DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs and Fstl3

DIOPT Version :9

Sequence 1:	NP_652376.2	Gene:	Fs / 2768836	FlyBaseID:	FBgn0259878	Length:	767	Species:	Drosophila melanogaster
Sequence 2:	NP_446081.1	Gene:	Fstl3 / 114031	RGDID:	621811	Length:	256	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	88/489 - (17%)
Similarity:	116/489 - (23%)	Gaps:	288/489 - (58%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 GTCWQTHLGSGK---CGQVFSTDISRSECCGSS------QSFSYTDRELSSVEYFFATAIGGGVE 267
            |.||   |..||   |..|..|.:||.|||.|.      .:|::...::|.:.:.      |.|.
  Rat    34 GVCW---LQQGKEATCSLVLKTQVSREECCASGNINTAWSNFTHPGNKISLLGFL------GLVH 89

  Fly   268 CSPCMESCKGFKCGPNKKCVKRKGRPKCVCAPECGAALRRRTHQQELELEQEPELEEEQQEMKPP 332
            |.||.:||.|.:|||.|.|....|||.|.|...|
  Rat    90 CLPCKDSCDGVECGPGKACRMLGGRPHCECVSNC------------------------------- 123

  Fly   333 RESRSLSSENTNFNLGLDGGQRQRADNQRKLQPRESKHRRLLIIDSSSRSSSNLPDQPTSGRRGR 397

  Rat   124 ----------------------------------------------------------------- 123

  Fly   398 VEMTGYERRRHRNNHGKHLTRSMTTGANDSFPADKTPAQSPAADSILAQSRLANLANANEPANDI 462
                                        :..||
  Rat   124 ----------------------------EGVPA-------------------------------- 128

  Fly   463 NRQSSTRVRHQHARRIEHAPNPDNGLRKRQHKQQQQHQHQHQDRMNTEAQSANTTVSGSGSGATN 527
                                    |.:
  Rat   129 ------------------------GFQ-------------------------------------- 131

  Fly   528 HRRISQLQHGSETAASSDLANTHDLAHLGGIYAPLPPQHSNPVCGTDGRTYNTECQLRKRACRTN 592
                                                      |||:||.||..||:||...|| .
  Rat   132 ------------------------------------------VCGSDGATYRDECELRTARCR-G 153

  Fly   593 NAQLEVAYRGHCKNSCSGVHCLNGLTCVEDQYLMPHCIACR-IECPWDNLDVDSSGYDERQAVCG 656
            :..|.|.|||.|:.||:.|.|....:|:.||....||:.|| ..||...        :..|.:||
  Rat   154 HPDLRVMYRGRCQKSCAQVVCPRPQSCLVDQTGSAHCVVCRAAPCPVPP--------NPGQELCG 210

  Fly   657 VDGKTYRSACDINRMICKIGRSIAVAYPGPCRAG 690
            .:..||.|:|.:.:..|.:||||.|.:||.|..|
  Rat   211 NNNVTYISSCHLRQATCFLGRSIGVRHPGICTGG 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs	NP_652376.2	KAZAL	564..604	CDD:197624	18/39 (46%)
		KAZAL_FS	654..687	CDD:238052	14/32 (44%)
		KAZAL_FS	723..767	CDD:238052
Fstl3	NP_446081.1	KAZAL	118..165	CDD:197624	23/307 (7%)
Fstl3	NP_446081.1	KAZAL_FS	198..241	CDD:238052	17/50 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11678
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4105
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1460520at2759
OrthoFinder	1	1.000	-	-		FOG0003390
OrthoInspector	1	1.000	-	-		otm46427
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2287
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.830