DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs and RECK

DIOPT Version :9

Sequence 1:	NP_652376.2	Gene:	Fs / 2768836	FlyBaseID:	FBgn0259878	Length:	767	Species:	Drosophila melanogaster
Sequence 2:	NP_066934.1	Gene:	RECK / 8434	HGNCID:	11345	Length:	971	Species:	Homo sapiens

Alignment Length:	664	Identity:	127/664 - (19%)
Similarity:	193/664 - (29%)	Gaps:	263/664 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 THLGSGK--CGQVFSTDISRSECC-------GSSQSFSYTDR--ELSSVEYFFATAIGGGVECSP 270
            |.|...|  |....:|...|..|.       |::||:...||  |.:.||....|.:....|  |
Human   283 TGLDGAKLHCCSKANTSTCRELCTKLYSMSWGNTQSWQEFDRFCEYNPVEVSMLTCLADVRE--P 345

  Fly   271 CMESCKGFKCGPNKKCVKRKGRPKCVCAPECGAALRRRTHQQELELEQEPELEEEQQEMKPPR-- 333
            |...|:..     ..|.....||                    .||.:....:.:|..|...:
Human   346 CQLGCRNL-----TYCTNFNNRP--------------------TELFRSCNAQSDQGAMNDMKLW 385

  Fly   334 ESRSLSSENTNFNLGLDGGQRQRADNQRKLQPRESKHRRLLIIDSSSRSSSNLPDQPTSGRRGRV 398
            |..|:.....|..: ||         .:|.||...|           ..:.:|..:|.
Human   386 EKGSIKMPFINIPV-LD---------IKKCQPEMWK-----------AIACSLQIKPC------- 422

  Fly   399 EMTGYERRRHRNNHGKHLTRS------MTTGANDSFPADKTPAQ-----SPA--------ADSIL 444
                     |..:.|..:.:|      ...|..:.||.|.|...     ||.        .|:.|
Human   423 ---------HSKSRGSIICKSDCVEILKKCGDQNKFPEDHTAESICELLSPTDDLKNCIPLDTYL 478

  Fly   445 AQSRLANL-------ANANE-PAN---DINRQ----------------------SSTRVRHQHAR 476
            ..|.|.|:       .|.|. |||   ::||:                      |...||.....
Human   479 RPSTLGNIVEEVTHPCNPNPCPANELCEVNRKGCPSGDPCLPYFCVQGCKLGEASDFIVRQGTLI 543

  Fly   477 RIEHAPNP----------DNGLRK---RQH-----------KQQQQHQHQHQDRMNTEAQSANTT 517
            ::..:...          .:||.:   ..|           .:::.|........|..:..|...
Human   544 QVPSSAGEVGCYKICSCGQSGLLENCMEMHCIDLQKSCIVGGKRKSHGTSFSIDCNVCSCFAGNL 608

  Fly   518 VSGSGSGATNHRRISQLQHGSETAASSDLANTHDLAHLGGIYAPLPPQHSN---PVCGTDGRTYN 579
            |..:        |:...:|.||     |...|         :..||...::   ||||.:||||.
Human   609 VCST--------RLCLSEHSSE-----DDRRT---------FTGLPCNCADQFVPVCGQNGRTYP 651

  Fly   580 TECQLRKRACRTNNAQLEVAYRGHC--KNSCSGVHCLNGLTCVE--------------DQYLMPH 628
            :.|  ..|.....:.|.|.   |.|  |:.|:...|.....|:.              .||   .
Human   652 SAC--IARCVGLQDHQFEF---GSCMSKDPCNPNPCQKNQRCIPKPQVCLTTFDKFGCSQY---E 708

  Fly   629 CIACRIECPWDNLDVDSSGYDERQ-AVCGVDGKTYRSACDINRMICKIGRSIAVAYPGPCRAGRV 692
            |:..::.|            |:.| .||..|...:.:.|.:.:      |..:::|.|||
Human   709 CVPRQLAC------------DQVQDPVCDTDHMEHNNLCTLYQ------RGKSLSYKGPC----- 750

  Fly   693 SCADIKCGPKDNCLVDLQTRQPRCVTCRYKCPRKQQRPVHKICGYNNQTYNSWCEMHKHSCESRY 757
                                ||.|            |....:||:|.:||:|.|..:.......|
Human   751 --------------------QPFC------------RATEPVCGHNGETYSSVCAAYSDRVAVDY 783

  Fly   758 F-----IGVKSQGS 766
            :     :||.|:.|
Human   784 YGDCQAVGVLSEHS 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs	NP_652376.2	KAZAL	564..604	CDD:197624	13/42 (31%)
		KAZAL_FS	654..687	CDD:238052	7/32 (22%)
		KAZAL_FS	723..767	CDD:238052	13/49 (27%)
RECK	NP_066934.1	OATP	<633..>658	CDD:281175	9/26 (35%)
RECK	NP_066934.1	Amnionless	<802..>886	CDD:291494
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900