DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12d1-d and cyp11a1

DIOPT Version :9

Sequence 1:	NP_995812.1	Gene:	Cyp12d1-d / 2768720	FlyBaseID:	FBgn0053503	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_694485.2	Gene:	cyp11a1 / 80374	ZFINID:	ZDB-GENE-010306-1	Length:	509	Species:	Danio rerio

Alignment Length:	543	Identity:	130/543 - (23%)
Similarity:	239/543 - (44%)	Gaps:	83/543 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TLSSARSVAIYVGPVRSSRSASVLAHEQAKSSITEEHKTYDEIPRPNKFKFMRAFMPGGEFQNA- 66
            :|||.::: :.|...||.|:..       .|::    :.:::||              |.::|:
Zfish    14 SLSSLKNL-LQVKVTRSGRAPQ-------NSTV----QPFNKIP--------------GRWRNSL 52

  Fly    67 -SITEYT--SAMR----------KRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDG 118
             |:..:|  ..:|          |.:|.||  ....|..|.|.....:|..::|:.||..|.|..
Zfish    53 LSVLAFTKMGGLRNVHRIMVHNFKTFGPIY--REKVGIYDSVYIIKPEDGAILFKAEGHHPNRIN 115

  Fly   119 LDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERI 183
            :|:...:|:: |...|    |::..:.:||...|..:|...:.|:....:...|..:..:|:.|:
Zfish   116 VDAWTAYRDY-RNQKY----GVLLKEGKAWKTDRMILNKELLLPKLQGTFVPLLEEVGQDFVARV 175

  Fly   184 -KEIRDPKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTFK 247
             |:|......:...|.|.::.:...||:..|.:..::||:..|.|..     ||...|...:.||
Zfish   176 NKQIERSGQKQWTTDLTHDLFKFSLESVSAVLYGERLGLLLDNIDPE-----FQHFIDCVSVMFK 235

  Fly   248 -----LDIQPSMWKIISTPTYRKMKRTLNDSLNVSQ-------KMLKENQDALEKRRQAGEKINS 300
                 |.:.|.:.:.|.:..::......:...|.:.       |..|||.:...|....   :..
Zfish   236 TTSPMLYLPPGLLRSIGSNIWKNHVEAWDGIFNQADRYIQNIFKQWKENPEGNGKYPGV---LAI 297

  Fly   301 NSMLERLMEIDPKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELLSI-MPTKDS 364
            ..|.::|...|.|.:|   .:::..|||:....|...|..|::.||.|.:||.|:.:. :..|..
Zfish   298 LLMQDKLSIEDIKASV---TELMAGGVDSVTFTLLWTLYELARQPDLQDELRAEISAARIAFKGD 359

  Fly   365 LLNEENMKDMPYLRAVIKETLRYYPNGFGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYY 429
            ::  :.:|.:|.|:|.:|||||.:|......|....|.::..|.:|.||.|.||...:.::..::
Zfish   360 MV--QMVKMIPLLKAALKETLRLHPVAMSLPRFITEDTVIQNYHIPAGTLVQLGVYAMGRDHQFF 422

  Fly   430 PRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNR 494
            |:|:::.|.||:     ..|.|.  |..|.||||||.|:|:|:.:.||:..:..::.||.:|..:
Zfish   423 PKPEQYCPSRWI-----SSKRQY--FKSLGFGFGPRQCLGRRIAETEMQIFLIHMLENFRIEKQK 480

  Fly   495 --DASRPFKTMFLMEPAITFPFK 515
              :....|:.:.:.|..|....|
Zfish   481 QIEVRSKFELLLMPEKPIMLTIK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-d	NP_995812.1	p450	70..508	CDD:299894	114/465 (25%)
cyp11a1	NP_694485.2	p450	66..502	CDD:278495	114/462 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820