DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fs and SPARC

DIOPT Version :9

Sequence 1:	NP_652376.2	Gene:	Fs / 2768836	FlyBaseID:	FBgn0259878	Length:	767	Species:	Drosophila melanogaster
Sequence 2:	NP_001296373.1	Gene:	SPARC / 6678	HGNCID:	11219	Length:	341	Species:	Homo sapiens

Alignment Length:	243	Identity:	52/243 - (21%)
Similarity:	78/243 - (32%)	Gaps:	90/243 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   605 KNSCSGVHCLNGLTCVEDQYLMPHCIACR--IECPWDNLDVDSSGYDERQAVCGVDGKTYRSACD 667
            :|.|...||.:|..|..|:...|.|: |:  ..||        :...|.:.||..|.||:.|:|.
Human    69 ENPCQNHHCKHGKVCELDENNTPMCV-CQDPTSCP--------APIGEFEKVCSNDNKTFDSSCH 124

  Fly   668 INRMIC-----KIGRSIAVAYPGPCRAGRVSCADIKCGP-----KD---NCLVDLQTRQP--RCV 717
            .....|     |.|..:.:.|.|||:. ...|.|.:...     :|   |.||.|..|..  ..:
Human   125 FFATKCTLEGTKKGHKLHLDYIGPCKY-IPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLL 188

  Fly   718 TCRYKCPRKQ-----------QRPVHKICGYNNQTYNSWC--------EMHKH------------ 751
            |.:.|...|:           ..||..:.....:.||.:.        ::.:|
Human   189 TEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELA 253

  Fly   752 ----------SCESRYF-------------------IGVKS---QGSC 767
                      .|.:|:|                   .|:|.   ||||
Human   254 PLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQRYRQGSC 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs	NP_652376.2	KAZAL	564..604	CDD:197624
		KAZAL_FS	654..687	CDD:238052	12/37 (32%)
		KAZAL_FS	723..767	CDD:238052	13/106 (12%)
SPARC	NP_001296373.1	FSL_SPARC	71..152	CDD:238649	26/90 (29%)
		SPARC_Ca_bdg	153..287	CDD:287550	19/133 (14%)
		SPARC_EC	154..290	CDD:238155	19/135 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4004
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900