Protein Alignment ppk25 and ASIC4

DIOPT Version :9

• Sequence 1: NP_995766.1
• Gene: ppk25 / 2768722
• FlyBaseID: FBgn0053349
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: NP_061144.4
• Gene: ASIC4 / 55515
• HGNCID: 21263
• Length: 539
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 110/494 - (22%)
• Similarity: 171/494 - (34%)
• Gaps: 144/494 - (29%)

  Fly    11 PDWLAELCQESSIHGMPYIARRDLHWAERLFWTFIILGS--AYYAISSCLNQWYRFRDNPIVYEY 73
            |..||.....|::||:........|...|..|...:|.|  |:...::.|.:.|..|.:.:..:.
Human    39 PRDLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDP 103

  Fly    74 EYLFGLRIFPFVGITLC--PRYH----DETEIPRLINQTWGVDPSE-DKEKAVYYRKFLLAINGL 131
            .....:..||  .:|||  .|:.    .:.:|..|.|.| |:.|.: |..:|.          ||
Human   104 AAPAPVAGFP--AVTLCNINRFRHSALSDADIFHLANLT-GLPPKDRDGHRAA----------GL 155

  Fly   132 RYSTLETLEPFENDTTLDNVNYLNILLTLQKKVIAVKIPPELAPII------------------- 177
            ||.     ||       |.|:.||            :...:||.::
Human   156 RYP-----EP-------DMVDILN------------RTGHQLADMLKSCNFSGHHCSASNFSVVY 196

  Fly   178 TEVGLCQT------SSQLNRYGNPYGKLETQDMEPMKQCGYLSNCITSLKPI------NSIVAPI 230
            |..|.|.|      ||..:|.|.....||.  |..::|..||        ||      .|..|.|
Human   197 TRYGKCYTFNADPRSSLPSRAGGMGSGLEI--MLDIQQEEYL--------PIWRETNETSFEAGI 251

  Fly   231 FMYLHDVEEMMLPDDMR------TPSFDAKDIESKDLDIMLHTTSAESEVRNLPVAYRKCRFSD- 288
            .:.:|..||   |..:.      :|.|..            ..:..|..:..||..:..||...
Human   252 RVQIHSQEE---PPYIHQLGFGVSPGFQT------------FVSCQEQRLTYLPQPWGNCRAESE 301

  Fly   289 --ENNLQYYSPYHPSLCRLECRIKWALSLCNCK------------PYFYVAAPEVPICTVSGMLC 339
              |..||.||.|..|.|||.|..:..|..|:|:            |..|:...:..:.::.|
Human   302 LREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGG--- 363

  Fly   340 LARSKWLERPCDCYPSCREETF--TIFKVSDQTGGDDNYSGERFERT--------LIINL---QI 391
                 ..|.||.|...|....:  .|..|.....|...|...::.|.        |::::   .:
Human   364 -----GPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEAL 423

  Fly   392 SRMGINRRVVFSTDQLIMSFGGAIGLFLGASFMTIYGVV 430
            :...:.:|..:....|:...||.:|||:|||.:|:..::
Human   424 TSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEIL 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk25	NP_995766.1	ASC	18..432	CDD:279230	107/487 (22%)
ASIC4	NP_061144.4	ASC	40..488	CDD:413546	109/493 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7253
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.870