Protein Alignment ppk25 and ASIC2

DIOPT Version :10

• Sequence 1: NP_995766.1
• Gene: ppk25 / 2768722
• FlyBaseID: FBgn0053349
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Alignment Length: 495
• Identity: 98/495 - (19%)
• Similarity: 178/495 - (35%)
• Gaps: 146/495 - (29%)

  Fly    25 GMPYIARRDLH---------------WAERLFWTFIILGSAYYAISSCLNQ---WYRFRDNPIVY 71
            |.|.::|..||               :..|..|......|....:|...|:   |..|..:..|:
Human    57 GRPSLSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTRVH 121

  Fly    72 -EYEYLFGLRIFPFVGITLCPRYHDETEIPRLI----------------NQTWGVDPSE----DK 115
             |:.     |..||..:|:|  .::....|||.                |:|.....||    |:
Human   122 REWS-----RQLPFPAVTVC--NNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRGDE 179

  Fly   116 EKAVYYRK---FLLAINGLRYSTLETLEPFENDTTLDNVNYLNILLTLQKKVIAVKIPPELAPII 177
            .:..::||   |.|.:....:..:..       ..:|.:.:     .|:..:::.|...||.
Human   180 PRRQWFRKLADFRLFLPPRHFEGISA-------AFMDRLGH-----QLEDMLLSCKYRGELC--- 229

  Fly   178 TEVGLCQTSSQLNRYGNPYGKLETQDMEPMKQCGYLSNCITSLKPINSIVAPIFMYLHDVEEMML 242
               |....||...:||..|.....:|.:|:         :|::|........|.:.:...|.:.:
Human   230 ---GPHNFSSVFTKYGKCYMFNSGEDGKPL---------LTTVKGGTGNGLEIMLDIQQDEYLPI 282

  Fly   243 PDDMRTPSFDAKDIESKDLDIMLHTTS----------------------AESEVRNLPVAYRKCR 285
            ..:....:|:|      .:.:.:|:.|                      .|..:..||..:.:||
Human   283 WGETEETTFEA------GVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECR 341

  Fly   286 FSDENNLQYYSPYHPSLCRLECRIKWALSLCNCKPYFYVAAP-EVPICT----------VSGML- 338
             |.|..|.::..|..:.||::|..::.:..|||:   .|..| :.|.||          ..|:|
Human   342 -SSEMGLDFFPVYSITACRIDCETRYIVENCNCR---MVHMPGDAPFCTPEQHKECAEPALGLLA 402

  Fly   339 ------CLARSKWLERPCDCYPSCREETFTIFKVSDQTGGDDNYSGERF--------ERTLIINL 389
                  ||.|:     ||:.....:|  .::.|:..:|..  .|..::|        |..|::::
Human   403 EKDSNYCLCRT-----PCNLTRYNKE--LSMVKIPSKTSA--KYLEKKFNKSEKYISENILVLDI 458

  Fly   390 QISRMG---INRRVVFSTDQLIMSFGGAIGLFLGASFMTI 426
            ....:.   |.::..:....|:...||.:|||:|||.:||
Human   459 FFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTI 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk25	NP_995766.1	ASC	18..432	CDD:459966	98/495 (20%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	95/488 (19%)