DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk25 and Scnn1g

DIOPT Version :9

Sequence 1:	NP_995766.1	Gene:	ppk25 / 2768722	FlyBaseID:	FBgn0053349	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_058742.2	Gene:	Scnn1g / 24768	RGDID:	3641	Length:	650	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	99/581 - (17%)
Similarity:	189/581 - (32%)	Gaps:	172/581 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PKQP---DWLAELCQESSIHGMPYIA-----RRDLHW-------AERLFWTFIILGSAYYAISSC 57
            |:.|   |.:...|..::.||...|.     .|.|.|       ...:.|...:|..::|.:|..
  Rat    20 PQAPTIKDLMHWYCMNTNTHGCRRIVVSRGRLRRLLWIAFTLTAVALIIWQCALLVFSFYTVSVS 84

  Fly    58 LNQWYRFRDNPIV-------YEYEYLFGL----------RIFPFVGITLCPRYHDETEIPRLINQ 105
            :...::..|.|.|       |:|..:..|          .:....|:....:..:...:|..:.
  Rat    85 IKVHFQKLDFPAVTICNINPYKYSAVSDLLTDLDSETKQALLSLYGVKESRKRREAGSMPSTLE- 148

  Fly   106 TWGVDP------------SEDKEKAVYYRKFLL-------------AINGLRYSTLETLEPFE-- 143
              |..|            ..:|.||   |.|..             |.|.:.....:.|..|:
  Rat   149 --GTPPRFFKLIPLLVFNENEKGKA---RDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLC 208

  Fly   144 -NDTTLD-----------------NVNYLNIL--LTLQKKVIAVKIPPELAPIITEVGLCQTSSQ 188
             |||: |                 .::|:||:  :.|:||:.......||.......|:...:..
  Rat   209 SNDTS-DCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAKELLVTCFFDGMSCDARN 272

  Fly   189 LNRYGNP-YGKLETQDMEPMKQCGYLSNCITSLKPINSIV-----------APIFMYLHDVE--- 238
            ...:.:| ||                 ||.|.....|:.:           ..:.:|:::.|
  Rat   273 FTLFHHPMYG-----------------NCYTFNNKENATILSTSMGGSEYGLQVILYINEDEYNP 320

  Fly   239 --------EMMLPDDMRTPSFDAKDIE---SKDLDIMLHTTSAESEVRNLPVAYRKCRFSDENNL 292
                    ::::......|..:...:|   :....|.:|.|    |...|...|.:|. .|.:::
  Rat   321 FLVSSTGAKVLIHQQNEYPFIEDVGMEIETAMSTSIGMHLT----ESFKLSEPYSQCT-EDGSDV 380

  Fly   293 Q----YYSPYHPSLCRLECRIKWALSLCNCKPYFYVAAPEVPICTV----SGMLCLAR--SKWLE 347
            .    |.:.|...:|...|.....:..|.|..|.....|....|..    :.|.|..:  ..::.
  Rat   381 PVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLYQAFVR 445

  Fly   348 RPCDCYPSCREETFTIFKVSDQTGGDDNYSGERFERTLI----------INLQISRMGINRRVVF 402
            ....|...|::.  ..||....|.....:..|..|:.|:          ||.::::..:.:.::|
  Rat   446 EELGCQSVCKQS--CSFKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQINKKLNKTDLAKLLIF 508

  Fly   403 ---------------STDQLIMSFGGAIGLFLGASFMTIYGVV-YFFLTFIAYTCKNRFCK 447
                           |.:.|:.:|||.:||::..|.:.:..:: .||:.|.:...:.::.|
  Rat   509 YKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWHK 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk25	NP_995766.1	ASC	18..432	CDD:279230	92/551 (17%)
Scnn1g	NP_058742.2	ENaC	24..631	CDD:273304	97/577 (17%)
Scnn1g	NP_058742.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820