Protein Alignment ppk25 and SCNN1G

DIOPT Version :9

• Sequence 1: NP_995766.1
• Gene: ppk25 / 2768722
• FlyBaseID: FBgn0053349
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: NP_001030.2
• Gene: SCNN1G / 6340
• HGNCID: 10602
• Length: 649
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 115/594 - (19%)
• Similarity: 201/594 - (33%)
• Gaps: 199/594 - (33%)

  Fly     8 PKQPDWLAEL----CQESSIHGMPYIA-----RRDLHW-------AERLFWTFIILGSAYYAISS 56
            |:.|. :.||    |..::.||...|.     .|.|.|       ...:.|...:|..::|.:|.
Human    20 PQAPT-IKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQCALLVFSFYTVSV 83

  Fly    57 CLNQWYRFRDNPIV-------YEY---------------EYLFGLRIFP------------FVGI 87
            .:...:|..|.|.|       |:|               |.|..|..||            .|..
Human    84 SIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAESWNSVSE 148

  Fly    88 TLCPRYHDETEIPRLINQTWGVDPSEDKEKAVYYRKFLL-------------AINGLRYSTLETL 139
            ...||:  ...||.||..      .::|.||   |.|..             |.|.:...:.:.:
Human   149 GKQPRF--SHRIPLLIFD------QDEKGKA---RDFFTGRKRKVGGSIIHKASNVMHIESKQVV 202

  Fly   140 --EPFENDTTLD-----------------NVNYLNIL--LTLQKKVIAVKIPPELAPIIT----- 178
              :...|||: |                 .::|:||:  :.|:||:.......||  ::|
Human   203 GFQLCSNDTS-DCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEEL--LVTCFFDG 264

  Fly   179 --------------EVGLCQTSSQLNRY----------GNPYG-----KLETQDMEPMKQCGYLS 214
                          ..|.|.|.:  ||.          |:.||     .:..::..|..
Human   265 VSCDARNFTLFHHPMHGNCYTFN--NRENETILSTSMGGSEYGLQVILYINEEEYNPFL------ 321

  Fly   215 NCITSLKPINSIVAPIFMYLHDVEEMMLPDDMRTPSFDAKDIESKDL-DIMLHTTSAESEVRNLP 278
                    ::|..|.:.  :|..:|....:|:.|      :||:..: .|.:|.|    |...|.
Human   322 --------VSSTGAKVI--IHRQDEYPFVEDVGT------EIETAMVTSIGMHLT----ESFKLS 366

  Fly   279 VAYRKCRFSDENNLQ----YYSPYHPSLCRLECRIKWALSLCNCKPYFYVAAPEVPICTV----S 335
            ..|.:|. .|.:::.    |.:.|...:|...|.....:..|.|..|.....|....|..    :
Human   367 EPYSQCT-EDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPN 430

  Fly   336 GMLC---LARSKWLERPCDCYPSCRE----ETFTIFK--------VSDQ------TGGDDNYSGE 379
            .|.|   |.|: :::....|...|:|    :.:|:..        ||::      |........:
Human   431 WMYCYYQLHRA-FVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNK 494

  Fly   380 RFERTLIINLQISRMGINRRVVF-----STDQLIMSFGGAIGLFLGASFMTIYGVV-YFFLTFIA 438
            :..:|.:..|.|....:|:|.:.     |.:.|:.:|||.:||::..|.:.:..:: .||:.|.:
Human   495 KLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFS 559

  Fly   439 YTCKNRFCK 447
            ...:.::.|
Human   560 IIARRQWQK 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk25	NP_995766.1	ASC	18..432	CDD:279230	107/563 (19%)
SCNN1G	NP_001030.2	ENaC	24..630	CDD:273304	113/590 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820