DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs and F29G6.1

DIOPT Version :9

Sequence 1:	NP_652376.2	Gene:	Fs / 2768836	FlyBaseID:	FBgn0259878	Length:	767	Species:	Drosophila melanogaster
Sequence 2:	NP_509920.3	Gene:	F29G6.1 / 181339	WormBaseID:	WBGene00009257	Length:	1189	Species:	Caenorhabditis elegans

Alignment Length:	832	Identity:	155/832 - (18%)
Similarity:	259/832 - (31%)	Gaps:	229/832 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 QLAATMSKTSAATATQL--ARATSRECRTILGLFIVSAWSALQELANCLRQDEDRYVGHGRDVNA 120
            |....|.|:...:.|:|  .|.:|::|.                 .||...:.|...    |.|.
Worm   108 QFQCIMKKSMGLSLTKLHMGRCSSKDCN-----------------HNCTNTEFDPVC----DTNG 151

  Fly   121 S---------------SDASDEVSMA---------REQQQHQRQHSKHSASSSPAKSMRCTRAKA 161
            |               ...|..:.:|         ||.|:.:....:...|.:....:..|.|..
Worm   152 SVYRNLCVFQMRRCELQLESQRIQLAEDRKFCLRSRETQRFKLAGVESYTSYADEPYLETTEAST 216

  Fly   162 ASASTGTAAATAT-------------LGAAAAEGATSGHQLGGQPLMALLIGLLLLNFRLAAAGT 213
            .:....|.|:|..             :....|:.:.|.|:....||
Worm   217 VAPDLTTTASTTIPMKSEKPSRNETFINKVIAKTSASKHRENHSPL------------------- 262

  Fly   214 CWQTHLGSGKCGQVFSTDISRSECCGSSQSFSYTDRELSSVEYFFA--TAIGGGV-------ECS 269
               |.....:...:...|.|....|.:.   :.|.:.:...::|..  ..|.|.|       .|.
Worm   263 ---TRNDLNRACSIKECDKSWDPVCDTR---NRTHKNVCQFKFFACKINKIDGSVIDIAHSGACR 321

  Fly   270 PCMESCKGFKCGPNKK----CVKRKGRPKCVCA---PECGAALRRRTHQQELEL-------EQEP 320
            ....:|  ..|..::|    |..|......:|:   ..|.|   |....:|..|       |:.|
Worm   322 ARKSTC--ITCPKDEKKIPICDNRNMTHPTLCSFIQYNCEA---RNNEDEERVLVHIKSCHERSP 381

  Fly   321 E--LEEEQQEMKPPRESRSLSSENTNFNLGLDGGQRQRADNQRKLQPRESKHRRLLIIDSSSRSS 383
            :  |::|.......|:.:.:..|..|.:..|...|:... |.|||..| |.:.|.|.....:|..
Worm   382 QFTLKDEICPRTCSRDVKPVCDEANNTHQNLCHFQQYNC-NMRKLGIR-SPYLRYLRPCVKNRKI 444

  Fly   384 SNLPDQPTSGRRGRVEMTGYERRRHRN---NHGKHLTRSMTT----------------GANDSFP 429
            .|..:        .|||    |....|   ...|.:..|.||                .|.:...
Worm   445 DNAVE--------NVEM----RATVSNVVIKTSKSVAESTTTSQLKQTVASEKTTFIVSAFEKVL 497

  Fly   430 ADKTPAQSPAADSILAQSRLANLANANEPANDINRQSSTRVRHQHARRIEHA------PN-PDNG 487
            ...|...||::..:....::..:..:..|  |...:|...:..:....::.|      || |.:|
Worm   498 KSTTSTPSPSSTIVTTTIKVPTVTFSTLP--DPTTKSILEIEIETTTPLDVAFFDCPKPNCPTDG 560

  Fly   488 LRKRQHKQQQQHQHQHQDRMNTEAQSANTTVSGSGSGATNHRRISQLQHGSETAASSDLANTHDL 552
                        |.......|........|.|...:.:..|:.....:....:..:..:..|.|
Worm   561 ------------QPVCDSAGNLHGNLCEFTYSRCIAASKGHQIHIATEENCISKEACQMPCTDD- 612

  Fly   553 AHLGGIYAPLPPQHSNPVCGTDGRTYNTECQLRKRACRTNNAQLEVAYRGHCKNSCSGVHCL--- 614
                          .:|:|.:|..||...||.||:.|.  :::|||.::|.| :.|....|.
Worm   613 --------------KHPICASDFSTYENLCQFRKQKCL--DSELEVLFKGKC-SECLDSPCALPA 660

  Fly   615 -----NGLTCVEDQ-------YLMPHCIACR------------IECPWDNLDVDSSGYDERQAVC 655
                 ....|:|||       |.|..||..|            :.||    .|:|...::...||
Worm   661 ENSPDESFVCLEDQSTKSLCEYQMLSCIFERGYGVNLTVQYIGVCCP----PVESCDTEKPDPVC 721

  Fly   656 GVDGKTYRSACDINRMICKIGR----SIAVAYPGPCRAGRVSCADIKCGPKDNCLVDLQTRQPRC 716
            ...|.|:.:.|::|...||:.:    .:.|...|.|....::  |.....::....:::.::...
Worm   722 TDSGATFLTECELNIENCKLKKLDQPKLVVVSQGICEKDMLT--DDFSSNRNFQKPNIEFKRENT 784

  Fly   717 VTCRYKCPRKQQRPVHKICGYNNQTYNSWCEMHKHSCES-RYFIGVKSQGSC 767
            ..|..:|.....    .:||.|..|:.:.|.:.|..||| ...|.|...|.|
Worm   785 FNCSMECDNSYD----PLCGTNGVTFTNACSLQKEICESANSTIEVAYTGMC 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs	NP_652376.2	KAZAL	564..604	CDD:197624	14/39 (36%)
		KAZAL_FS	654..687	CDD:238052	10/36 (28%)
		KAZAL_FS	723..767	CDD:238052	13/44 (30%)
F29G6.1	NP_509920.3	KAZAL_FS	40..79	CDD:238052
		KAZAL_FS	133..>168	CDD:294071	7/55 (13%)
		KAZAL	274..320	CDD:197624	8/48 (17%)
		KAZAL	389..>424	CDD:197624	6/35 (17%)
		KAZAL	550..599	CDD:197624	9/60 (15%)
		KAZAL	605..648	CDD:197624	16/59 (27%)
		KAZAL	786..832	CDD:197624	14/49 (29%)
		KAZAL	833..881	CDD:197624	155/832 (19%)
		KAZAL	886..937	CDD:197624
		KAZAL	941..988	CDD:197624
		KAZAL	1092..1138	CDD:197624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I8264
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5159
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840