Protein Alignment ppk25 and Scnn1a

DIOPT Version :10

• Sequence 1: NP_995766.1
• Gene: ppk25 / 2768722
• FlyBaseID: FBgn0053349
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: NP_113736.1
• Gene: Scnn1a / 25122
• RGDID: 3639
• Length: 699
• Species: Rattus norvegicus
• Alignment Length: 629
• Identity: 100/629 - (15%)
• Similarity: 180/629 - (28%)
• Gaps: 253/629 - (40%)

  Fly     6 SRPKQP----DWLAE-----------LCQESSIHG------MPYIARRDLHWA-------ERLFW 42
            |.|:||    :.|.|           .|..::|||      ..:...:...||       ..::|
  Rat    62 SAPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYW 126

  Fly    43 TFIILGSAYY------------------AISSCLNQWYRFRDNPIVYE-------------YEY- 75
            .|.:|...|.                  |::.|....||:.:.....|             |:|
  Rat   127 QFALLFEEYLSYPVSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEELEELDRITEQTLFDLYKYN 191

  Fly    76 ----------------LFGLRIFPFVGI-TLCPRYHDET----------EIPRLINQTW--GVDP 111
                            |.|....|...: |..|.|...|          ..|::..:.|  |...
  Rat   192 SSYTRQAGARRRSSRDLLGAFPHPLQRLRTPPPPYSGRTARSGSSSVRDNNPQVDRKDWKIGFQL 256

  Fly   112 SEDKEKAVYYRKFLLAINGLR--YSTLETLEPFENDTTLDNVNYLNILLTLQKKVIAVKIPPELA 174
            ....:...:|:.:...::.:|  |                ..:|:|||..|.          :.:
  Rat   257 CNQNKSDCFYQTYSSGVDAVREWY----------------RFHYINILSRLS----------DTS 295

  Fly   175 PIITEVGL------CQTS----SQLN-------RYGNPY--GKLETQDMEPMKQCGYLSNCITSL 220
            |.:.|..|      |:.:    :|.|       .|||.|  ......::......|..:....:|
  Rat   296 PALEEEALGNFIFTCRFNQAPCNQANYSKFHHPMYGNCYTFNDKNNSNLWMSSMPGVNNGLSLTL 360

  Fly   221 K-------PINSIVAPIFMYLHDVEEMMLPDD--------------MRTPSFDA-----KDIESK 259
            :       |:.|.|....:.:|..:|....||              ||..:.|:     .|....
  Rat   361 RTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKEALDSLGGNYGDCTEN 425

  Fly   260 DLDIMLHTTSAESEVRNLPVAYRKCRFSDENNLQYYSPYHPSLCRLECRIKWALSLCNCKPYFYV 324
            ..|:         .|:||                |.|.|...:|...|..:..:..|.|...||.
  Rat   426 GSDV---------PVKNL----------------YPSKYTQQVCIHSCFQENMIKKCGCAYIFYP 465

  Fly   325 AAPEVPIC-------------------TVSGMLCLARSKWLERPCDC-----------YPSCREE 359
            ....|..|                   ::..:.|.::.:   :||..           :||.:.:
  Rat   466 KPKGVEFCDYRKQSSWGYCYYKLQGAFSLDSLGCFSKCR---KPCSVINYKLSAGYSRWPSVKSQ 527

  Fly   360 TFTIFKVSDQTGGDDNYSGERFERTLIINLQISRMGINRRVVFSTD---------------QLIM 409
            .:....:|.|    :||:           :...|.|:.:..:|..:               .|:.
  Rat   528 DWIFEMLSLQ----NNYT-----------INNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLS 577

  Fly   410 SFGGAIGLFLGASFMTIY---GVVYFFLTFIAYTCKNRFCKRFF 450
            :.|....|:.|:|.:::.   .:::..|.........||..|::
  Rat   578 NLGSQWSLWFGSSVLSVVEMAELIFDLLVITLLMLLRRFRSRYW 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk25	NP_995766.1	ASC	18..432	CDD:459966	90/582 (15%)
Scnn1a	NP_113736.1	ENaC	80..677	CDD:273304	94/611 (15%)