Protein Alignment ppk25 and asic4b

DIOPT Version :10

• Sequence 1: NP_995766.1
• Gene: ppk25 / 2768722
• FlyBaseID: FBgn0053349
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: NP_999951.1
• Gene: asic4b / 407667
• ZFINID: ZDB-GENE-040513-6
• Length: 558
• Species: Danio rerio
• Alignment Length: 497
• Identity: 112/497 - (22%)
• Similarity: 180/497 - (36%)
• Gaps: 136/497 - (27%)

  Fly    14 LAELCQESSIHGMPYIARRDLHWAERL-----FWTFIILGS----AYYAISSCLNQWYRFRDNPI 69
            ||.....||:||:    .|.|..:|||     .|...:|.|    .|.|..|...    :.:.|
Zfish    44 LASFASSSSLHGL----ARALGTSERLGFRQTLWGLALLVSLGLFLYQATWSAAT----YLERP- 99

  Fly    70 VYEYEYLFGLR-------IFPFVGITLC--PRYH----DETEIPRLINQTWGVDPSEDKEKAVYY 121
                 :|..||       .||  .||||  .|:.    .:.:|..|.|.| |:.|...|.    :
Zfish   100 -----HLAALREETRRELTFP--AITLCNVNRFRFSALTDADIYHLANLT-GLPPKSRKG----H 152

  Fly   122 RKFLLAINGLRYSTLETLEPFEN-----DTTLDNVNYLNILLTLQKKVIAVKIPPELAPIITEVG 181
            |.     :.|:|.....|:.|:.     :..|.:.|:.....:.:          :.:.:.|..|
Zfish   153 RP-----SELQYPPPNMLDIFQRTGHQLEDMLKSCNFSGQNCSSE----------DFSVVYTRYG 202

  Fly   182 LC------QTSSQLNRYGNPYGKLETQDMEPMKQCGYLSNCITSLKPI------NSIVAPIFMYL 234
            .|      :||.:..|.|.....||.  |..::|..||        ||      .::.|.|.:.:
Zfish   203 KCYTFNGNKTSPKRVRQGGTGNGLEM--MLDIQQDEYL--------PIWRETNETTLEAGIRVQI 257

  Fly   235 HDVEEMMLPDDMR------TPSFDAKDIESKDLDIMLHTTSAESEVRNLPVAYRKCRFSDENNLQ 293
            |...|   |..:.      :|.|..            ..:..|..:..||..:..||.|.|..:.
Zfish   258 HSQNE---PPYIHQLGFGVSPGFQT------------FVSCQEQRLTYLPQPWGNCRASSEPVIP 307

  Fly   294 YYSPYHPSLCRLECRIKWALSLCNCKPYFYVAAP-EVPICTVSGMLCLARS-----KWLERPCDC 352
            .|..|..|.|||.|........|||:   .|..| :..||..|.:.|:.::     |.....|.|
Zfish   308 GYDTYSVSACRLHCESTQVQRECNCR---MVHMPGDADICAPSKIKCVDKALASLQKSTGDSCPC 369

  Fly   353 YPSCR----EETFTIFKVSDQTGGDDNYSGERFERT--------LIINLQISRMG---INRRVVF 402
            ...|.    .:..::.|:..:  |...|...:::::        ||:::....:.   |.::..:
Zfish   370 ETPCNLTRYGKELSMVKIPSR--GSARYLSRKYQKSEEYIRDNFLILDIFFEALNYETIEQKKAY 432

  Fly   403 STDQLIMSFGGAIGLFLGASFMTIYGVVYFFLTFIAYTCKNR 444
            ....|:...||.:|||:|||.:||..:    |.:|....||:
Zfish   433 DIAGLLGDIGGQMGLFIGASILTILEI----LDYIYEVAKNK 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk25	NP_995766.1	ASC	18..432	CDD:459966	106/479 (22%)
asic4b	NP_999951.1	ENaC	54..497	CDD:273304	108/487 (22%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	450..452		1/1 (100%)