DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk25 and ASIC5

DIOPT Version :9

Sequence 1:	NP_995766.1	Gene:	ppk25 / 2768722	FlyBaseID:	FBgn0053349	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_059115.1	Gene:	ASIC5 / 51802	HGNCID:	17537	Length:	505	Species:	Homo sapiens

Alignment Length:	475	Identity:	90/475 - (18%)
Similarity:	174/475 - (36%)	Gaps:	98/475 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SSIHGMPYIARRDLHWAERLFWTFIILGS---AYYAISSCLNQWYRFRDNPIVYEYEYLFGLRIF 82
            :|.||:..|. ::.....|:.|..::|||   ..:.|...|..::.:.....: |.:|:..:.
Human    45 TSFHGIHNIV-QNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSI-EVQYVEKME-- 105

  Fly    83 PFVGITLCPRYHDETEIPR---LINQTWGVDPSEDKEKAVYYRKFLLAINGLRYSTLETLEPFEN 144
             |..:|.|.....:|:...   :|...|.:     ..|.::.::......|.|.:| :.....:|
Human   106 -FPAVTFCNLNRFQTDAVAKFGVIFFLWHI-----VSKVLHLQEITANSTGSREAT-DFAASHQN 163

  Fly   145 DTTLDNVN----YLNILLTLQKKVIAVKI-PPELAPIITEVGLC---------QTSSQLNRYGNP 195
            .:.::.:.    |||....|..:...... |.:.|.:.||.|.|         |...:::..|..
Human   164 FSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRG 228

  Fly   196 YGKLETQDMEPMKQCGYLSNCITSLKPINSIVAPIFMYLHDVEEMMLPDDMRTPSFDAKDIESKD 260
            ...|...:.|          ..|....:..:.|.|...:|..:        :.|.||...:.|
Human   229 LSLLFNVNQE----------AFTDNPALGFVDAGIIFVIHSPK--------KVPQFDGLGLLS-- 273

  Fly   261 LDIMLHTTSAESEVRNLPVAYRKCRFSDEN---NLQYYSPYHPSLCRLECRIKWALSLCNCKP-- 320
             .:.:|   |...:|.:...:::..:.:.|   .||.:|.|..|.|..||:.:.....|.|.|
Human   274 -PVGMH---ARVTIRQVKTVHQEYPWGECNPNIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFL 334

  Fly   321 ------------YFYVAAPEV------PICTVS--GMLCLARSKWLERPC----DCYPSCREETF 361
                        ||...:|.:      .:|||.  ...|....:.:|.|.    ..:||.:...:
Human   335 LPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKY 399

  Fly   362 TIFKVSDQTGGDDNYSGERFERTLIINLQISRMGINRRV-----VFSTDQLIMSFGGAIGLFLGA 421
            ...|::         ...::.|..::.::|:...:|.::     ..|..:|:...||.:|||.||
Human   400 LSKKLN---------QSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGA 455

  Fly   422 SFMTIYGVVYFFLTFIAYTC 441
            |.:||..::.:..|...:.|
Human   456 SLITIIEIIEYLFTNFYWIC 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk25	NP_995766.1	ASC	18..432	CDD:279230	88/464 (19%)
ASIC5	NP_059115.1	ASC	41..466	CDD:279230	88/464 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820