DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12d1-d and si:ch211-113j14.1

DIOPT Version :9

Sequence 1:	NP_995812.1	Gene:	Cyp12d1-d / 2768720	FlyBaseID:	FBgn0053503	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_686522.4	Gene:	si:ch211-113j14.1 / 558239	ZFINID:	ZDB-GENE-120215-110	Length:	573	Species:	Danio rerio

Alignment Length:	507	Identity:	132/507 - (26%)
Similarity:	251/507 - (49%)	Gaps:	49/507 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 QAKSSITEEHKTYDEIPRPN-----KFKFMRAFMPGGEFQNASITEYTSAMRKRYGDIYVMPGMF 89
            |:.::||..:||.|::|.||     .:.|::.:   .:..:|...|:    ::.||.|:  ...|
Zfish    92 QSANTITGRYKTKDDLPGPNLATTVYWLFVKGY---ADKSHAMQVEH----KRLYGPIW--RSRF 147

  Fly    90 GRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSA 154
            |..|.:.......|..|.|.||.:|.|..|.   ::||:  .|:.|:..|:.......|.::|||
Zfish   148 GPFDVINVAGADLIAQVIRQEGRYPVRTDLP---HWREY--RDMRGQAYGIHVDTGPEWYRIRSA 207

  Fly   155 INPIFMQPRGLRMYYEPLSNINNEFIERIK--EIRDPKTLEVPEDFTDEISRLVFESLGLVAFDR 217
            :||..::.:.:..|...:..:.::.::|::  .:|.|..:.| .|...|:.:..||.:..:.|:.
Zfish   208 LNPKMLKLKEVTAYAPIIHEVVSDLLQRLELLRLRSPDQITV-SDLASELYKFGFEGISSILFET 271

  Fly   218 QMGLIRKNRDNSDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKMKRTLNDSLNVSQKMLK 282
            ::|.:::... :|.|.......::..|:..:...| .|.....|.:::..:..::..:|::.::.
Zfish   272 RLGCLQEEIP-TDTLRFISAVNEMLALSETVLFFP-RWTRHIFPFWKRFVQAWDELYDVARHLID 334

  Fly   283 ENQDALEKRRQAGEKI---------NSNSMLERLMEIDPKVAVIMSLDILFAGVDATATLLSAVL 338
            :..:.:..:...||::         :||.:  .|.|:     .|...::|..|||.|:..||..|
Zfish   335 KKVNEIRDQVARGEEVEGMYLTYLLSSNKL--SLGEV-----YISLTELLLGGVDTTSNTLSWTL 392

  Fly   339 LCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKETLRYYPNGFGTMR-TCQNDV 402
            ..|:::|:.|.:|..|::|:.|.| .:.|.:::..|||::|||||.||.||...|..| |..:|:
Zfish   393 YHLARNPEIQKRLHNEIVSVCPNK-KVPNTDDLTKMPYMKAVIKEILRMYPVVPGNGRLTVDSDI 456

  Fly   403 ILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMC 467
            ::..|..||.|...|....:..:...:|..:.|:||||:||  :..:.|..|::.:|||.|.|.|
Zfish   457 VVDNYWFPKKTQFHLCHYAVSHDENNFPDAERFVPERWIRD--SPSRSQHHPYSSVPFGVGVRAC 519

  Fly   468 IGKRVVDLEMETTVAKLIRNFHVEFNRDASRPF---KTMFLMEPAITFPFKF 516
            :||||.:|||...:::|::.:  |....|..|.   ||..|:.|:.....:|
Zfish   520 VGKRVAELEMYFALSRLMQQY--EVRTKAGSPSIQPKTRTLLIPSQPIDLQF 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-d	NP_995812.1	p450	70..508	CDD:299894	119/452 (26%)
si:ch211-113j14.1	XP_686522.4	p450	108..569	CDD:278495	125/489 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.830