Protein Alignment ppk25 and SCNN1A

DIOPT Version :10

• Sequence 1: NP_995766.1
• Gene: ppk25 / 2768722
• FlyBaseID: FBgn0053349
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 108/615 - (17%)
• Similarity: 181/615 - (29%)
• Gaps: 231/615 - (37%)

  Fly     8 PKQP----DWLAE-----------LCQESSIHGMPYIARRDLHWAERLFWTFIIL---GSAYYAI 54
            |:||    :.|.|           .|..::|||...:.....:..:..||..:.|   |..|:..
Human    97 PQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQF 161

  Fly    55 SSCLNQWYRFRDNPIVYEYEYLFGLRIFPFVGITLC-------PRYHDE-TEIPRLINQTWGVDP 111
            .....:::.:   |:...........:||  .:|:|       |...:| .|:.|:..||
Human   162 GLLFGEYFSY---PVSLNINLNSDKLVFP--AVTICTLNPYRYPEIKEELEELDRITEQT----- 216

  Fly   112 SEDKEKAVYYRKFLLAINGLR----------------------------YSTLETLEPFENDTTL 148
            ..|..|   |..|...:.|.|                            .|...:|.  :|:..:
Human   217 LFDLYK---YSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLR--DNNPQV 276

  Fly   149 D-----------NVN-----------------------YLNILLTLQKKVIAVKIPPELAPIITE 179
            |           |.|                       |:|||..|          ||..|.:.|
Human   277 DWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRL----------PETLPSLEE 331

  Fly   180 ------VGLCQ----TSSQLN-------RYGNPYGKLETQDMEP-MKQCGYLSNCITSLK----- 221
                  :..|:    :.:|.|       .|||.|...:..:... |.....::|.::.:.
Human   332 DTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQN 396

  Fly   222 ---PINSIVAPIFMYLHDVEEMMLPDD--------------MRTPSFDAKDIESKDLDIMLHTTS 269
               |:.|.|....:.:|..:|....||              ||..:.|....:..|      .|.
Human   397 DFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGD------CTK 455

  Fly   270 AESEVRNLPVAYRKCRFSDENNLQYYSPYHPSLCRLECRIKWALSLCNCKPYFYVAAPEVPICTV 334
            ..|:|   ||          .|| |.|.|...:|...|..:..:..|.|...||.....|..|..
Human   456 NGSDV---PV----------ENL-YPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDY 506

  Fly   335 SGMLCLARSKW---------------------LERPCDC-----------YPSCREETFTIFKVS 367
            .     ..|.|                     ..:||..           :||...:.:....:|
Human   507 R-----KHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLS 566

  Fly   368 DQTGGDDNYSGERFERTLIINLQISRMGINRRVVFSTDQ---------LIMSFGGAIGLFLGASF 423
            .|    :||:... :|..:..:.|....:|    :.|:.         |:.:.|....|:.|:|.
Human   567 RQ----NNYTVNN-KRNGVAKVNIFFKELN----YKTNSESPSVTMVTLLSNLGSQWSLWFGSSV 622

  Fly   424 MTIY---GVVYFFLTFIAYTCKNRFCKRFF 450
            :::.   .:|:..|..:......||..|::
Human   623 LSVVEMAELVFDLLVIMFLMLLRRFRSRYW 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk25	NP_995766.1	ASC	18..432	CDD:459966	99/570 (17%)
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	103/599 (17%)