DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12d1-d and cyp24a1

DIOPT Version :9

Sequence 1:	NP_995812.1	Gene:	Cyp12d1-d / 2768720	FlyBaseID:	FBgn0053503	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001082927.1	Gene:	cyp24a1 / 100004700	ZFINID:	ZDB-GENE-060825-1	Length:	505	Species:	Danio rerio

Alignment Length:	480	Identity:	118/480 - (24%)
Similarity:	231/480 - (48%)	Gaps:	36/480 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 RSSRSASVLAHEQAKSSITEEHKTYDEIPRPNKF----KFMRAFMPGG-EFQNASITEYTSAMRK 77
            :.:.|..||..:.|..|....| :.|.||.|..:    ..:.....|| :.|:.::..:    .|
Zfish    26 KPTSSVCVLDSKDAAGSAPCAH-SLDSIPGPTNWPLFGSLIEVIRNGGLKRQHETLIHF----HK 85

  Fly    78 RYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVA 142
            ::|.|:.|  ..|..:.|...:...:|.::|.||.:|.|..:.....:|     |:..|..||:.
Zfish    86 KFGKIFRM--KLGSFESVHIGSPCLLEALYRKEGSYPERLEIKPWKAYR-----DMRDEAYGLLI 143

  Fly   143 SQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEIRDPKTLEVPEDFTDEISRLVF 207
            .:...|.::|||.....|:|..:......::.:..:.|:||.::....     :....|:::..|
Zfish   144 LEGRDWQRVRSAFQQKLMKPTEVMKLDGKINEVAADLIKRIGKVNGKM-----DALYFELNKWSF 203

  Fly   208 ESLGLVAFDRQMGLIRK--NRDNSDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKMKRTL 270
            |::..|.:|::.||::.  :::..|.:|..:|....|.......::  :.|.::|.|::......
Zfish   204 ETICYVIYDKRFGLLQDSVSKEGMDFITAVKTMMSTFGTMMVTPVE--LHKTLNTKTWKDHTEAW 266

  Fly   271 NDSLNVSQKMLKENQDALEKRRQAGEKINSNSMLERLMEIDPKVAVIMSLDILFAGVDATATLLS 335
            :...:.::..:.:|   |:|:.. ||..:..|.:.....:..|.....:.::...||:.||..:.
Zfish   267 DRIFSTAKHYIDKN---LQKQSN-GEADDFLSDIFHNGNLTKKELYAATTELQVGGVETTANSML 327

  Fly   336 AVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKETLRYYPNGFGTMRTCQN 400
            .|:..||::|..|.||.:|:..::|...: ...|::|.||||:|.:||::|..|:...|.||...
Zfish   328 WVIFNLSRNPCAQGKLLKEIQDVVPAGQT-PRAEHIKSMPYLKACLKESMRVSPSVPFTSRTLDK 391

  Fly   401 DVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPR 465
            |.:|..|.:||||.::|.|..:.....|:....:|.|||||.:     |..::||..:|||.|.|
Zfish   392 DTVLGDYTLPKGTVLMLNSQAIGVSEEYFDNGRQFRPERWLEE-----KSSINPFAHVPFGVGKR 451

  Fly   466 MCIGKRVVDLEMETTVAKLIRNFHV 490
            ||||:|:.:|:::..:..::|::.:
Zfish   452 MCIGRRLAELQIQLGLCWILRDYKI 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-d	NP_995812.1	p450	70..508	CDD:299894	105/423 (25%)
cyp24a1	NP_001082927.1	p450	53..493	CDD:278495	110/452 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920