DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fs and TMEFF1

DIOPT Version :9

Sequence 1:	NP_652376.2	Gene:	Fs / 2768836	FlyBaseID:	FBgn0259878	Length:	767	Species:	Drosophila melanogaster
Sequence 2:	NP_003683.2	Gene:	TMEFF1 / 8577	HGNCID:	11866	Length:	380	Species:	Homo sapiens

Alignment Length:	218	Identity:	55/218 - (25%)
Similarity:	84/218 - (38%)	Gaps:	60/218 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   572 GTDGRTYN-TECQLRK---RACRTNNAQLEVAYRGHCKNSCSGVHCLNGLTCVEDQYLMPHCIAC 632
            |..|::.| :|..:|:   |.|..::.:    |.|.||....|:.|                 ||
Human    56 GGKGKSINCSELNVRESDVRVCDESSCK----YGGVCKEDGDGLKC-----------------AC 99

  Fly   633 RIECPWDNLDVDSSGYDERQAVCGVDGKTYRSACDINRMICKIGRSIAVAYPGPCRAG------- 690
            :.:|..:.:           .|||.:|.||::.|.:.|..||..:.|.|...|||.:.
Human   100 QFQCHTNYI-----------PVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGE 153

  Fly   691 ---RVSCADI-----KCGP---KDNCLVDLQTRQPRCVTCRYKCPRKQQRPVHKICGYNNQTYNS 744
               ..|.|::     ||||   |..|  |.......|| |...|......||   |..:..:||:
Human   154 GEEEGSGAEVHRKHSKCGPCKYKAEC--DEDAENVGCV-CNIDCSGYSFNPV---CASDGSSYNN 212

  Fly   745 WCEMHKHSCESRYFIGVKSQGSC 767
            .|.:.:.||..:..|.::..|.|
Human   213 PCFVREASCIKQEQIDIRHLGHC 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs	NP_652376.2	KAZAL	564..604	CDD:197624	9/35 (26%)
		KAZAL_FS	654..687	CDD:238052	13/32 (41%)
		KAZAL_FS	723..767	CDD:238052	11/43 (26%)
TMEFF1	NP_003683.2	KAZAL	99..143	CDD:197624	15/54 (28%)
		KAZAL	189..235	CDD:197624	13/49 (27%)
		PHA02887	<275..311	CDD:333467
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810