DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12d1-d and cyp27c1

DIOPT Version :9

Sequence 1:	NP_995812.1	Gene:	Cyp12d1-d / 2768720	FlyBaseID:	FBgn0053503	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001106808.2	Gene:	cyp27c1 / 558396	ZFINID:	ZDB-GENE-080204-68	Length:	540	Species:	Danio rerio

Alignment Length:	533	Identity:	139/533 - (26%)
Similarity:	258/533 - (48%)	Gaps:	62/533 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SSRSASVLAHEQA----KSSITEEH--------KTYDEIPRPNKFKFMRAFMPGGEFQNASITEY 71
            :|.|..:.||.||    :|:::...        |:..|:|.|:....:..|.....|  :.|.|.
Zfish    35 ASGSLEIAAHSQADLKEESAVSPAEEVQKAARVKSLKEMPGPSTVANLLEFFYRDGF--SRIHEI 97

  Fly    72 TSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGE 136
            .....|:||.|:  ...||.:..|:..:...:..|.|:|...|:|..::|...:|     |:.|.
Zfish    98 QMEHAKKYGKIF--KSRFGPQFVVSIADRDMVAQVLRSESATPQRGNMESWKEYR-----DLRGR 155

  Fly   137 VQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEIR----DPKTLEVPED 197
            ..||::::.:.|.|:||.:..:.|:||.:.::...::::..:.::|:|.:|    |.:|:   .:
Zfish   156 STGLISAEGDEWLKMRSVLRQLIMRPRDVAVFSSDVNDVVADLVKRVKTLRSQQDDSQTV---LN 217

  Fly   198 FTDEISRLVFESLGLVAFDRQMGLI-----RKNRDNSDALTLFQTSRDIFRLTFKLDIQPSMWKI 257
            ..|...:...|.:..:.::.::|.:     :.:::...||.|..:|   |:.|......|...:.
Zfish   218 INDLFFKYAMEGVATILYETRLGCLENEIPKMSQEYITALHLMFSS---FKTTMYAGAIPKWLRP 279

  Fly   258 ISTPTYRKMKRTLNDSLNVSQ----KMLKENQDALEKRRQAGEKINSNSMLERLMEIDPKVAVIM 318
            |....:.:...:.:.....||    |.|.|.:..:||..:....:.::.::.|.|.::...|.:
Zfish   280 IIPKPWEEFCSSWDGLFKFSQIHVDKRLSEIKKQMEKSEEIKGGLLTHMLVTREMNLEEIYANM- 343

  Fly   319 SLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIM----PTKDSLLNEENMKDMPYL-- 377
             .::|.||||.|:..||.....|::||..|.::.||:..::    ||.:         |:|||
Zfish   344 -TEMLLAGVDTTSFTLSWSTYLLARHPTIQQQIFEEVDRVLGGRVPTGE---------DVPYLPL 398

  Fly   378 -RAVIKETLRYYPNGFGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWL 441
             |.::|||||.:|...|..|...:|:|:.||.:||||.:.|.......:...:|||:||.|:||:
Zfish   399 IRGLVKETLRLFPVLPGNGRVTHDDLIVGGYLIPKGTQLALCHYSTSMDEENFPRPEEFRPDRWI 463

  Fly   442 RDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNRDASRPF-KTMFL 505
            |...:.:   |..|..:|||:|.|.|||:|:.:|||...:.:|::|||:|.:...:... ||..|
Zfish   464 RKDASDR---VDNFGSIPFGYGIRSCIGRRIAELEMHLALTQLLQNFHIEVSPQTTEVHAKTHGL 525

  Fly   506 MEPAITFPFKFTD 518
            :.|..:...:|||
Zfish   526 LCPGASINLRFTD 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-d	NP_995812.1	p450	70..508	CDD:299894	121/458 (26%)
cyp27c1	NP_001106808.2	p450	74..517	CDD:306555	123/471 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.830