DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12d1-d and KAO2

DIOPT Version :9

Sequence 1:	NP_995812.1	Gene:	Cyp12d1-d / 2768720	FlyBaseID:	FBgn0053503	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001189657.1	Gene:	KAO2 / 817805	AraportID:	AT2G32440	Length:	489	Species:	Arabidopsis thaliana

Alignment Length:	489	Identity:	119/489 - (24%)
Similarity:	192/489 - (39%)	Gaps:	105/489 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 NKFKFMRAFMPGG--EFQNASITEYTSAMRKRYG--DIYVMPGMFGRK-DWVTTFNTKDIEMVFR 108
            |.:.|:|||....  .|..:.||        |||  .|| ...|||.. ..|||..|  ...|..
plant    56 NMWSFLRAFKTSDPESFIQSYIT--------RYGRTGIY-KAHMFGYPCVLVTTPET--CRRVLT 109

  Fly   109 NEGI----WPRRD----GLDSIV--YFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPR 163
            ::..    ||:..    |..|.|  .|.||.|                    ||...:.....|.
plant   110 DDDAFHIGWPKSTMKLIGRKSFVGISFEEHKR--------------------LRRLTSAPVNGPE 154

  Fly   164 GLRMYYEPLSNINNEFIERIKEIRDPKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDN 228
            .|.:|.:.:....|..:|:..::.:       .:|...:.:|.|:.:..:.      |..::...
plant   155 ALSVYIQFIEETVNTDLEKWSKMGE-------IEFLSHLRKLTFKVIMYIF------LSSESEHV 206

  Fly   229 SDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKMKRTLNDSLNVSQKMLKENQDALEKRR- 292
            .|:|     .|:...|.:.:....     |:.|.:     ..:.:|...:|::...|..:..||
plant   207 MDSL-----EREYTNLNYGVRAMG-----INLPGF-----AYHRALKARKKLVAAFQSIVTNRRN 256

  Fly   293 QAGEKINSN--SMLERLMEI--------DPKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDK 347
            |..:.|:||  .||:.|:::        |.:..:.:.|..|.||.:::..|.....:.:.:||..
plant   257 QRKQNISSNRKDMLDNLIDVKDENGRVLDDEEIIDLLLMYLNAGHESSGHLTMWATILMQEHPMI 321

  Fly   348 QAKLREELLSIM----PTKDSLLNEENMKDMPYLRAVIKETLRYYPNGFGTMRTCQNDVILSGYR 408
            ..|.:||...|:    |.:...|.|  .::|.||..||.||||.........|..::||.:.||.
plant   322 LQKAKEEQERIVKKRAPGQKLTLKE--TREMVYLSQVIDETLRVITFSLTAFREAKSDVQMDGYI 384

  Fly   409 VPKGTTVLLGSNVLMKEATYYPRPDEFLPERWL-RDPETGKKMQVSPFTFLPFGFGPRMCIGKRV 472
            :|||..||.....:..:...||.|.:|.|.||. ..|:.|        ||||||.|..:|.|..:
plant   385 IPKGWKVLTWFRNVHLDPEIYPDPKKFDPSRWEGYTPKAG--------TFLPFGLGSHLCPGNDL 441

  Fly   473 VDLEMETTVAKLIRNFHVEFNRDASRP-FKTMFL 505
            ..||    ::..:.:|.:::..:.|.| ...|||
plant   442 AKLE----ISIFLHHFLLKYRVERSNPGCPVMFL 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-d	NP_995812.1	p450	70..508	CDD:299894	111/466 (24%)
KAO2	NP_001189657.1	PLN02302	2..489	CDD:215171	119/489 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920