Protein Alignment ppk25 and SCNN1B

DIOPT Version :10

• Sequence 1: NP_995766.1
• Gene: ppk25 / 2768722
• FlyBaseID: FBgn0053349
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: XP_016879014.1
• Gene: SCNN1B / 6338
• HGNCID: 10600
• Length: 659
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 95/543 - (17%)
• Similarity: 176/543 - (32%)
• Gaps: 142/543 - (26%)

  Fly    18 CQESSIHGMPYIARRDLHWAERLFWTFIILGSAYYAISSCLNQWYRFRDNPIVYEYEYLF--GLR 80
            |..::.||...|.....  .::..|..:.|   .:|...|. ||..|....:.:|.....  |.:
Human    49 CDNTNTHGPKRIICEGP--KKKAMWFLLTL---LFAALVCW-QWGIFIRTYLSWEVSVSLSVGFK 107

  Fly    81 IFPFVGITLCP----RYHD------------ETEIPRLI-------NQT-------WGVDPSEDK 115
            ...|..:|:|.    :|..            |..:.|::       |.|       |...|....
Human   108 TMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLI 172

  Fly   116 EKAVYYRKFLLAINGLRYSTLETLEPFENDTTLDNVNYLNILLTLQKKVIAVKIPPELAPIITEV 180
            ::...:...:|.:.|..::.|.:....|.............|.:|.:.....:........:||.
Human   173 DERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEW 237

  Fly   181 GLCQTSSQLNRYGNPYGKLETQDMEPMKQCG--YLSNCITSLKPIN-----SIVAP----IFMYL 234
            .:.|.:       |.:.::..|::..|...|  .:..|:...:|.|     ||..|    .:::.
Human   238 YILQAT-------NIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFN 295

  Fly   235 HDVEEMMLPDDMRTPSFDAK---DIESKD----------LDIMLHTTSAESEVRN---------- 276
            ..:.|..||.......|..|   ||..:|          :.:|||...:...:|:
Human   296 WGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTE 360

  Fly   277 ------------LPVAYRKCRFS-DENNLQ-YYSPYHPS----LCRLECRIKWALSLCNCKPYFY 323
                        :...|..|..: .|..:| :||.|:.:    .|...|.....:..|||..|.|
Human   361 TSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLY 425

  Fly   324 VAA-----------PEVPICTVSGMLCLARSKWLERPCDCYPSCREE-TFTIFKVSDQTGGDDNY 376
            ...           |:...|.....:.:|:.:      .|...|:|. ..|.:|::.......:.
Human   426 PLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRE------TCIGMCKESCNDTQYKMTISMADWPSE 484

  Fly   377 SGERF-------ERTLIINLQISRMGI----------NRRVVFSTDQ-----LIMSFGGAIGLFL 419
            :.|.:       ||....|:.:||.||          |.|.:..:..     |:.:.||..|.::
Human   485 ASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWM 549

  Fly   420 GASFMTI--YGVV---YFFLTFI 437
            |.|.:.:  :|.:   :.::|.|
Human   550 GGSVLCLIEFGEIIIDFVWITII 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk25	NP_995766.1	ASC	18..432	CDD:459966	93/536 (17%)
SCNN1B	XP_016879014.1	ENaC	40..642	CDD:273304	95/543 (17%)