DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12d1-d and npp-24

DIOPT Version :9

Sequence 1:	NP_995812.1	Gene:	Cyp12d1-d / 2768720	FlyBaseID:	FBgn0053503	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001379685.1	Gene:	npp-24 / 3564830	WormBaseID:	WBGene00022672	Length:	655	Species:	Caenorhabditis elegans

Alignment Length:	365	Identity:	79/365 - (21%)
Similarity:	132/365 - (36%)	Gaps:	103/365 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 LDSIVYFREHVRPDVYGEVQGLVASQ---NEAWGKLRSAINPIFMQPRGLRM-YYE-----PLSN 174
            |..:|.|     |:.:||.:.||..|   ..:.|..|...|.|    |.|:: .||     .|.:
Worm   276 LSHLVVF-----PNEFGEFRFLVKDQLRLPSSNGDPRIVQNQI----RSLKVSRYEIATSSSLFS 331

  Fly   175 IN-NEFIERIKEIRDPKTLE------------VPEDFTDEISRLV----FESLGLVAFDRQMGLI 222
            :| ..:.|.:..|....|||            :|   :||:|...    ..:|..|:......|.
Worm   332 VNIFPWFEALTSISPTSTLEKETRVSELVDAVIP---SDELSNTTKWTGARALRAVSVQLTQSLA 393

  Fly   223 RKNRDNSDALTLFQTSRDIFRLTF--KLDIQPSMWKIISTPTYRKMKRTLNDSL----NVSQKML 281
            .:..:      |...|.:|..|..  ..|.||:  .:.:..|:..:..|.|.:.    :|||..:
Worm   394 TEEEE------LLPESENIMHLVILENKDGQPA--HLFNISTFDNIWSTENKTSFGRDSVSQPPM 450

  Fly   282 KENQDALEKRRQAGEKINSNSMLERLMEIDPKVAVIMSLDI-LFAGVDATATLLSAVLLCLSKHP 345
            |                ::.|:.::|..:.|..|.::|..: ....:||......||...|.||.
Worm   451 K----------------STGSLEQQLAALKPLAACVISEKVSCEEAIDAAMKFFDAVDERLKKHC 499

  Fly   346 DKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKET-----LRYYPNGFGTMRTCQNDVILS 405
            :......|..|::..:..:|..::...|    :.:|:||     |:        :|..:....:.
Worm   500 EISKLFVERCLAVSSSAQALDEKQQSVD----QRLIEETNTVEELK--------IRMHETKERME 552

  Fly   406 GYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPE 445
            |.|  ||..||            :.|.||.:|   |.|.|
Worm   553 GAR--KGINVL------------FHRVDENVP---LSDNE 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-d	NP_995812.1	p450	70..508	CDD:299894	79/365 (22%)
npp-24	NP_001379685.1	Nup88	26..>212	CDD:401976
npp-24	NP_001379685.1	Smc	<455..>653	CDD:224117	34/150 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900