Protein Alignment CG33458 and KLK1

DIOPT Version :10

• Sequence 1: NP_995854.2
• Gene: CG33458 / 2768846
• FlyBaseID: FBgn0053458
• Length: 281
• Species: Drosophila melanogaster
• Sequence 2: NP_002248.1
• Gene: KLK1 / 3816
• HGNCID: 6357
• Length: 262
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 75/269 - (27%)
• Similarity: 106/269 - (39%)
• Gaps: 56/269 - (20%)

  Fly    37 RITGGRDSPLMLNPWLAYLHINSKFICGGSLLNHWFVLTAAHCFRDKNAKVLVR---LGENDASQ 98
            ||.||.:......||.|.|:..|.|.|||.|::..:|||||||..|.....|.|   ..:.:.:|
Human    24 RIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQ 88

  Fly    99 KIDCNESECAAPHLEYMIMQKLIHPLYRTAHY-YDIALAKLNRYV-VYTDSIRPICLMLNPNWQV 161
            .:..:||   .||..:.:.....|.......| :|:.|.:|.... ..||:::.:.|   |..:.
Human    89 FVHVSES---FPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVEL---PTEEP 147

  Fly   162 YVDTIRYFIITGWGATNASEVS--DKLQLTRIPQIDRFTCRYWFGYMVDRTHICAGESKHYVG-- 222
            .|.:.  .:.:|||:......|  |.||...:..:....|:......|....:|.|   |..|
Human   148 EVGST--CLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVG---HLEGGK 207

  Fly   223 ---KGDSGGPLGSMVDYKYAKRFFQFGIVSHLRQPFHGV--------------SVFTNILSYSNW 270
               .|||||||  |.|          |::       .||              ||...:|||..|
Human   208 DTCVGDSGGPL--MCD----------GVL-------QGVTSWGYVPCGTPNKPSVAVRVLSYVKW 253

  Fly   271 IHRTIITNS 279
            |..||..||
Human   254 IEDTIAENS 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33458	NP_995854.2	Tryp_SPc	38..274	CDD:238113	70/261 (27%)
KLK1	NP_002248.1	Tryp_SPc	25..257	CDD:238113	70/261 (27%)