DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp12d1-d and Cyp27a1

DIOPT Version :9

Sequence 1:NP_995812.1 Gene:Cyp12d1-d / 2768720 FlyBaseID:FBgn0053503 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_077226.2 Gene:Cyp27a1 / 104086 MGIID:88594 Length:533 Species:Mus musculus


Alignment Length:526 Identity:135/526 - (25%)
Similarity:239/526 - (45%) Gaps:73/526 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 TLSSARSVAIYVGPVRSSRSASVLAHEQAKSSITEEHKTYD---------EIPRPNKFKFM-RAF 57
            ||...|.|...:.|..:...|::.|..||:.| ||...|..         |:|.....:|: :.|
Mouse    12 TLLDPRVVGRGLCPQGARAKATIPAALQAQES-TEGPGTGQDRPRLRSPAELPGTGTLQFLFQLF 75

  Fly    58 MPGGEFQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKD---------IEMVFRNEGIW 113
            :.|....   :.:.....:.:||.:           |.|:|.|..         :|.|.|.||.:
Mouse    76 LQGYVLH---LPDLQVLNKTKYGPM-----------WTTSFGTYTNVNLASAPLLEQVMRQEGKY 126

  Fly   114 PRRDGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNE 178
            |.||.:|.....|:|     .|...|:..:|.|.|..||.|:....::|....:|.:.|:.:.::
Mouse   127 PIRDHMDQWKDHRDH-----KGLTYGIFIAQGEQWYHLRQALKQRLLKPDEAALYTDALNEVISD 186

  Fly   179 FIERIKEIRDPKTL--EVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDI 241
            ||.|:.::|.....  :|| |....:..|..|::..:.|::::|.::.:.. .|.....::...:
Mouse   187 FITRLDQVRAESESGDQVP-DMAHLLYHLALEAITYILFEKRIGCLKPSIP-EDTAAFIRSVAIM 249

  Fly   242 FRLTFKLDIQPSMWKIISTPTYRKMKRTLNDSLNV---SQKMLKENQDALEKRRQA----GEKIN 299
            |:.:..:...|. |   :.|.....||.||...|:   .:|::.|....|:.:.|.    |.:::
Mouse   250 FQNSVYITFLPK-W---TRPLLPFWKRYLNGWDNIFSFGKKLIDEKVQELKAQLQETGPDGVRVS 310

  Fly   300 -------SNSMLERLMEID--PKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREEL 355
                   :|.:|.....|.  |        ::|.||||.|:..|:..|..|||.|:.|..|.:|:
Mouse   311 GYLHFLLTNELLSTQETIGTFP--------ELLLAGVDTTSNTLTWALYHLSKSPEIQEALHKEV 367

  Fly   356 LSIMPTKDSLLNEENMKDMPYLRAVIKETLRYYPNGFGTMR-TCQNDVILSGYRVPKGTTVLLGS 419
            ..::|. ..:...::...||.|:||||||||.||......| ..:.:..::|:..||.|..:|..
Mouse   368 TGVVPF-GKVPQHKDFAHMPLLKAVIKETLRLYPVVPTNSRIITEKETEINGFLFPKNTQFVLCH 431

  Fly   420 NVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKL 484
            .|:.::.:.:|.|:.|.|.||||..|......:.||..:|||:|.|.|:|:|:.:|||:..:::|
Mouse   432 YVVSRDPSVFPEPNSFQPHRWLRKKEADNPGILHPFGSVPFGYGVRSCLGRRIAELEMQLMLSRL 496

  Fly   485 IRNFHV 490
            ::.:.:
Mouse   497 VQKYEI 502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp12d1-dNP_995812.1 p450 70..508 CDD:299894 117/449 (26%)
Cyp27a1NP_077226.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 34..60 7/26 (27%)
p450 82..527 CDD:278495 117/455 (26%)
Sterol-binding. /evidence=ECO:0000255 386..400 10/13 (77%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 190 1.000 Domainoid score I3255
eggNOG 1 0.900 - - E2759_KOG0159
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 196 1.000 Inparanoid score I3800
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48087
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8705
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X156
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.870

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