Protein Alignment Cyp12d1-d and cyp24a1

DIOPT Version :10

• Sequence 1: NP_995812.1
• Gene: Cyp12d1-d / 2768720
• FlyBaseID: FBgn0053503
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_012808417.2
• Gene: cyp24a1 / 100497429
• XenbaseID: XB-GENE-479201
• Length: 508
• Species: Xenopus tropicalis
• Alignment Length: 552
• Identity: 149/552 - (26%)
• Similarity: 254/552 - (46%)
• Gaps: 103/552 - (18%)

  Fly    13 YVGPVRSSRSASV---LAHEQAKSSITEEHKTYDEIPRPNKFKFMRAFMPG-------GEF---- 63
            ::|.:..|||.||   :....|...:.||     |:|.|:......|.:||       |..
 Frog     9 FLGMLLKSRSISVQHSIPTATAVCDLKEE-----ELPAPSSCPHSLAALPGPTKLPILGSLLDIL 68

  Fly    64 -------QNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDS 121
                   |:.::..|    .|::|.|:.|  ..|..|.|.......:|.::|.|..:|:|..:..
 Frog    69 RKGGLKRQHEALASY----HKQFGKIFRM--KLGSFDSVHIGAPCLLEALYREESNYPKRLEIKP 127

  Fly   122 IVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEI 186
            ...:|:: |.:.|    ||:..:.:.|.::|||.....|:|..:......::.:..:|::||..:
 Frog   128 WKAYRDY-RDEAY----GLLILEGKDWQRVRSAFQQKLMKPTEVGKLDTKINEVLVDFMKRIDSV 187

  Fly   187 RDPK-TLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTFKLDI 250
            .|.. |:   ||...|:::...||:.||.::::.|.::.|.  .:....|.|:..:...||.|
 Frog   188 CDEDGTI---EDLYCELNKWSLESICLVLYEKRFGFLQPNL--GEEAQNFITAIKMMMSTFGL-- 245

  Fly   251 QPSMWKIISTPTYRKMKRTLNDSLNVSQKMLKENQDALEK----------RRQAGEKINSNSMLE 305
                  ::.||.      .|:.|||.  |:.|::..|.:.          ||..  |::|....:
 Frog   246 ------MMVTPV------ELHKSLNT--KIWKDHTHAWDSIFKTAKCHIDRRLT--KLSSKGSED 294

  Fly   306 RLMEI--DPKV------AVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIM--- 359
            .|..|  |.|:      |.|  .::|...|:.||..|...:..:|::|..|.||.||:.|::
 Frog   295 FLCTIYNDSKLSKKEMYATI--TEMLIGAVETTANSLLWAIFNISRNPHIQKKLLEEIESVLLPD 357

  Fly   360 --PTKDSLLNEENMKDMPYLRAVIKETLRYYPNGFGTMRTCQNDVILSGYRVPKGTTVLLGSNVL 422
              ||.|.:.|      ||||:|.:||::|..|:...|.||...:.:|..|.:||||.:.:.|:||
 Frog   358 QVPTADDIRN------MPYLKACLKESMRITPSIPFTTRTLDKETVLGDYVLPKGTVLTINSHVL 416

  Fly   423 MKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRN 487
            ......:...::|.|||||:...|     ::||..:|||.|.|||||:|:.:|:::.|:..|||.
 Frog   417 GSNQECFDNWNQFRPERWLQQKNT-----INPFAHVPFGIGKRMCIGRRLAELQLQLTLCWLIRK 476

  Fly   488 FH-VEFNRDASRPFKTMFL--MEPAITFPFKF 516
            :. |..:.|   |.:|:.|  :.|:...|..|
 Frog   477 YEIVATDND---PVETLHLGTLMPSRELPVAF 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-d	NP_995812.1	CYP24A1-like	76..515	CDD:410677	130/465 (28%)
cyp24a1	XP_012808417.2	CYP24A1	84..502	CDD:410738	129/463 (28%)