DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp12d1-d and CYP27A1

DIOPT Version :9

Sequence 1:NP_995812.1 Gene:Cyp12d1-d / 2768720 FlyBaseID:FBgn0053503 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_000775.1 Gene:CYP27A1 / 1593 HGNCID:2605 Length:531 Species:Homo sapiens


Alignment Length:467 Identity:115/467 - (24%)
Similarity:230/467 - (49%) Gaps:20/467 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 AKSSITEEHKTYDEIPRPNKFK-FMRAFMPGGEFQNASITEYTSAMRKRYGDIYVMPGMFGRKDW 94
            |...:....::.:||||..:.: |.:.|:.|...|   :.:.....:.:||.:::  ...|.:..
Human    46 AGPGVRRRQRSLEEIPRLGQLRFFFQLFVQGYALQ---LHQLQVLYKAKYGPMWM--SYLGPQMH 105

  Fly    95 VTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIF 159
            |...:...:|.|.|.||.:|.|:.::   .::||  .|.:....|...::...|.:||.|:|...
Human   106 VNLASAPLLEQVMRQEGKYPVRNDME---LWKEH--RDQHDLTYGPFTTEGHHWYQLRQALNQRL 165

  Fly   160 MQPRGLRMYYEPLSNINNEFIERIKEIR-DPKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIR 223
            ::|....:|.:..:.:.::|:.|:.::| :..:.....|..........|::..:.|::::|.::
Human   166 LKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQ 230

  Fly   224 KNRDNSDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKMKRTLNDSLNVSQKMLKENQDAL 288
            ::.. .|.:|..::...:|:.:......|. |.....|.:::.....|...:..:|::.|..:.:
Human   231 RSIP-EDTVTFVRSIGLMFQNSLYATFLPK-WTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDM 293

  Fly   289 EKRRQAG--EKINSNSMLERLM---EIDPKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQ 348
            |.:.||.  :.|..:..|..|:   ::.|:.|:....::|.||||.|:..|:..|..|||.|:.|
Human   294 EAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQ 358

  Fly   349 AKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKETLRYYPNGFGTMRTCQNDVILSGYRVPKGT 413
            ..|.||::.::|. ..:...::...||.|:||:|||||.||......|..:.::.:.|:..||.|
Human   359 EALHEEVVGVVPA-GQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNT 422

  Fly   414 TVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEME 478
            ..:....|:.::.|.:..|:.|.|.||||:.:........||..:|||:|.|.|:|:|:.:|||:
Human   423 QFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQ 487

  Fly   479 TTVAKLIRNFHV 490
            ..:|:||:.:.|
Human   488 LLLARLIQKYKV 499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp12d1-dNP_995812.1 p450 70..508 CDD:299894 106/427 (25%)
CYP27A1NP_000775.1 p450 61..526 CDD:306555 112/452 (25%)
Sterol-binding. /evidence=ECO:0000255 384..398 9/13 (69%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 194 1.000 Domainoid score I3171
eggNOG 1 0.900 - - E2759_KOG0159
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 201 1.000 Inparanoid score I3768
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48087
OrthoDB 1 1.010 - - D185685at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8467
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X156
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.880

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