DRSC/TRiP Functional Genomics Resources

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Protein Alignment mute and GON4L

DIOPT Version :9

Sequence 1:NP_001097352.1 Gene:mute / 2768848 FlyBaseID:FBgn0085444 Length:1739 Species:Drosophila melanogaster
Sequence 2:NP_001269785.1 Gene:GON4L / 54856 HGNCID:25973 Length:2241 Species:Homo sapiens


Alignment Length:2287 Identity:443/2287 - (19%)
Similarity:732/2287 - (32%) Gaps:888/2287 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 KSNSSTPRRPRKRKRVDRQ----------SLDSQVDEDAKEIDRRLRKVAKKNSISAEDMQKVVR 66
            :.|..:.:|.:|:|...|:          :.|.::|:   .:||.|...||:::::|.:::.::.
Human   235 QDNEESEKRRKKKKGTKRKRDGRGQEGTLAYDLKLDD---MLDRTLEDGAKQHNLTAVNVRNILH 296

  Fly    67 KVVRNDHVLALVTLKAEDELAREKLESAEQQKRGAIIIT-DTPSV-PKLTRAKARELNCTPGISL 129
            :|:.|:||:|::                    :.||..| |.|.. ||:||:|.:|: ...|:.:
Human   297 EVITNEHVVAMM--------------------KAAISETEDMPMFEPKMTRSKLKEV-VEKGVVI 340

  Fly   130 PQLNETSTDN-NGIEALIREDLHSDEE---DEEYTFKEEDFHSDDDPNTTASDFDSNPCTPQ--- 187
            |..|.:.... |.|:.....|:|.:|:   ||||...:|:.....:.:...||.:|...:|:   
Human   341 PTWNISPIKKANEIKPPQFVDIHLEEDDSSDEEYQPDDEEEDETAEESLLESDVESTASSPRGAK 405

  Fly   188 -------TPLT-ANEESPI------------------------------KFSDDGCFKVPLDR-- 212
                   :.:| .:|||.|                              |.:.|..|...|..  
Human   406 KSRLRQSSEMTETDEESGILSEAEKVTTPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVD 470

  Fly   213 -----------NFQDKEDLRIATRTRSKFCLQQTTIEDLQSEFVPPDVEPSDVVENEMTANDADW 266
                       :||..:|..||.|||||..|:...:..|::|...||:.|.....|  ||:|.||
Human   471 EELASSPVCMDSFQPMDDSLIAFRTRSKMPLKDVPLGQLEAELQAPDITPDMYDPN--TADDEDW 533

  Fly   267 MQFL----NDFTKPLNNTVQGDDDDPINDPEYVAADHL-ESEYENAEELRDVNISKKELTDLVSE 326
            ..:|    ||   .:.|..:.||||   ||||...:.| |.:.|:....|.|.|:|||:.:|:.|
Human   534 KMWLGGLMND---DVGNEDEADDDD---DPEYNFLEDLDEPDTEDFRTDRAVRITKKEVNELMEE 592

  Fly   327 LFAGLLEEGVSLESIELETPQKFVESANVSMIPIDQVSRNIDFDGQQINANQQELSVFQPNLMPP 391
            ||               ||                                      ||      
Human   593 LF---------------ET--------------------------------------FQ------ 598

  Fly   392 PCEGNEMGMGVPVPVAVLQEETGGSACNVVNIPSEALTVPPELIAVPIPGQPNCFQIAKVVGNDS 456
                :|||..       ..|:.|         |.|     .|.:|.|.|                
Human   599 ----DEMGFS-------NMEDDG---------PEE-----EECVAEPRP---------------- 622

  Fly   457 TVGLPLTEETLQNFSSLHPMEPPVVAASNGDRYKKPFDTNFTWEYISVRKHIYSEYEEKFES--- 518
                        ||::...:           |:::|. .|...|.....|.::.:.:.|..|   
Human   623 ------------NFNTPQAL-----------RFEEPL-ANLLNEQHRTVKELFEQLKMKKSSAKQ 663

  Fly   519 LRNVEPVNLNHLARSRGFTQ------SQHDMLQQQLRIHTQLLSQSYLQTYSHPTLYPMAKKPRE 577
            |:.||.|.    .:|....|      :|...||||::.|.|||:|.:|....:|.|.|.|...|.
Human   664 LQEVEKVK----PQSEKVHQTLILDPAQRKRLQQQMQQHVQLLTQIHLLATCNPNLNPEATTTRI 724

  Fly   578 MLEELHKMATK--------DPSFN-----CWNLQEAVQLVRKWEHDLSSDEFKEENEKMMDFINK 629
            .|:||...|..        :|.|.     | ||..|:||:..:...:|.|....:..|..     
Human   725 FLKELGTFAQSSIALHHQYNPKFQTLFQPC-NLMGAMQLIEDFSTHVSIDCSPHKTVKKT----- 783

  Fly   630 ETDLTDGHTRQVPRLAPRIMDLMLDSRVFMYPQYLPRMAFQPKLTQ-TTAYAPSEYQLIAIGLEK 693
                    ..:.|.|..::..::..|:|||||:.||..:.:.|..| ...:..:|..|:|:|| |
Human   784 --------ANEFPCLPKQVAWILATSKVFMYPELLPVCSLKAKNPQDKIVFTKAEDNLLALGL-K 839

  Fly   694 HLALMVKAKRQLRKGAD-PIRVACKRMIKDTICGKTARRIFLKIAELR-NSKQYNPVKYFFE--- 753
            |.           :|.: |..:..|.::   .| |||.::.::|..|. |....|.:|::.:   
Human   840 HF-----------EGTEFPNPLISKYLL---TC-KTAHQLTVRIKNLNMNRAPDNIIKFYKKTKQ 889

  Fly   754 -------------HRRAPP----ANAILWGFAGGLVRTPRE-RHM-------------------- 780
                         |:..||    .:.:.:.....|.....| |||                    
Human   890 LPVLGKCCEEIQPHQWKPPIEREEHRLPFWLKASLPSIQEELRHMADGAREVGNMTGTTEINSDR 954

  Fly   781 -------ELPSGWQY------------------YIEKTWDQKRT--------------RRNFKAS 806
                   ||.|..:|                  :..|.|.|||:              :.:|...
Human   955 SLEKDNLELGSESRYPLLLPKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQPSPSLQPSFNPG 1019

  Fly   807 KASS-------------------VASASYLEFV----------REAVGEDLLLPET--------- 833
            |..:                   :..|:.|:.|          .|:......||..         
Human  1020 KTPARSTHSEAPPSKMVLRIPHPIQPATVLQTVPGVPPLGVSGGESFESPAALPAVPPEARTSFP 1084

  Fly   834 -------FGQAAVPNGSAAGSEPPKESKP--KKRPAQRR---------PRPA-ENP-------PQ 872
                   ...|.||........|.|..||  ::||::||         |.|. .:|       |.
Human  1085 LSESQTLLSSAPVPKVMLPSLAPSKFRKPYVRRRPSKRRGVKASPCMKPAPVIHHPASVIFTVPA 1149

  Fly   873 LTINVNYVFGG-------NTSAGNIPG-----------------------VSGVSVPLVAGGN-- 905
            .|:.:..:.||       |.:....|.                       .|.|| ||:..||  
Human  1150 TTVKIVSLGGGCNMIQPVNAAVAQSPQTIPITTLLVNPTSFPCPLNQSLVASSVS-PLIVSGNSV 1213

  Fly   906 ------LAENVLNINRSLYTAA-----------------ECSSLLAL-------PPAPP------ 934
                  ..|:..::|..:..|.                 |.|.|.|.       .|.||      
Human  1214 NLPIPSTPEDKAHVNVDIACAVADGENAFQGLEPKLEPQELSPLSATVFPKVEHSPGPPLADAEC 1278

  Fly   935 --PLDENAPPAINFTVDKFTNTLQICELEESSKAVQPDLLP-----AQDTPSVPG-------RNA 985
              .|.||:  |..:||.|         .||..:|::|  ||     :.:.|: ||       ...
Human  1279 QEGLSENS--ACRWTVVK---------TEEGRQALEP--LPQGIQESLNNPT-PGDLEEIVKMEP 1329

  Fly   986 KRARYQIF-KP--------KVQSANKSRKG--STPTRSRYHILRERLRHKLSQRCH--------- 1030
            :.||.:|. .|        ||:.|.:...|  |....|...:.::.:..|..:|..         
Human  1330 EEAREEISGSPERDICDDIKVEHAVELDTGAPSEELSSAGEVTKQTVLQKEEERSQPTKTPSSSQ 1394

  Fly  1031 ------------------SLITTYESYLR------------------------------------ 1041
                              :.:::.:..:|                                    
Human  1395 EPPDEGTSGTDVNKGSSKNALSSMDPEVRLSSPPGKPEDSSSVDGQSVGTPVGPETGGEKNGPEE 1459

  Fly  1042 HHIEKYKDC-------------ELVQVVHNRFFALELYTQLLVDLRMFCSNTNSKTAAQPKRS-- 1091
            ...|.:.|.             |.|..|......:|..|.|..:.||.....:.:..:|.:.|  
Human  1460 EEEEDFDDLTQDEEDEMSSASEESVLSVPELQETMEKLTWLASERRMSQEGESEEENSQEENSEP 1524

  Fly  1092 --RSDDEAAKLRRANRQEEMLRQML-----------QPDTTEE---------------------- 1121
              ..::||..:....:::||..:.:           .|:|..|                      
Human  1525 EEEEEEEAEGMESLQKEDEMTDEAVGDSAEKPPTFASPETAPEVETSRTPPGESIKAAGKGRNNH 1589

  Fly  1122 ---------------------------------RNRKDAIFAMNFYEKVEEALLS-ANRLDDCKK 1152
                                             |.:||..||..:..:|.|||.. ..:.:|   
Human  1590 RARNKRGSRARASKDTSKLLLLYDEDILERDPLREQKDLAFAQAYLTRVREALQHIPGKYED--- 1651

  Fly  1153 FNSILQNFDPRQEKVSSLYL-KVEEILLPTHPELAEVFLNFLLPAEAAEMGKFFEHFMICNATNF 1216
            |..::..|:...::.:::.| |..:|||...|:|.:.|..||||.:|...|.|.|......:..|
Human  1652 FLQVIYEFESSTQRRTAVDLYKSLQILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKF 1716

  Fly  1217 INKLNIYFSKQPAQIRKIYACLNELAEMPNVSMKKVENKIMPLLKGNQFLIDWFVQQFPQGKPPK 1281
            :.:|.|.|::.|:..:||...|...|:.....:.:::.::..||||:..|.|.|...|...:|..
Human  1717 LRQLEICFAENPSHHQKIIKVLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAA 1781

  Fly  1282 RILSPVETINLHDVQNNTTGEYTETIQEFTDVPTPSKPGCHLKYINGRIFYGAKILLPAKLSFMA 1346
            ..:...|.|       |.|.|.......|.:|..|..                            
Human  1782 SRMGDFEEI-------NWTEEKEYEFDGFEEVALPDV---------------------------- 1811

  Fly  1347 ASIYNEQSHDVPPVSSDSINCAHGIRAQGEKLLSMASN---TDSDDGAD----RSEEDDASRALI 1404
                 |:..:.|.:.:.|.|       :.:|.:.:.::   |:..|||.    ...|......| 
Human  1812 -----EEEEEPPKIPTASKN-------KRKKEIGVQNHDKETEWPDGAKDCACSCHEGGPDSKL- 1863

  Fly  1405 IDTTSDEQNSCS--SIEMCDETGLRAHAIRLNPGLYTNSSFNNAATSTPNLGNSHQSHHPHAKKT 1467
               ...::.|||  |.::||                               ..|::|..||    
Human  1864 ---KKSKRRSCSHCSSKVCD-------------------------------SKSYKSKEPH---- 1890

  Fly  1468 AINFGEI---SPRKQSAFNNSGLSPLSAAPNSSPQVDKRKSPTKKIRSPLNQTQSR----QRANN 1525
                 |:   ||.:::       ||:..|..:....|..:....:.|.....||||    .|...
Human  1891 -----ELVGSSPHREA-------SPMPGAKEAGQGKDMMEEEAPEERESTEATQSRTVRTTRKGE 1943

  Fly  1526 QPM---VVIHESQPSSSPAIECAKRLRTLID------QESVRDAADTKAGIRIIAQAKQQPPNQC 1581
            .|:   :.:..:.||..   |.....|.|:|      .|:.:....|.|.:..:.:.:..|..:.
Human  1944 MPVSAGLAVGSTLPSPR---EVTVTERLLLDGPPPHSPETPQFPPTTGAVLYTVKRNQVGPEVRS 2005

  Fly  1582 SSEAITKVE-------VVSLDESAENMPFCTNLKMDTDQSEEE------------LEPLQLSAGN 1627
            ..:|..:::       .||..|:         |.:..|.||.|            |.|:.....:
Human  2006 CPKASPRLQKEREGQKAVSESEA---------LMLVWDASETEKLPGTVEPPASFLSPVSSKTRD 2061

  Fly  1628 TPQHVITTQFDSDE----DCKLDVVATLANCTTTE-----DRSESAAALPATTSHSESGSSHSAP 1683
            ..:..::.:.|:.|    ..:..|......|...|     |.||::...|......:||:....|
Human  2062 AGRRHVSGKPDTQERWLPSSRARVKTRDRTCPVHESPSGIDTSETSPKAPRGGLAKDSGTQAKGP 2126

  Fly  1684 -----------------------------WTREEDKVIL-IEMKIGARDREQLIRRMRAKLKNRS 1718
                                         ||||.|:||| :..:.||  :.|....:..:|.|::
Human  2127 EGEQQPKAAEATVCANNSKVSSTGEKVVLWTREADRVILTMCQEQGA--QPQTFNIISQQLGNKT 2189

  Fly  1719 IEELRSRHQFLM 1730
            ..|:..|.:.||
Human  2190 PAEVSHRFRELM 2201

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
muteNP_001097352.1 None
GON4LNP_001269785.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 122..259 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 366..460 16/93 (17%)
Required for interaction with YY1, SIN3A AND HDAC1, and transcriptional repression activity. /evidence=ECO:0000250|UniProtKB:Q9DB00 600..1339 169/848 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1008..1031 2/22 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1111..1131 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1301..1320 6/21 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1356..1601 25/244 (10%)
PAH 1648..1693 CDD:280780 11/47 (23%)
PAH <1749..1774 CDD:280780 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1809..1960 38/241 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2002..2025 2/22 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2149 15/109 (14%)
CASP8AP2 2143..2208 CDD:213401 17/61 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2208..2241
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_28KMH
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 210 1.000 Inparanoid score I3679
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D32744at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - oto88725
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR16088
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4922
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
88.050

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