DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fs and Spink5

DIOPT Version :9

Sequence 1:	NP_652376.2	Gene:	Fs / 2768836	FlyBaseID:	FBgn0259878	Length:	767	Species:	Drosophila melanogaster
Sequence 2:	NP_001164077.1	Gene:	Spink5 / 361319	RGDID:	1306540	Length:	1019	Species:	Rattus norvegicus

Alignment Length:	451	Identity:	97/451 - (21%)
Similarity:	153/451 - (33%)	Gaps:	137/451 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 GGG-----VECSPCMESCKG--FKCGPNKKCVK-RKGRP---KCVCAPECGAALRRRTHQQELEL 316
            |||     .||:...||.|.  ..|......|: ..|:|   |||.   |...|||
  Rat   627 GGGNQKAKDECAQYWESMKNGELSCTRESDPVRGADGKPYNNKCVM---CKELLRR--------- 679

  Fly   317 EQEPELEEEQQEMKPPRESRSLSSENTNFNLGLDGGQRQRADNQRKLQPRESKHRRLLIIDSSSR 381
                |:||:.:.    ..|||..:|.          ::...|..|    .:.|:.:||....|..
  Rat   680 ----EMEEKNKN----SASRSNGTET----------RKDVCDQFR----NQMKNGKLLCTRESDP 722

  Fly   382 SSSNLPDQPTSGR-----RGRVEMTGYERRRHRNNHGKHLTRSMTTGANDSFPADKTPAQSPAAD 441
            :..  ||..|.|.     :.|:|....|:::..:...::      ||||.|...|    |.....
  Rat   723 TRG--PDGKTHGNKCAMCKERLEREAAEKKKKEDEDKRN------TGANKSNKKD----QCHEFR 775

  Fly   442 SILAQSRLANLANANEP------ANDINRQSSTRVRHQHARRIEHAPNPDNGLRKRQHKQQQQHQ 500
            |:....||. ....|:|      ...:|:.:..::..:|          :...||.:|::
  Rat   776 SMQLNGRLI-CTRENDPIRGPDGKTHVNKCAMCQMMFEH----------EASERKMRHEE----- 824

  Fly   501 HQHQDRMNTEAQSANTTVSGSGSGATNHRRISQLQHGSET-----AASSDLANTHDLAHLGGIYA 560
                   |:.:||.|......|......:.:...|..|..     .:..:.:|..:|...|.:
  Rat   825 -------NSRSQSTNEAEDNCGEVHNTAQDVKPRQARSSLPSIRGISEDECSNFQNLISNGKL-- 880

  Fly   561 PLPPQHSNPVCGTDGRTYNTECQ-----LRKRACRTNNAQLEVAYRGHCK--------NSCSGVH 612
             :.|:..:|:.|.||..|..:|.     |.|:|...:..|.:.:.....|        :|.....
  Rat   881 -ICPEMDDPLHGADGSFYQNKCNMCRDVLEKKALERSGFQEKSSQIRSTKEDGPEFSSSSLDSHM 944

  Fly   613 CLNGLTCVEDQYLMPHCIACRIECPWDNLDVDSSGYDERQAVCGVDGKTYRSACDINRMIC 673
            |.|........||          || .||:          .|||.||:||.:.|    |:|
  Rat   945 CKNYRILPRVGYL----------CP-KNLN----------PVCGDDGQTYANPC----MLC 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs	NP_652376.2	KAZAL	564..604	CDD:197624	11/44 (25%)
		KAZAL_FS	654..687	CDD:238052	10/20 (50%)
		KAZAL_FS	723..767	CDD:238052
Spink5	NP_001164077.1	KAZAL_PSTI	109..153	CDD:238648
		Kazal_2	177..>209	CDD:284958
		KAZAL	241..278	CDD:197624
		Kazal_2	314..348	CDD:284958
		Kazal_2	383..418	CDD:284958
		Kazal_2	442..476	CDD:284958
		KAZAL	576..616	CDD:197624
		KAZAL_FS	651..>675	CDD:294071	8/26 (31%)
		KAZAL	716..>741	CDD:197624	5/26 (19%)
		KAZAL	784..821	CDD:197624	6/47 (13%)
		KAZAL_PSTI	954..998	CDD:238648	16/52 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900