGKTARRIFL 734
            ..|..|:.:|| ||.|           .:::.|||     :.:|:..|.|:
Zfish   733 KGEDGLLVLGL-KHFAQTEFPYQLISRYLIRPKRQ-----EQLRMRVKDMV-------------- 777

  Fly   735 KIAELRNSKQY--NPVKYFFEHRRAPPANAILWGFAGGLVRTPRERHMELPSGWQY----YIEKT 793
                   |.:|  |.:||:.::...||...:......|..|.|.||..|:...|..    .|:|:
Zfish   778 -------SPKYPHNIIKYYCQNHVVPPLPVVCKPVVHGEERPPVEREQEVMPNWLKKSLPLIQKS 835

  Fly   794 WDQKRTRRNFKASKASSVASASYLEFVREAVGEDLLLPETFGQAAVPNGSAAGSEPPKESKPKKR 858
            ..|.      ..:..|:..||| |.|.:| ......||:.......|  |...|.|   |:||.|
Zfish   836 ICQS------DLTMTSTTKSAS-LPFPKE-TRYPQFLPKGLSLRLHP--SQVASRP---SQPKSR 887

  Fly   859 -----------PAQRRPRPAENPPQLTINVNYVFGGNTSAGNIPGVSGV-------------SVP 899
                       |..:.|........|..|::........|.:.| ::||             :||
Zfish   888 ILRAFTNRTLAPLAKAPSCPTGTGHLLTNISTPVLLLAQAPSTP-INGVFPLVHPSLTPAHGTVP 951

  Fly   900 L--------------VAGGNLAENVLNINRSLYTAAECS-------------------------- 924
            |              :...|.|....|:..|:....:|.
Zfish   952 LNASYPINFHYLSPELGASNPAHLPANLPPSVVQKPQCDVPLLSTGTVKTHGVQQQTSDKHKKRT 1016

  Fly   925 ---SLLALPPAPP-----PLDEN-----APPAI--------NFTVDKFTNTLQICELEESSK--- 965
               .|..|.|||.     ||...     :.|.|        |...:..::.:.:.:..|:..
Zfish  1017 MPRKLAPLRPAPQLPRLLPLSSGSIGNISNPGIIIDQQISLNVPHNLQSDNVIVIKAHENVNTHR 1081

  Fly   966 ---AVQPDL-----------------LP------------AQDTPSV--PGRNAKRARYQIFKPK 996
               ::.|||                 ||            |:|.|||  .|.|.:|.   :|.|:
Zfish  1082 TVPSLSPDLVVQLVPQTQVAENTTSSLPRKTTPRSDVSQTAKDIPSVQSSGENGQRT---VFSPQ 1143

  Fly   997 --------------VQSANK----------------SRKGSTPTRSRYHILRERLRH-------- 1023
                          ||:.:.                ::..|.|:......|.::..|
Zfish  1144 TAAPAAVDSSQFVLVQTVSPTGPPQFLLLPQDSLVLNQPASLPSEGTLQNLSQQTSHLDISTTST 1208

  Fly  1024 --KLSQR------------------------------------------------------C--- 1029
              |.|::                                                      |
Zfish  1209 ALKNSEKTEVHLNNPTTSLPVSREEDGERQEVDEEMVGDRWEEEMASALFGSPLLALSESSCSPD 1273

  Fly  1030 ---------------------------HSLITTYESYLRH-HI---------------------- 1044
                                       ||...|.|:...| |.
Zfish  1274 SSPDASMDSGSDAMVRVEMEDGELPSVHSASATQETPDVHKHSSGDEKEQQSSGGEKQNSGNEEG 1338

  Fly  1045 -------------------EKYKDC---------------------------------------- 1050
                               ||.:|.
Zfish  1339 RAEESESRKDEAQDEDKGGEKNEDGEGDGKRDEGGSGDKGREEKDGDGEKDGDGERDEEEEDFDD 1403

  Fly  1051 ----------------ELVQVVHNRFFALELYTQLLVDLRMFC-----SNTNSKTA--------- 1085
                            |.|..|......:|..|.|..:.|: |     ...||.|:
Zfish  1404 LTQDEDEEEVMSSASEESVLSVPELQETMEKLTWLASERRL-CREGDSEEDNSPTSPTSPTSPNS 1467

  Fly  1086 --------AQPKRSRSDDEAA-------------------------------------------- 1098
                    :|.:.|..:|:.|
Zfish  1468 QNSPASQNSQEENSEDEDDGAMKGDELEAGEGEGEKLPEGDAPAGDDPPQISEKVGGRGRGRGRP 1532

  Fly  1099 ---KLRRANRQEE---------MLRQMLQPDTTEERNRKDAIFAMNFYEKVEEALLSANRLDDCK 1151
               .|:|..|||.         :|......|....|..||..:|..:..:|.|||....  ...:
Zfish  1533 PPRSLKRGRRQERGSKDASKLLLLYDDHILDNDPMRESKDMAYAQAYLNRVREALQDVP--GKVE 1595

  Fly  1152 KFNSILQNFDPRQE--KVSSLYLKVEEILLPTHPELAEVFLNFLLPAEAAEMGKFFEHFMICNAT 1214
            :|..:|..||...|  .|..|:.:::: ||...|||.:.|..||||.:|.|.|.|.|......:.
Zfish  1596 EFLGLLYEFDQAGESHSVIELFAQLKQ-LLKDWPELLKDFAAFLLPEQALECGLFEEQQAFERSR 1659

  Fly  1215 NFINKLNIYFSKQPAQIRKIYACLNELAEMPNVSMKKVENKIMPLLKGNQFLIDWFVQQFPQGKP 1279
            .|:.:|.|.|.:.|:..:||...|...:.:....:::::.::..||||:..|...|...|.:.:|
Zfish  1660 RFLRQLEISFGENPSHYQKIVRALQSGSPLSPAGIEELKTQMATLLKGHTHLQGEFWMFFDEMRP 1724

  Fly  1280 PKRILSPV------ETINLHDVQNNTTGEYTETIQEFTDVPTPSKPGCHLKYINGRIFYG-AKIL 1337
            |     |.      |.:...||...|.||        ..|...|:         |.::.| .::.
Zfish  1725 P-----PARPGQFEEAVWPEDVATGTDGE--------AGVSVTSR---------GGVWGGFEEVT 1767

  Fly  1338 LPAKLSFMAASIYNEQSHDVPPVSS--------------------------DSIN---------- 1366
            ||....       :|:||.:..:||                          ||::
Zfish  1768 LPDLDE-------DEESHKIRQISSRSKRRKELHTYKDCDWPEKDCSCSCHDSVHDAKHRRHKRK 1825

  Fly  1367 ----CAHGIRAQGEKLL----SMASNTD--SDDGADRSEEDDASRALIIDTTSDEQNSCSSIEMC 1421
                |.....|.|.|:|    |..|:.|  |:.|.:..||:   |.|..|..:::       |:.
Zfish  1826 GCLRCQSNKAANGSKVLKGRDSAFSSADAQSERGGEEKEEE---RVLGEDGEAEK-------ELK 1880

  Fly  1422 DETGLRAHAIRLNPGLYTNSSFNN-----------AATSTPNLGNSHQSHHPHAKKTAINFGEIS 1475
            ||||..|           ||..::           |.:|.|...|:|  :....:||.......|
Zfish  1881 DETGSGA-----------NSPHHDGEGSVWEREERATSSIPEEQNTH--NQDDEEKTEEKNHHAS 1932

  Fly  1476 PRKQS-------------AFNNSGLSPLSAAP------NSSPQVDKRKSPTKKIRSPLNQTQSRQ 1521
            |.|.|             |...|.|||...||      :.:|..::....|::....:..|..:|
Zfish  1933 PEKHSRDEEDSAESGQTEAAQQSSLSPALDAPVCAKNISLTPTGERVILWTREADRVILTTCQQQ 1997

  Fly  1522 RANNQPMVVIHESQPSSSPAIECAKRLRTLIDQESVRDAADTKAGIRIIAQAKQQPPNQCSSEAI 1586
            .|:......:.| |..:..|.|.::|.|.|               :|:.    ....:|.|||
Zfish  1998 GASQSTFQAVSE-QLGNKTASEVSRRFRDL---------------MRLF----HTSASQASSE-- 2040

  Fly  1587 TKVEVVSLDESAENMPFCTNLKMDTDQSEE 1616
                    ||:||.       :..||:.::
Zfish  2041 --------DEAAEQ-------QSATDEEQD 2055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mute	NP_001097352.1	None
gon4lb	NP_001188464.1	PAH	1593..1638	CDD:280780	13/45 (29%)
		PAH	<1693..1719	CDD:280780	6/25 (24%)
		CASP8AP2	1969..2033	CDD:213401	13/83 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581653
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	209	1.000	Inparanoid score	I3656
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D32744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26359
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16088
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4922
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	8.080