DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33458 and PRSS56

DIOPT Version :9

Sequence 1:	NP_995854.2	Gene:	CG33458 / 2768846	FlyBaseID:	FBgn0053458	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_001356777.1	Gene:	PRSS56 / 646960	HGNCID:	39433	Length:	604	Species:	Homo sapiens

Alignment Length:	268	Identity:	77/268 - (28%)
Similarity:	117/268 - (43%)	Gaps:	48/268 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 CG--------ISKYTYRITGGRDSPLMLNPWLAYLHINSKFICGGSLLNHWFVLTAAHCFRDKNA 85
            ||        :::...||.||..:|....|||..|.:..:.:|||.|:...:||||||||.....
Human    88 CGERRPSTANVTRAHGRIVGGSAAPPGAWPWLVRLQLGGQPLCGGVLVAASWVLTAAHCFVGAPN 152

  Fly    86 KVL--VRLGENDASQKIDCNESECAAPHLEYMIMQKLIHPLY--RTAHYYDIALAKLNRYVVYTD 146
            ::|  |.|.|....::.:           |..:.:.|.||.:  ||.| .|:||.:|...|....
Human   153 ELLWTVTLAEGSRGEQAE-----------EVPVNRILPHPKFDPRTFH-NDLALVQLWTPVSPGG 205

  Fly   147 SIRPICLMLNPNWQVYVDTIRYFIITGWGAT-NASEVSDKLQLTRIPQIDRFTCRYWFG-YMVDR 209
            |.||:||...|. :....|.  ..|.||||. .....::.::..|:|.:...|||...| .:...
Human   206 SARPVCLPQEPQ-EPPAGTA--CAIAGWGALFEDGPEAEAVREARVPLLSTDTCRRALGPGLRPS 267

  Fly   210 THICAGESKHYVG-----KGDSGGPLGSMVDYKYAKRFFQFGIVS------HLRQPFHGVSVFTN 263
            |.:|||   :..|     :||||||| :..:.....|...||:.|      ...:|    .|:|.
Human   268 TMLCAG---YLAGGVDSCQGDSGGPL-TCSEPGPRPREVLFGVTSWGDGCGEPGKP----GVYTR 324

  Fly   264 ILSYSNWI 271
            :..:.:|:
Human   325 VAVFKDWL 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33458	NP_995854.2	Tryp_SPc	37..271	CDD:214473	74/250 (30%)
CG33458	NP_995854.2	Tryp_SPc	38..274	CDD:238113	74/251 (29%)
PRSS56	NP_001356777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..96		2/7 (29%)
		Tryp_SPc	105..335	CDD:238113	74/251 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..475
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158880
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24278
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940