DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp12d1-d and CYP24A1

DIOPT Version :9

Sequence 1:NP_995812.1 Gene:Cyp12d1-d / 2768720 FlyBaseID:FBgn0053503 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_000773.2 Gene:CYP24A1 / 1591 HGNCID:2602 Length:514 Species:Homo sapiens


Alignment Length:509 Identity:137/509 - (26%)
Similarity:259/509 - (50%) Gaps:48/509 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LSSARSVAIYVGPVRSSRSASVLAHEQAKSS----------ITEEHKTYD--EIPRPNKFKFMRA 56
            :|.:||:|.::..:||.|....|....|.:|          :|...:|.:  .:|.|..:..:.:
Human     5 ISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGS 69

  Fly    57 FM----PGG-EFQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRR 116
            .:    .|| :.|:.::.||    .|:||.|:.|  ..|..:.|...:...:|.::|.|..:|:|
Human    70 LLQILWKGGLKKQHDTLVEY----HKKYGKIFRM--KLGSFESVHLGSPCLLEALYRTESAYPQR 128

  Fly   117 DGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIE 181
            ..:.....:|:: |.:.|    ||:..:.|.|.::|||.....|:|..:......::.:..:|:.
Human   129 LEIKPWKAYRDY-RKEGY----GLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMG 188

  Fly   182 RIKEIRDPKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTF 246
            ||.|:.|.:  ...||...|:::..|||:.||.::::.||::||. ..:|:......:.:.....
Human   189 RIDELCDER--GHVEDLYSELNKWSFESICLVLYEKRFGLLQKNA-GDEAVNFIMAIKTMMSTFG 250

  Fly   247 KLDIQP-SMWKIISTPTYRKMKRTLN-DSLNVSQKMLKENQDALEKRRQ--AGEKINSNSMLERL 307
            ::.:.| .:.|.::|..::  ..||. |::..|.|...:|:  |||..|  :.:.:.......||
Human   251 RMMVTPVELHKSLNTKVWQ--DHTLAWDTIFKSVKACIDNR--LEKYSQQPSADFLCDIYHQNRL 311

  Fly   308 MEIDPKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMK 372
            .:.:...||   .::..|.|:.||..|..:|..||::|..|.||.:|:.|::| ::.:...|:::
Human   312 SKKELYAAV---TELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLP-ENQVPRAEDLR 372

  Fly   373 DMPYLRAVIKETLRYYPNGFGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLP 437
            :||||:|.:||::|..|:...|.||.....:|..|.:||||.::|.:.||......:....:|.|
Human   373 NMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRP 437

  Fly   438 ERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVE 491
            ||||::.|     :::||..||||.|.|||||:|:.:|::...:..::|.:.::
Human   438 ERWLQEKE-----KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQ 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp12d1-dNP_995812.1 p450 70..508 CDD:299894 120/426 (28%)
CYP24A1NP_000773.2 p450 59..512 CDD:278495 125/455 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 194 1.000 Domainoid score I3171
eggNOG 1 0.900 - - E2759_KOG0159
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 201 1.000 Inparanoid score I3768
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D185685at33208
OrthoFinder 1 1.000 - - FOG0000720
OrthoInspector 1 1.000 - - mtm8467
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X156
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.870

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