DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33459 and F10

DIOPT Version :9

Sequence 1:	NP_995855.2	Gene:	CG33459 / 2768847	FlyBaseID:	FBgn0053459	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	255	Identity:	72/255 - (28%)
Similarity:	114/255 - (44%)	Gaps:	39/255 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 RIFGGMDAGLVSTPWMAFLHN-HLQFLCGGSLITSEFVLTAAHCVMPTPKNLTVRLGEYDWTRQM 100
            ||.||.:......||.|.|.| ..:..|||::::..::||||||:... |...||:|:.: |.|.
Human   234 RIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQA-KRFKVRVGDRN-TEQE 296

  Fly   101 DSINPKHRHREYMVTRIYTHPSYRSIAAYDIALLKLNQTVEYTVAIRPICLVLPENFHEWYWLVD 165
            :.....|.....:....:|..:|    .:|||:|:|...:.:.:.:.|.|  |||  .:|
Human   297 EGGEAVHEVEVVIKHNRFTKETY----DFDIAVLRLKTPITFRMNVAPAC--LPE--RDW----- 348

  Fly   166 SVEDFTLT-------GWGATKTE-PVSQVLQSANLTQIDRGTCHDRYGHSVDHTHICAG--SSKS 220
             .|...:|       |:|.|..: ..|..|:...:..:||.:|.......:.....|||  :.:.
Human   349 -AESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQE 412

  Fly   221 FACVGDSGSPLAMKVVHNRRY--IHAQVGIVSRGPKNC---DGVTVFTNVVSFTEWIFRT 275
            .||.||||.|      |..|:  .:...||||.| :.|   ....::|.|.:|.:||.|:
Human   413 DACQGDSGGP------HVTRFKDTYFVTGIVSWG-EGCARKGKYGIYTKVTAFLKWIDRS 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33459	NP_995855.2	Tryp_SPc	37..272	CDD:214473	69/250 (28%)
CG33459	NP_995855.2	Tryp_SPc	38..272	CDD:238113	68/249 (27%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011
		FXa_inhibition	129..164	CDD:317114
		O-glycosylated at one site	183..203
		Tryp_SPc	235..464	CDD:238113	70/251 (28%)
		O-glycosylated at one site	476..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24278
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010