Protein Alignment Cyp12d1-d and Cyp46a1

DIOPT Version :9

• Sequence 1: NP_995812.1
• Gene: Cyp12d1-d / 2768720
• FlyBaseID: FBgn0053503
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_006240610.1
• Gene: Cyp46a1 / 362782
• RGDID: 1306605
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 494
• Identity: 121/494 - (24%)
• Similarity: 222/494 - (44%)
• Gaps: 66/494 - (13%)

  Fly    22 SASVLAHEQAKSSITEEHKTYDEIPRPNKFKFMRAFMP---------GGEFQNASITEYTSAMRK 77
            ||.:||.....:.:......|:.||.|.:..|:...:|         |...|:..:.     ..|
  Rat    10 SAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPYFWKKDEACGRVLQDVFLD-----WAK 69

  Fly    78 RYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGE---VQG 139
            :||.: |...:|.:...:.|    ..|.|  .:.:...:...||.:|   .....|:||   .||
  Rat    70 KYGPV-VRVNVFHKTSVIVT----SPESV--KKFLMSTKYNKDSKMY---RAIQTVFGERLFGQG 124

  Fly   140 LVASQNEA-WGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEIRDPKT-LEVPEDFTDEI 202
            ||:..:.. |.|.|..::..|.     |.....|....||..|::.||.:.|. .:.|....|.:
  Rat   125 LVSECDYGRWYKQRRVMDLAFS-----RSSLVSLMGTFNEKAEQLMEILEAKADGQTPVSMQDML 184

  Fly   203 SRLVFESLGLVAFDRQMG-LIRKNRDNSDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKM 266
            :....:.|...||..:.. |:...:..|.|:.:........|.|        :.|.:  |..||.
  Rat   185 TCATIDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASRNT--------LAKFM--PGKRKQ 239

  Fly   267 KRTLNDSLNVSQKMLKENQDALEKRRQA---GEKINSNSMLERLMEI-----DPKVAVIMSLDIL 323
            .|.:.:|:.:.:::   .:|.:::||:|   ||.:.:: :|.::::.     |.:|.:...:...
  Rat   240 LREIRESIRLLRQV---GKDWVQRRREALKRGEDVPAD-ILTQILKAEEGAQDDEVLLDNFVTFF 300

  Fly   324 FAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKETLRYY 388
            .||.:.:|..|:..::.||:.|:..|:|:.|:..::.:|.. |:.|::..:.||..|:||:||.|
  Rat   301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRH-LDYEDLGRLQYLSQVLKESLRLY 364

  Fly   389 PNGFGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVS 453
            |..:||.|..:.:.::.|.|||..|.:|..:.|:.:..||:..|..|.|:|:      |......
  Rat   365 PPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF------GPGAPKP 423

  Fly   454 PFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEF 492
            .||:.||..|.|.|||::...:|::..:|||::  .:||
  Rat   424 RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ--RLEF 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-d	NP_995812.1	p450	70..508	CDD:299894	109/437 (25%)
Cyp46a1	XP_006240610.1	p450	34..466	CDD:278495	115/470 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010