DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12d1-d and CYP46A1

DIOPT Version :9

Sequence 1:	NP_995812.1	Gene:	Cyp12d1-d / 2768720	FlyBaseID:	FBgn0053503	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_006659.1	Gene:	CYP46A1 / 10858	HGNCID:	2641	Length:	500	Species:	Homo sapiens

Alignment Length:	493	Identity:	124/493 - (25%)
Similarity:	222/493 - (45%)	Gaps:	64/493 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SASVLAHEQAKSSITEEHKTYDEIPRPNKFKFMRAFMP--------GGEFQNASITEYTSAMRKR 78
            ||.:||.....:.:......|:.||.|.:..|:...:|        ||........::.    |:
Human    10 SAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWA----KK 70

  Fly    79 YGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGE---VQGL 140
            ||.: |...:|.:...:.|    ..|.|  .:.:...:...||.:|   .....|:||   .|||
Human    71 YGPV-VRVNVFHKTSVIVT----SPESV--KKFLMSTKYNKDSKMY---RALQTVFGERLFGQGL 125

  Fly   141 VASQN-EAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEIRDPKT-LEVPEDFTDEIS 203
            |:..| |.|.|.|..|:..|.     |.....|....||..|::.||.:.|. .:.|....|.::
Human   126 VSECNYERWHKQRRVIDLAFS-----RSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLT 185

  Fly   204 RLVFESLGLVAFDRQMG-LIRKNRDNSDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKMK 267
            ....:.|...||..:.. |:...:..|.|:.|........|.|        :.|.:  |..||..
Human   186 YTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNT--------LAKFL--PGKRKQL 240

  Fly   268 RTLNDSLNVSQKMLKENQDALEKRRQA---GEKINSNSMLERLMEI-----DPKVAVIMSLDILF 324
            |.:.:|:...:::   .:|.:::||:|   ||::.:: :|.::::.     |.:..:...:....
Human   241 REVRESIRFLRQV---GRDWVQRRREALKRGEEVPAD-ILTQILKAEEGAQDDEGLLDNFVTFFI 301

  Fly   325 AGVDATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKETLRYYP 389
            ||.:.:|..|:..::.||:.|:..|:|:.|:..::.:| ..|:.|::..:.||..|:||:||.||
Human   302 AGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSK-RYLDFEDLGRLQYLSQVLKESLRLYP 365

  Fly   390 NGFGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSP 454
            ..:||.|..:.:.::.|.|||..|.:|..:.|:.:..||:..|..|.|:|:      |.......
Human   366 PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF------GPGAPKPR 424

  Fly   455 FTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEF 492
            ||:.||..|.|.|||::...:|::..:|||::  .:||
Human   425 FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ--RLEF 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-d	NP_995812.1	p450	70..508	CDD:299894	112/437 (26%)
CYP46A1	NP_006659.1	p450	34..466	CDD:365848	118/469 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920