DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33458 and F10

DIOPT Version :9

Sequence 1:	NP_995854.2	Gene:	CG33458 / 2768846	FlyBaseID:	FBgn0053458	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	253	Identity:	72/253 - (28%)
Similarity:	132/253 - (52%)	Gaps:	30/253 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 RITGGRDSPLMLNPWLAYLHIN--SKFICGGSLLNHWFVLTAAHC-FRDKNAKVLVRLGENDASQ 98
            ||.||::......||.|.| ||  ::..|||::|:.:::|||||| ::.|..|  ||:|:.:..|
Human   234 RIVGGQECKDGECPWQALL-INEENEGFCGGTILSEFYILTAAHCLYQAKRFK--VRVGDRNTEQ 295

  Fly    99 KIDCNESECAAPHLEYMIMQKLIHPLYRTAHY-YDIALAKLNRYVVYTDSIRPICLMLNPNW-QV 161
            :    |...|...:|.:|.    |..:....| :|||:.:|...:.:..::.|.||. ..:| :.
Human   296 E----EGGEAVHEVEVVIK----HNRFTKETYDFDIAVLRLKTPITFRMNVAPACLP-ERDWAES 351

  Fly   162 YVDTIRYFIITGWGATN-ASEVSDKLQLTRIPQIDRFTCRYWFGYMVDRTHICAG--ESKHYVGK 223
            .:.|.:..|::|:|.|: ....|.:|::..:|.:||.:|:....:::.:...|||  ..:....:
Human   352 TLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQ 416

  Fly   224 GDSGGPLGSMVDYKYAKRFFQFGIVSH----LRQPFHGVSVFTNILSYSNWIHRTIIT 277
            ||||||..:    ::...:|..||||.    .|:..:|  ::|.:.::..||.|::.|
Human   417 GDSGGPHVT----RFKDTYFVTGIVSWGEGCARKGKYG--IYTKVTAFLKWIDRSMKT 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33458	NP_995854.2	Tryp_SPc	37..271	CDD:214473	68/245 (28%)
CG33458	NP_995854.2	Tryp_SPc	38..274	CDD:238113	69/247 (28%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011
		FXa_inhibition	129..164	CDD:317114
		O-glycosylated at one site	183..203
		Tryp_SPc	235..464	CDD:238113	69/246 (28%)
		O-glycosylated at one site	476..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24278
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010