DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk25 and Scnn1b

DIOPT Version :9

Sequence 1:	NP_995766.1	Gene:	ppk25 / 2768722	FlyBaseID:	FBgn0053349	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_001258952.1	Gene:	Scnn1b / 20277	MGIID:	104696	Length:	638	Species:	Mus musculus

Alignment Length:	569	Identity:	102/569 - (17%)
Similarity:	181/569 - (31%)	Gaps:	184/569 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CQESSIHGMPYIARRDLHWAERLFWTFIILGSAYYAISSCLN--QWYRFRDNPIVYE--YEYLFG 78
            |..::.||...|.....  .::..|..:.|      :.:||.  ||..|....:.:|  .....|
Mouse    30 CNNTNTHGPKRIICEGP--KKKAMWFLLTL------LFACLVCWQWGVFIQTYLSWEVSVSLSMG 86

  Fly    79 LRIFPFVGITLC---PRYHDETEIPRLINQTWGVDPSEDKEKAVYYRKFLLAINGLRYSTLETLE 140
            .:...|..:|:|   |..:  :::..|:...      ::..:||..:  :||......:|..||.
Mouse    87 FKTMNFPAVTVCNSSPFQY--SKVKHLLKDL------DELMEAVLEK--ILAPEASHSNTTRTLN 141

  Fly   141 -PFENDTTL--------DNVNYLNI--------------------------LLTLQKKVIAVKIP 170
             ...|.|.|        |:...||:                          |.:....|..::..
Mouse   142 FTIWNHTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLCSANGTVCTLRNF 206

  Fly   171 PELAPIITEVGLCQTSSQLNRYGNPYGKLETQDMEPMKQCGYLSN-----CITSLKPI-NSIVAP 229
            ......:||..:.|.:       |.:.::..||:..|   ||..:     |:...:|. :....|
Mouse   207 TSATQAVTEWYILQAT-------NIFSQVLPQDLVGM---GYAPDRIILACLFGTEPCSHRNFTP 261

  Fly   230 IF------MYLHD--VEEMMLPDDMRTPSFDAK---DIESKD----------LDIMLHTTSAESE 273
            ||      .|:.:  :.|..||.......|..|   ||..:|          ..:|||      |
Mouse   262 IFYPDYGNCYIFNWGMTEETLPSANPGTEFGLKLILDIGQEDYVPFLASTAGARLMLH------E 320

  Fly   274 VRNLPV----------------------------AYRKCRFSDEN----NLQ--YYSPYHPSLCR 304
            .|..|.                            .|..|..:..:    ||.  |.:.|....|.
Mouse   321 QRTYPFIREEGIYAMAGTETSIGVLVDKLQRKGEPYSPCTMNGSDVAIKNLYSVYNTTYSIQACL 385

  Fly   305 LECRIKWALSLCNCKPYFYVAA-----------PEVPICTVSGMLCLARSKWLERPCDCYPSCRE 358
            ..|.....:..|:|..|.|...           |:...|.::..:.:.:.:      .|...|:|
Mouse   386 HSCFQDHMIRNCSCGHYLYPLPEGEKYCNNRDFPDWAYCYLNLQMSVTQRE------TCLSMCKE 444

  Fly   359 E-TFTIFKVSDQTGGDDNYSGERF-------ERTLIINLQISRMGI----------NRRVVFSTD 405
            . ..|.:|::.......:.:.|.:       ||....|:.:||.||          |.|.:..:.
Mouse   445 SCNDTQYKMTISMADWPSEASEDWILHVLSQERDQSSNITLSRKGIVKLNIYFQEFNYRTIEESP 509

  Fly   406 Q-----LIMSFGGAIGLFLGASFMTI--YGVV---YFFLTFI--AYTCK 442
            .     |:.:.||..|.::|.|.:.:  :|.:   :.::|.|  ..:||
Mouse   510 ANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITIIKLVASCK 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk25	NP_995766.1	ASC	18..432	CDD:279230	98/555 (18%)
Scnn1b	NP_001258952.1	ENaC	21..621	CDD:273304	102/569 (18%)
		deg-1	29..538	CDD:273309	97/547 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820