Protein Alignment ppk25 and asic1a

DIOPT Version :10

• Sequence 1: NP_995766.1
• Gene: ppk25 / 2768722
• FlyBaseID: FBgn0053349
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: NP_999955.1
• Gene: asic1a / 791696
• ZFINID: ZDB-GENE-040513-2
• Length: 501
• Species: Danio rerio
• Alignment Length: 497
• Identity: 104/497 - (20%)
• Similarity: 188/497 - (37%)
• Gaps: 104/497 - (20%)

  Fly    10 QPDWLAELCQESSIHGMPYIARRDLHWAERLFWTFIILGSAYYAISSCLNQWYRFRDNPIVYEY- 73
            ||..|......|::||:.:|...:...|:...|....|.|..:.:..|:::...:.:.|.|.:.
Zfish    19 QPPPLQVFAHTSTLHGISHIFSYEKITAKCCLWVVFFLSSLTFLMYVCIDRIQFYLEYPHVTKLD 83

  Fly    74 EYLFGLRIFPFVGITLC-------------PRYHDETEIPRLINQTWGVDPSEDKEKAVYYRKFL 125
            |....:.:||  .:|:|             ..|| ..|:..|:|....|..:...|::|
Zfish    84 EITTPVMVFP--AVTICNLNSIRFSRITRNDLYH-AGELLALLNSRHEVREAHLVEESV------ 139

  Fly   126 LAINGLRYST-LETLEP-------FENDTTLDNVNYLNILLTLQKKVIAVKIPPELAPIITEVGL 182
              :..|:..| ..:.:|       |.|.|..|   ..::||:.|.:....: |.:.:.:.|..|.
Zfish   140 --MEVLKSKTDFRSFKPRHFNMWEFYNRTGHD---IKDMLLSCQFRGSPCR-PEDFSVVFTRYGK 198

  Fly   183 CQTSSQLNRYGNPYGKLE------TQDMEPMKQCGYLSNCITSLKPI------NSIVAPIFMYLH 235
            |.|.:. ...|.|...::      .:.|..::|..||        |:      :|..|.|.:.:|
Zfish   199 CYTFNS-GETGPPRVSVKGGMGNGLEIMLDIQQDEYL--------PVWGESDESSFEAGIKVQIH 254

  Fly   236 DVEEMMLPDDMR---TPSFDAKDIESKDLDIMLHTTSAESEVRNLPVAYRKCRFSDENNLQYYSP 297
            ..:|....|.:.   .|.|..            ..:..|..:..||..:..|: |...:..|:..
Zfish   255 SQDEPPFIDQLGFGVAPGFQT------------FVSCQEQRLVYLPAPWGSCK-STPPSSDYFRA 306

  Fly   298 YHPSLCRLECRIKWALSLCNCKPYFYVAAP-EVPICT----------VSGMLCLARSKW--LERP 349
            |..|.||.:|..::.:..|||:   .|..| :.|.||          ....|....|.:  .|.|
Zfish   307 YSISACRTDCETRYLVENCNCR---MVHMPGDAPYCTPVLYKECAHPALDFLVETDSDYCSCETP 368

  Fly   350 CDCYPSCREETFTIFKVSDQTGGD---DNYS-GERF--ERTLIINLQISRMG---INRRVVFSTD 405
            |:.....:|.:|.  |:..:....   ..|| .|::  |..:::::....:.   |.:|..:...
Zfish   369 CNITRYSKELSFV--KIPSKASVKYLAKKYSKSEKYITENVMVLDVFFEALNYETIEQRKAYEVA 431

  Fly   406 QLIMSFGGAIGLFLGASFMTI---YGVVYFFLTFIAYTCKNR 444
            .|:...||.:|||:|||.:||   :..:|..:.:....|.|:
Zfish   432 GLLGDIGGQMGLFIGASILTILELFDYLYEVMKYRLCRCSNK 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk25	NP_995766.1	ASC	18..432	CDD:459966	98/475 (21%)
asic1a	NP_999955.1	ENaC	23..469	CDD:273304	100/487 (21%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:Q1XA76	446..448		1/1 (100%)