DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33462 and F2

DIOPT Version :9

Sequence 1:	NP_995844.2	Gene:	CG33462 / 2768841	FlyBaseID:	FBgn0053462	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_075213.2	Gene:	F2 / 29251	RGDID:	61996	Length:	617	Species:	Rattus norvegicus

Alignment Length:	320	Identity:	77/320 - (24%)
Similarity:	130/320 - (40%)	Gaps:	88/320 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EEDCGIPHNISERSVNAKLAQN---------------------PW--MAYLETPKGFHCSGTLIN 67
            |.|||:.....::|:..|..:.                     ||  |.:.::|:...|..:||:
  Rat   329 EADCGLRPLFEKKSLTDKTEKELLDSYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLIS 393

  Fly    68 HLFVLTAAHCV----------PDDLLITVRLGEYNTKTKVDCDNHLCQEPFQEYNV------DMG 116
            ..:|||||||:          .:|||  ||:|:: ::|:            .|.||      :..
  Rat   394 DRWVLTAAHCILYPPWDKNFTENDLL--VRIGKH-SRTR------------YERNVEKISMLEKI 443

  Fly   117 FRHRYYNANDQTN-DIGMLRLGRRVEYLNHIRPICIFASNRFQEPIDQLTWFTTTVW---RETAA 177
            :.|..||..:..: ||.:|:|.:.|.:.::|.|:|:.........:........|.|   |||..
  Rat   444 YIHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLQAGYKGRVTGWGNLRETWT 508

  Fly   178 NATSK----VLRTMNIDRQPKETCSEIYGWNMTFEQICAGNTLS-----QLCSTDSGAPQIRKMW 233
            ...::    ||:.:|:....:..|.......:|....|||..::     ..|..|||.|.:.|..
  Rat   509 TNINEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDACEGDSGGPFVMKSP 573

  Fly   234 HNGSDRYVQLGIASRVKGQCQNSGILMDLLSYADWIKRVVRQYGPSTDMNRSLKKWVDKI 293
            :|  .|:.|:||.|..:| |..:|                 :||..|.:.| ||:|:.|:
  Rat   574 YN--HRWYQMGIVSWGEG-CDRNG-----------------KYGFYTHVFR-LKRWMQKV 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33462	NP_995844.2	Tryp_SPc	48..272	CDD:238113	63/254 (25%)
CG33462	NP_995844.2	Tryp_SPc	48..269	CDD:214473	63/251 (25%)
F2	NP_075213.2	GLA	25..89	CDD:214503
		KR	107..189	CDD:214527
		Kringle	215..292	CDD:278480
		Thrombin_light	312..359	CDD:286482	6/29 (21%)
		Tryp_SPc	359..608	CDD:214473	69/284 (24%)
		Tryp_SPc	360..612	CDD:238113	70/287 (24%)
		High affinity receptor-binding region which is also known as the TP508 peptide	547..569		7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910