DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33458 and PROC

DIOPT Version :9

Sequence 1:	NP_995854.2	Gene:	CG33458 / 2768846	FlyBaseID:	FBgn0053458	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	XP_024308770.1	Gene:	PROC / 5624	HGNCID:	9451	Length:	576	Species:	Homo sapiens

Alignment Length:	258	Identity:	78/258 - (30%)
Similarity:	114/258 - (44%)	Gaps:	57/258 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 NPW-LAYLHINSKFICGGSLLNHWFVLTAAHCFRDKNAKVLVRLGENDAS--QKIDCNESECAAP 110
            :|| :..|....|..||..|::..:|||||||. |::.|:||||||.|..  :|.:
Human   338 SPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCM-DESKKLLVRLGEYDLRRWEKWE--------- 392

  Fly   111 HLEYMIMQKLIHPLY-RTAHYYDIALAKLNRYVVYTDSIRPICL--------MLNPNWQVYVDTI 166
             |:..|.:..:||.| ::....||||..|.:....:.:|.||||        .||   |...:|
Human   393 -LDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELN---QAGQET- 452

  Fly   167 RYFIITGWGATNASEVSDK------LQLTRIPQIDRFTCRYWFGYMVDRTHICAG--ESKHYVGK 223
               ::||||..::.|...|      |...:||.:....|......||....:|||  ..:....:
Human   453 ---LVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACE 514

  Fly   224 GDSGGPLGSMVDYKYAKRFFQFGIVS-----HLRQPFHGVSVFTNILSYSNWIHRTIITNSGH 281
            ||||||:.:    .:...:|..|:||     .|   .|...|:|.:..|.:|||       ||
Human   515 GDSGGPMVA----SFHGTWFLVGLVSWGEGCGL---LHNYGVYTKVSRYLDWIH-------GH 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33458	NP_995854.2	Tryp_SPc	37..271	CDD:214473	73/246 (30%)
CG33458	NP_995854.2	Tryp_SPc	38..274	CDD:238113	76/249 (31%)
PROC	XP_024308770.1	GLA	117..168	CDD:214503
		EGF_CA	182..213	CDD:238011
		FXa_inhibition	255..290	CDD:317114
		Tryp_SPc	328..563	CDD:238113	76/256 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24278
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010