DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk25 and Scnn1g

DIOPT Version :10

Sequence 1:NP_995766.1 Gene:ppk25 / 2768722 FlyBaseID:FBgn0053349 Length:451 Species:Drosophila melanogaster
Sequence 2:NP_058742.2 Gene:Scnn1g / 24768 RGDID:3641 Length:650 Species:Rattus norvegicus


Alignment Length:581 Identity:99/581 - (17%)
Similarity:189/581 - (32%) Gaps:172/581 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 PKQP---DWLAELCQESSIHGMPYIA-----RRDLHW-------AERLFWTFIILGSAYYAISSC 57
            |:.|   |.:...|..::.||...|.     .|.|.|       ...:.|...:|..::|.:|..
  Rat    20 PQAPTIKDLMHWYCMNTNTHGCRRIVVSRGRLRRLLWIAFTLTAVALIIWQCALLVFSFYTVSVS 84

  Fly    58 LNQWYRFRDNPIV-------YEYEYLFGL----------RIFPFVGITLCPRYHDETEIPRLINQ 105
            :...::..|.|.|       |:|..:..|          .:....|:....:..:...:|..:. 
  Rat    85 IKVHFQKLDFPAVTICNINPYKYSAVSDLLTDLDSETKQALLSLYGVKESRKRREAGSMPSTLE- 148

  Fly   106 TWGVDP------------SEDKEKAVYYRKFLL-------------AINGLRYSTLETLEPFE-- 143
              |..|            ..:|.||   |.|..             |.|.:.....:.|..|:  
  Rat   149 --GTPPRFFKLIPLLVFNENEKGKA---RDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLC 208

  Fly   144 -NDTTLD-----------------NVNYLNIL--LTLQKKVIAVKIPPELAPIITEVGLCQTSSQ 188
             |||: |                 .::|:||:  :.|:||:.......||.......|:...:..
  Rat   209 SNDTS-DCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAKELLVTCFFDGMSCDARN 272

  Fly   189 LNRYGNP-YGKLETQDMEPMKQCGYLSNCITSLKPINSIV-----------APIFMYLHDVE--- 238
            ...:.:| ||                 ||.|.....|:.:           ..:.:|:::.|   
  Rat   273 FTLFHHPMYG-----------------NCYTFNNKENATILSTSMGGSEYGLQVILYINEDEYNP 320

  Fly   239 --------EMMLPDDMRTPSFDAKDIE---SKDLDIMLHTTSAESEVRNLPVAYRKCRFSDENNL 292
                    ::::......|..:...:|   :....|.:|.|    |...|...|.:|. .|.:::
  Rat   321 FLVSSTGAKVLIHQQNEYPFIEDVGMEIETAMSTSIGMHLT----ESFKLSEPYSQCT-EDGSDV 380

  Fly   293 Q----YYSPYHPSLCRLECRIKWALSLCNCKPYFYVAAPEVPICTV----SGMLCLAR--SKWLE 347
            .    |.:.|...:|...|.....:..|.|..|.....|....|..    :.|.|..:  ..::.
  Rat   381 PVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLYQAFVR 445

  Fly   348 RPCDCYPSCREETFTIFKVSDQTGGDDNYSGERFERTLI----------INLQISRMGINRRVVF 402
            ....|...|::.  ..||....|.....:..|..|:.|:          ||.::::..:.:.::|
  Rat   446 EELGCQSVCKQS--CSFKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQINKKLNKTDLAKLLIF 508

  Fly   403 ---------------STDQLIMSFGGAIGLFLGASFMTIYGVV-YFFLTFIAYTCKNRFCK 447
                           |.:.|:.:|||.:||::..|.:.:..:: .||:.|.:...:.::.|
  Rat   509 YKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWHK 569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk25NP_995766.1 ASC 18..432 CDD:459966 92/551 (17%)
Scnn1gNP_058742.2 ENaC 24..631 CDD:273304 97/577 (17%)
Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000250|UniProtKB:P51170 135..222 16/93 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 577..628
PY motif, mediates interaction, ubiquitination and inhibition by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:12654927 624..628
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P51170 624..628
Blue background indicates that the domain is not in the aligned region.

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