DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33462 and Tmprss6

DIOPT Version :9

Sequence 1:	NP_995844.2	Gene:	CG33462 / 2768841	FlyBaseID:	FBgn0053462	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	261	Identity:	74/261 - (28%)
Similarity:	116/261 - (44%)	Gaps:	32/261 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DCGIPHNISERSVNAKLAQN---PWMAYLETPKGFH-CSGTLINHLFVLTAAHCVPDD-----LL 83
            |||: ...|.|.|...::..   ||.|.|:. :|.| |.|.||...:|:|||||..:|     .|
  Rat   567 DCGL-QGPSSRIVGGAMSSEGEWPWQASLQI-RGRHICGGALIADRWVITAAHCFQEDSMASPRL 629

  Fly    84 ITVRLGEYNTKTKVDCDNHLCQEPFQEYNVDMGFRHRYYNANDQTNDIGMLRLGRRVEYLNHIRP 148
            .||.||:....::...:        ..:.|...|.|.|:..:....|:.:|:|...|.|...:||
  Rat   630 WTVFLGKMRQNSRWPGE--------VSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVRP 686

  Fly   149 ICIFASNRFQEPIDQLTWFTTTVW-RETAANATSKVLRTMNIDRQPKETCSEIYGWNMTFEQICA 212
            :|:.|.:.|.|| .|..|.|.  | .:......|..|:.:::...|::.|:|.|.:.:|...:||
  Rat   687 VCLPARSHFFEP-GQHCWITG--WGAQREGGPGSSTLQKVDVQLIPQDLCNEAYRYQVTPRMLCA 748

  Fly   213 G--NTLSQLCSTDSGAPQIRKMWHNGSDRYVQLGIASRVKGQCQNS---GILMDLLSYADWIKRV 272
            |  ......|..|||.|.:.|   ..|.|:...|:.|...| |...   |:...:....:||::|
  Rat   749 GYRKGKKDACQGDSGGPLVCK---EPSGRWFLAGLVSWGLG-CGRPNFFGVYTRVTRVVNWIQQV 809

  Fly   273 V 273
            :
  Rat   810 L 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33462	NP_995844.2	Tryp_SPc	48..272	CDD:238113	67/235 (29%)
CG33462	NP_995844.2	Tryp_SPc	48..269	CDD:214473	65/232 (28%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060
		Ldl_recept_a	529..566	CDD:278486
		Tryp_SPc	576..806	CDD:214473	67/245 (27%)
		Tryp_SPc	577..809	CDD:238113	68/247 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910