Protein Alignment Cyp12d1-d and Cyp24a1

DIOPT Version :10

• Sequence 1: NP_995812.1
• Gene: Cyp12d1-d / 2768720
• FlyBaseID: FBgn0053503
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_963966.1
• Gene: Cyp24a1 / 25279
• RGDID: 2462
• Length: 514
• Species: Rattus norvegicus
• Alignment Length: 509
• Identity: 133/509 - (26%)
• Similarity: 251/509 - (49%)
• Gaps: 34/509 - (6%)

  Fly    17 VRSSRSASVLAHEQAKSSITEEHKTYD--EIPRPNKF----KFMRAFMPGG-EFQNASITEYTSA 74
            |.|..|||....|.....:..:.:|.:  .:|.|..:    ..:..|..|| :.|:.::.||
  Rat    28 VTSKASASRAPKEVPLCPLMTDGETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEY--- 89

  Fly    75 MRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQG 139
             .|:||.|:.|  ..|..|.|...:...:|.::|.|...|:|..:.....:|:| |.:.|    |
  Rat    90 -HKKYGQIFRM--KLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDH-RNEAY----G 146

  Fly   140 LVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEIRDPKTLEVPEDFTDEISR 204
            |:..:.:.|.::|||.....|:|..:....:.::.:..:|:||:.|:.|.:. .:| |...|:::
  Rat   147 LMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERG-RIP-DLYSELNK 209

  Fly   205 LVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTFKLDIQP-SMWKIISTPTYRKMKR 268
            ..|||:.||.::::.||::|..: .:|||.....:.:.....|:.:.| .:.|.::|..::  ..
  Rat   210 WSFESICLVLYEKRFGLLQKETE-EEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQ--AH 271

  Fly   269 TLN-DSLNVSQKMLKENQDALEKRRQAGEKINSNSMLERLMEIDPKVAVIMSLDILFAGVDATAT 332
            ||. |::..|.|...:|:.....::...:.:......:.|.:.:...||   .::..|.|:.||.
  Rat   272 TLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAV---TELQLAAVETTAN 333

  Fly   333 LLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKETLRYYPNGFGTMRT 397
            .|..:|..||::|..|.:|.:|:.|::|...: ...|::::||||:|.:||::|..|:...|.||
  Rat   334 SLMWILYNLSRNPQAQRRLLQEVQSVLPDNQT-PRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397

  Fly   398 CQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGF 462
            .....:|..|.:||||.:.|.:.||......:....:|.|||||:     |:.:::||..||||.
  Rat   398 LDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQ-----KEKKINPFAHLPFGI 457

  Fly   463 GPRMCIGKRVVDLEMETTVAKLIRNFHVEFNRDASRPFKTMFLMEPAITFPFKF 516
            |.|||||:|:.:|::...:..:|:.:.:....:.......:.::.|:...|..|
  Rat   458 GKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAF 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-d	NP_995812.1	CYP24A1-like	76..515	CDD:410677	117/440 (27%)
Cyp24a1	NP_963966.1	CYP24A1	90..508	CDD:410738	116/438 (26%)