DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk25 and asic4b

DIOPT Version :9

Sequence 1:	NP_995766.1	Gene:	ppk25 / 2768722	FlyBaseID:	FBgn0053349	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_999951.1	Gene:	asic4b / 407667	ZFINID:	ZDB-GENE-040513-6	Length:	558	Species:	Danio rerio

Alignment Length:	497	Identity:	112/497 - (22%)
Similarity:	180/497 - (36%)	Gaps:	136/497 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LAELCQESSIHGMPYIARRDLHWAERL-----FWTFIILGS----AYYAISSCLNQWYRFRDNPI 69
            ||.....||:||:    .|.|..:|||     .|...:|.|    .|.|..|...    :.:.|
Zfish    44 LASFASSSSLHGL----ARALGTSERLGFRQTLWGLALLVSLGLFLYQATWSAAT----YLERP- 99

  Fly    70 VYEYEYLFGLR-------IFPFVGITLC--PRYH----DETEIPRLINQTWGVDPSEDKEKAVYY 121
                 :|..||       .||  .||||  .|:.    .:.:|..|.|.| |:.|...|.    :
Zfish   100 -----HLAALREETRRELTFP--AITLCNVNRFRFSALTDADIYHLANLT-GLPPKSRKG----H 152

  Fly   122 RKFLLAINGLRYSTLETLEPFEN-----DTTLDNVNYLNILLTLQKKVIAVKIPPELAPIITEVG 181
            |.     :.|:|.....|:.|:.     :..|.:.|:.....:.:          :.:.:.|..|
Zfish   153 RP-----SELQYPPPNMLDIFQRTGHQLEDMLKSCNFSGQNCSSE----------DFSVVYTRYG 202

  Fly   182 LC------QTSSQLNRYGNPYGKLETQDMEPMKQCGYLSNCITSLKPI------NSIVAPIFMYL 234
            .|      :||.:..|.|.....||.  |..::|..||        ||      .::.|.|.:.:
Zfish   203 KCYTFNGNKTSPKRVRQGGTGNGLEM--MLDIQQDEYL--------PIWRETNETTLEAGIRVQI 257

  Fly   235 HDVEEMMLPDDMR------TPSFDAKDIESKDLDIMLHTTSAESEVRNLPVAYRKCRFSDENNLQ 293
            |...|   |..:.      :|.|..            ..:..|..:..||..:..||.|.|..:.
Zfish   258 HSQNE---PPYIHQLGFGVSPGFQT------------FVSCQEQRLTYLPQPWGNCRASSEPVIP 307

  Fly   294 YYSPYHPSLCRLECRIKWALSLCNCKPYFYVAAP-EVPICTVSGMLCLARS-----KWLERPCDC 352
            .|..|..|.|||.|........|||:   .|..| :..||..|.:.|:.::     |.....|.|
Zfish   308 GYDTYSVSACRLHCESTQVQRECNCR---MVHMPGDADICAPSKIKCVDKALASLQKSTGDSCPC 369

  Fly   353 YPSCR----EETFTIFKVSDQTGGDDNYSGERFERT--------LIINLQISRMG---INRRVVF 402
            ...|.    .:..::.|:..:  |...|...:::::        ||:::....:.   |.::..:
Zfish   370 ETPCNLTRYGKELSMVKIPSR--GSARYLSRKYQKSEEYIRDNFLILDIFFEALNYETIEQKKAY 432

  Fly   403 STDQLIMSFGGAIGLFLGASFMTIYGVVYFFLTFIAYTCKNR 444
            ....|:...||.:|||:|||.:||..:    |.:|....||:
Zfish   433 DIAGLLGDIGGQMGLFIGASILTILEI----LDYIYEVAKNK 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk25	NP_995766.1	ASC	18..432	CDD:279230	106/479 (22%)
asic4b	NP_999951.1	ASC	54..497	CDD:295594	108/487 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920